Alfa-D (0.5mcg) 10 Tablets

Alfacalcidol, the active ingredient in Alfacalcidol 0.5 mcg tablets, is a synthetic analog of vitamin D. Its mechanism of action involves mimicking the effects of naturally occurring vitamin D metabolites in the body. Alfacalcidol is rapidly converted in the liver to 1,25-dihydroxyvitamin D, which is the active form of vitamin D. This active metabolite binds to vitamin D receptors (VDR) present in various target tissues, primarily the intestine, kidneys, and bones. By activating the VDR, Alfacalcidol stimulates the absorption of calcium and phosphorus from the intestines, increases renal tubular reabsorption of calcium, and promotes bone mineralization. It enhances the efficiency of calcium absorption, leading to increased serum calcium levels. This process plays a crucial role in maintaining calcium homeostasis, promoting bone health, and supporting various physiological processes that require calcium and vitamin D.

Alfacalcidol 0.5mcg

Vitamin D analogue

Tablet

The following are the uses of Alfacalcidol 0.5mcg Tablet:

• Used for managing calcium deficiency in conditions like hypoparathyroidism, where the body produces too little parathyroid hormone.
• Used for treating conditions causing low blood calcium levels, such as renal osteodystrophy in chronic kidney disease.
• Used for preventing and treating bone weakness and pain in various bone-related disorders.
• Used for managing calcium and phosphate imbalances in patients undergoing dialysis.
• Used for maintaining calcium levels in conditions where calcium absorption from the intestine is impaired.
• Used for supporting bone health and preventing fractures in individuals with osteoporosis.
• Used for correcting vitamin D deficiency, ensuring proper calcium absorption and bone mineralization.

Take as per doctor's prescription

In the case of an overdose of Alfacalcidol 0.5mcg Tablets, it is important to recognize the signs and symptoms, which may include nausea, vomiting, muscle weakness, and increased thirst. Seek medical assistance promptly to ensure appropriate treatment and management. Overdose can lead to severe health complications, so it is crucial to act quickly and contact a healthcare professional for guidance and support. Timely intervention can help mitigate potential risks.

In the case of a missed dose of Alfacalcidol 0.5mcg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is crucial to maintain consistency in taking this medication as prescribed.

To take Alfacalcidol 0.5mcg Tablet, place the tablet under your tongue and allow it to dissolve completely, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Alfacalcidol 0.5mcg Tablet should not be taken:

• Should not be used in patients with a known hypersensitivity or allergy to Alfacalcidol or any vitamin D compounds.
• Contraindicated in patients with high blood calcium levels (hypercalcemia) or high blood calcium and phosphate levels (hypercalciuria).
• Not suitable for patients with uncontrolled high blood calcium levels due to rickets or osteomalacia.
• Should not be used in patients with impaired kidney function or those on dialysis, as it can lead to excessive calcium levels.
• Contraindicated during pregnancy, especially in the first trimester, due to potential harm to the fetus.
• Not recommended for breastfeeding mothers, as Alfacalcidol can pass into breast milk and may harm the nursing infant.
• Avoid in patients with a history of calcium-related kidney stones or those with conditions that increase the risk of developing kidney stones.

The side effects of Alfacalcidol 0.5mcg Tablet may include:

• Nausea and vomiting
• Headache
• Dizziness
• Constipation or diarrhea
• Loss of appetite
• Increased thirst and frequent urination
• Muscle or joint pain
• Elevated calcium levels in the blood (hypercalcemia)

Following are the precautions and warnings for Alfacalcidol 0.5mcg Tablet:

• Do not take this medication if you are allergic to alfacalcidol or any similar vitamin D derivatives.
• Regular monitoring of calcium levels in the blood and urine is essential during treatment.
• Patients with a history of kidney disease or impaired kidney function should exercise caution and consult a doctor, as dosage adjustments may be necessary.
• Alfacalcidol can cause an increase in calcium levels in the blood, which may lead to calcification in the kidneys and other organs. Regular monitoring is required.
• Avoid excessive use of calcium supplements or vitamin D-rich foods while on this medication.
• Elderly patients may be more susceptible to the effects of this medication; regular monitoring is recommended.
• This medication should be used with caution in pregnant and breastfeeding women under strict medical supervision.

Following are the drug interactions for Alfacalcidol 0.5mcg Tablet:

• Anticonvulsants like phenytoin and phenobarbital may decrease the effectiveness of Alfacalcidol.
• Thiazide diuretics can enhance the effects of Alfacalcidol, requiring dosage adjustments.
• Calcium-containing antacids can reduce the absorption of Alfacalcidol when taken together.
• Corticosteroids may increase calcium excretion, reducing Alfacalcidol's effectiveness.
• Digitalis glycosides may lead to cardiac arrhythmias when used with Alfacalcidol.
• Cisplatin may increase the risk of hypercalcemia when combined with Alfacalcidol.
• Antibiotics such as tetracyclines and quinolones can decrease the absorption of Alfacalcidol.

Following are the food interactions for Alfacalcidol 0.5mcg Tablet:

• Alfacalcidol absorption can be affected by high-fiber diets, as fiber can bind to the drug and reduce its absorption. Avoid excessive fiber intake shortly before or after taking the medication.
• Calcium-rich foods like milk, cheese, and yogurt can be beneficial when taking Alfacalcidol, as they help maintain calcium levels in the body. Consume these foods as part of a balanced diet.
• Avoid excessive consumption of foods rich in vitamin D, such as fatty fish, egg yolks, and fortified dairy products, as this medication is a vitamin D analog, and excessive vitamin D intake can lead to hypercalcemia.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Alfacalcidol, potentially increasing its blood levels and the risk of side effects.
• Alcohol can increase the risk of kidney damage and should be consumed in moderation or avoided while taking Alfacalcidol, especially if you have a history of kidney issues.
• Avoid excessive intake of oxalate-rich foods like spinach, rhubarb, and beet greens, as Alfacalcidol can increase calcium levels, and high calcium levels can lead to the formation of calcium oxalate kidney stones.
• Maintain a balanced diet with a variety of fruits, vegetables, and lean proteins to support overall health while taking this medication.
• Always follow the dietary recommendations provided by your healthcare professional to ensure optimal treatment outcomes.

Alfacalcidol 0.5mcg Tablets should be stored in a cool, dry area, ideally at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Do not expose the tablets to heat or cold environments as this can impact their effectiveness. Always adhere to the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Contact your pharmacist or healthcare provider for guidance on safe disposal methods, ensuring you do not flush or pour the medication down the drain, and keep it away from children to prevent accidental consumption.

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Following are the quick tips for Alfacalcidol 0.5mcg Tablet:

• Take the tablet as directed by your doctor, typically once daily or as prescribed.
• Consume the tablet on an empty stomach, preferably at least 30 minutes before a meal.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Maintain a consistent schedule for taking the medication for better effectiveness.
• Regularly monitor your calcium and phosphate levels as directed by your doctor.
• Inform your doctor about all medications and supplements you are taking.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.