2Sum (500mg) 1 Vial Injection

Cefoperazone 500mg and Sulbactam 500mg injection is a combination antibiotic used to treat a wide range of bacterial infections. Cefoperazone is a broad-spectrum cephalosporin antibiotic that works by inhibiting the synthesis of bacterial cell walls, leading to the destruction of bacteria. Sulbactam is a beta-lactamase inhibitor that enhances the effectiveness of Cefoperazone by preventing the breakdown of the antibiotic by certain bacteria that produce beta-lactamase enzymes. This combination is commonly used to treat infections such as respiratory tract infections, urinary tract infections, abdominal infections, skin and soft tissue infections, and infections associated with surgery or trauma. The injection is typically administered in a hospital or clinical setting under the supervision of a healthcare provider, with the dosage and frequency determined based on the severity of the infection and the patient's condition.

Cefoperazone 500mg, Sulbactam 500mg

antibiotic

injection

Following are the uses of Cefoperazone 500mg, Sulbactam 500mg injection:

• Used to treat a variety of bacterial infections, including respiratory tract infections such as pneumonia and bronchitis.
• Effective in treating urinary tract infections (UTIs) caused by susceptible bacteria.
• Helps manage intra-abdominal infections, including peritonitis and abscesses.
• Prescribed for skin and soft tissue infections, including cellulitis and wound infections.
• Used in the treatment of bone and joint infections.
• Can be used for gynecological infections, including pelvic inflammatory disease (PID) and endometritis.
• Effective in treating bloodstream infections (bacteremia) and sepsis caused by susceptible organisms.
• Often used in post-surgical infections or infections in immunocompromised patients.

Following is the dosage information for Cefoperazone 500mg, Sulbactam 500mg injection:

• The typical dose for adults is 1 to 2 grams of Cefoperazone combined with 0.5 to 1 gram of Sulbactam, administered every 12 hours, depending on the severity of the infection.
• In more severe infections, the dose may be increased up to 4 grams of Cefoperazone combined with 2 grams of Sulbactam per day, administered in divided doses.
• For pediatric patients, the dosage is usually based on body weight, typically 50 to 100 mg/kg/day, divided into two doses.

In case of an overdose of Cefoperazone 500mg, Sulbactam 500mg injection, it is essential to seek immediate medical attention. Symptoms of overdose may include severe gastrointestinal distress, such as nausea, vomiting, and diarrhea, as well as potential kidney or liver damage. Treatment for overdose typically involves supportive care to manage symptoms and prevent further complications. Hemodialysis may be considered in severe cases to help remove the drug from the system, especially in individuals with renal impairment. It's important to inform healthcare providers about the overdose as soon as possible, so they can provide the appropriate interventions. If you suspect an overdose, contact your healthcare provider or go to the nearest emergency department immediately.

If you miss a dose of Cefoperazone 500mg, Sulbactam 500mg injection, it is important to take it as soon as you remember, provided it is not too close to the time for your next scheduled dose. If the next dose is near, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose, as this can increase the risk of side effects. If you are unsure about what to do, or if you miss multiple doses, consult your healthcare provider for further guidance. It is essential to complete the full course of treatment as prescribed to effectively treat the infection.

To use Cefoperazone 500mg, Sulbactam 500mg Injection typically, it should be administered intravenously or intramuscularly, depending on your healthcare provider's instructions. The injection should be given by a trained healthcare professional in a medical setting.

Following are the situations when Cefoperazone 500mg, Sulbactam 500mg injection should not be used:

• Should not be used in individuals with a known allergy to cefoperazone, sulbactam, or other beta-lactam antibiotics.
• Not recommended for patients with a history of severe hypersensitivity reactions, including anaphylaxis, to cephalosporins or penicillins.
• Should not be used in patients with a history of bleeding disorders, as it can interfere with blood clotting.
• Avoid in individuals with severe renal or hepatic impairment unless the healthcare provider determines the benefits outweigh the risks.
• Should not be used during pregnancy unless the potential benefits justify the risks to the fetus.
• Not recommended for breastfeeding mothers unless deemed necessary by a healthcare provider, as the drug may pass into breast milk.
• Contraindicated in patients with gastrointestinal conditions such as colitis or a history of gastrointestinal bleeding.

