Aclovir (400mg) 35 Tablets

Acyclovir 400mg Tablet primarily acts by selectively inhibiting the replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV). It achieves this by targeting and inhibiting the viral DNA polymerase, an enzyme crucial for viral DNA synthesis. Acyclovir is a synthetic nucleoside analogue that resembles guanine, and once inside the infected cells, it is converted into its active form, acyclovir triphosphate. This active form competitively inhibits viral DNA polymerase, leading to the incorporation of acyclovir into the growing viral DNA chain, which results in chain termination and prevents further viral DNA synthesis, effectively halting the replication of the herpes virus.

Acyclovir 400mg

Antiviral (Acyclovir)

Tablet

The following are the uses of Acyclovir 400mg Tablet:

• Used for treating herpes simplex virus infections, including cold sores and genital herpes.
• Used to alleviate symptoms and speed up healing in cases of herpes outbreaks.
• Used for managing chickenpox, reducing severity and discomfort.
• Used as a suppressive therapy to reduce the frequency and severity of recurrent herpes infections.
• Used to prevent the spread of herpes infections to other parts of the body.
• Used for treating herpes infections in immunocompromised patients.
• Used post-transplant to manage herpes infections in transplant recipients.

The following dosage can be followed:

• For adults with genital herpes

• For shingles and chickenpox

• Dosage may vary for specific conditions; consult a healthcare professional.

In the case of an overdose of Acyclovir 400mg Tablets, individuals may experience a range of symptoms. These can include gastrointestinal issues such as nausea, vomiting, and diarrhea. Neurological symptoms like dizziness, confusion, and seizures may also occur. It is important to recognize that an overdose can lead to severe health complications, and seeking medical assistance promptly is advised. If you suspect an overdose, contact emergency services or a healthcare professional immediately for guidance and appropriate treatment.

In the case of a missed dose of Acyclovir 400mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is important to maintain a consistent medication routine for optimal results.

To take Acyclovir 400mg Tablets, swallow the tablet whole with a full glass of water, preferably with food, at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the situations when Acyclovir 400mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Acyclovir or similar antiviral medications.
• Not suitable for patients with kidney disease or impaired kidney function.
• Contraindicated in individuals with a history of severe allergic reactions to medications.
• Should not be used in patients with a weakened immune system due to conditions like HIV/AIDS.
• Not recommended for those with a history of neurological disorders or severe kidney problems.
• Avoid using if you have a history of liver disease or decreased liver function.
• Not suitable for individuals with a known sensitivity to the ingredients in the tablet formulation.

The side effects of Acyclovir 400mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Fatigue and drowsiness
• Skin rash or itching
• Dizziness
• Confusion
• Kidney problems (increased thirst, changes in urination)

Following are the precautions and warnings for Acyclovir 400mg Tablet:

• Do not take this medication if you are allergic to Acyclovir or similar medications.
• Patients with kidney or liver problems should use this medication with caution and under medical supervision as dosage adjustments may be necessary.
• Elderly patients may be more susceptible to side effects; regular monitoring is recommended.
• Avoid prolonged or excessive exposure to sunlight or UV rays while taking this medication, as it may increase sensitivity.
• Stay well-hydrated while taking Acyclovir to reduce the risk of kidney-related side effects.
• If you have a weakened immune system, you may experience prolonged or more severe side effects.
• This medication should be used with caution in patients with a history of neurological disorders, as it may cause neurological side effects.
• Acyclovir may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you.

Following are the drug interactions for Acyclovir 400mg Tablet:

• Probenecid, when used together with Acyclovir, can increase the risk of kidney problems by reducing the elimination of Acyclovir.
• Acyclovir may decrease the effectiveness of Myfortic (mycophenolate sodium) and other mycophenolate products, leading to potential organ rejection in transplant patients.
• The combination of Acyclovir with other drugs that affect the kidneys, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can increase the risk of kidney damage.
• Taking Acyclovir with other antiviral medications like Valganciclovir may increase the risk of hematologic toxicity and impair kidney function.
• Drugs that compete for renal tubular secretion, like Zidovudine, may increase Acyclovir plasma concentrations.
• Acyclovir may increase the blood levels of Theophylline, potentially leading to Theophylline toxicity.
• The immunosuppressive effects of Tacrolimus may be reduced when used with Acyclovir, requiring close monitoring.
• Concurrent use of Acyclovir and other nephrotoxic drugs may increase the risk of kidney injury.

Following are the food interactions for Acyclovir 400mg Tablet:

• Alcohol consumption should be avoided or limited as it may lead to increased drowsiness and dizziness.
• Ensure adequate hydration by drinking plenty of fluids, especially water, while taking this medication.
• Acyclovir may be taken with or without food, but maintaining a consistent routine is advisable.
• Avoid grapefruit and grapefruit juice as they can affect the absorption of the drug.
• Avoid caffeine-rich foods and beverages as they may increase the likelihood of side effects such as nervousness and tremors.
• Dairy products like milk and yogurt can be consumed but monitor for any potential stomach upset.
• Avoid high-fat meals as they may delay the absorption of Acyclovir.
• Always follow the advice of your healthcare provider regarding specific dietary restrictions or recommendations.

Acyclovir 400mg Tablets should be stored in a cool and dry place, preferably at room temperature (68°F to 77°F). Protect the tablets from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for advice on safe disposal methods. It is crucial to keep the medication away from children and pets to prevent accidental ingestion, as it can be harmful if consumed without medical supervision.

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Following are the quick tips for Acyclovir 400mg Tablet:

• Consult your doctor before starting this medication for personalized advice.
• Take the tablet as directed by your healthcare professional, typically 2-5 times daily.
• Consume the tablet with a full glass of water, swallowing it whole without crushing or chewing.
• Maintain a consistent dosing schedule by taking it at evenly spaced intervals.
• Complete the full prescribed course even if symptoms improve to ensure infection clearance.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Store the tablets at room temperature, away from moisture and light.