Following are side effects of Cefoperazone 500mg, Sulbactam 500mg injection:

• Rash
• Diarrhea
• Nausea
• Vomiting
• Headache
• Dizziness
• Allergies
• Fever
• Pain
• Bleeding

Following are the precautions and warnings for Cefoperazone 500mg, Sulbactam 500mg injection:

• Use with caution in patients with a history of hypersensitivity or allergic reactions to cephalosporins, penicillins, or other beta-lactam antibiotics, as cross-reactivity may occur.
• Caution is advised in patients with renal or hepatic impairment, as dosage adjustments may be necessary to avoid toxicity.
• Monitor liver function and renal function regularly during treatment, especially in prolonged therapy or in patients with pre-existing conditions.
• Cefoperazone can cause bleeding disorders, so it should be used with caution in patients receiving anticoagulants or those with bleeding disorders.
• Prolonged use may lead to superinfections, including fungal infections or infections caused by resistant organisms.
• This medication should be used with caution in pregnant women, particularly during the first trimester, and should only be used if the potential benefit justifies the potential risk to the fetus.
• Cefoperazone is excreted in breast milk, so it should be used cautiously in breastfeeding women.
• It may cause adverse effects on the gastrointestinal system, including diarrhea, nausea, and vomiting. If severe diarrhea occurs, especially with blood or mucus, discontinue use and seek medical attention immediately.
• It should be used cautiously in patients with gastrointestinal disorders, such as colitis, as it may exacerbate these conditions.

Following are the drug interactions for Cefoperazone 500mg, Sulbactam 500mg injection:

• Cefoperazone may enhance the anticoagulant effect of warfarin and other blood thinners, increasing the risk of bleeding. Regular monitoring of INR (international normalized ratio) is advised.
• Concurrent use of Cefoperazone with aminoglycoside antibiotics (e.g., gentamicin) may increase the risk of nephrotoxicity and ototoxicity.
• This medication can increase the blood levels of Cefoperazone by inhibiting its renal excretion, which may lead to higher risk of side effects when used with probenecid.
• The combination of Cefoperazone with diuretics like furosemide may increase the risk of kidney damage, especially in patients with renal impairment.
• Using Cefoperazone together with other beta-lactam antibiotics can potentially lead to an increased risk of adverse effects, particularly allergic reactions or gastrointestinal issues.
• Cefoperazone may alter blood sugar levels, so close monitoring of blood glucose is recommended when used with antidiabetic drugs like metformin.
• Cefoperazone may increase the plasma levels of cyclosporine, potentially raising the risk of cyclosporine-related toxicity.
• Although not common, there may be a slight reduction in the effectiveness of oral contraceptives when used with Cefoperazone. It’s advisable to use additional contraception during treatment.
• Cefoperazone may reduce the effectiveness of live vaccines (e.g., yellow fever vaccine), so vaccination status should be checked before starting treatment.

Following are the food interactions for Cefoperazone 500mg, Sulbactam 500mg injection:

• No significant food interactions have been identified with Cefoperazone and Sulbactam injection.
• It can be taken with or without food, but it is recommended to follow your healthcare provider's instructions regarding meal timing.
• Taking the injection with a high-fat meal may delay the absorption of certain antibiotics, but this is generally not a major concern with Cefoperazone and Sulbactam.
• Alcohol consumption should be avoided during treatment, as it may increase the risk of side effects, such as gastrointestinal upset or liver toxicity.

Cefoperazone 500mg, Sulbactam 500mg injection should be stored at room temperature, away from direct sunlight and moisture to maintain its potency. Keep the injection vials tightly closed when not in use. It should be stored in a cool, dry place and out of the reach of children. Do not freeze the medication. If the medication has expired or is no longer needed, dispose of it according to local disposal guidelines. Avoid flushing it down the toilet or pouring it down the drain unless specifically instructed, as improper disposal may harm the environment. If unsure about how to dispose of the medication, consult a pharmacist for safe disposal instructions.

Following are some quick tips for Cefoperazone 500mg, Sulbactam 500mg injection:

• Take the injection exactly as prescribed by your healthcare provider to ensure effective treatment.
• Ensure that the full course of antibiotics is completed, even if symptoms improve, to avoid antibiotic resistance.
• Inform your healthcare provider of any allergies, especially to cephalosporins or penicillins, before starting the treatment.
• Monitor for any signs of allergic reactions such as rash, swelling, or difficulty breathing, and seek immediate medical help if these occur.
• Avoid alcohol during treatment, as it may increase the risk of side effects such as gastrointestinal discomfort.
• Report any unusual side effects, such as bleeding or bruising, to your doctor immediately.
• Store the injection properly in a cool, dry place away from light, and ensure it is kept out of reach of children.
• If you miss a dose, consult your healthcare provider about what steps to take next.
• Do not share your medication with others, even if they have similar symptoms, to avoid misuse.