Alzilo (0.5mg) 10 Tablets

Rasagiline 0.5mg Tablet acts as a selective and irreversible inhibitor of monoamine oxidase-B (MAO-B). It works by blocking the action of MAO-B, an enzyme responsible for breaking down certain neurotransmitters in the brain, primarily dopamine. By inhibiting MAO-B, rasagiline increases the levels of dopamine in the brain, which is believed to improve motor function and reduce the symptoms associated with Parkinson's disease. This mechanism of action helps in managing the symptoms of Parkinson's disease, particularly in improving motor control and reducing the motor fluctuations experienced by patients.

Monoamine Oxidase Inhibitor.

Tablet

The following are the uses of Rasagiline 0.5mg Tablet:

• Used for treating symptoms of Parkinson's disease, improving muscle control and reducing stiffness.
• Used to enhance dopamine levels in the brain, providing relief from motor symptoms.
• Used to manage motor fluctuations in patients with advanced Parkinson's.
• Used as a monotherapy or in combination with other medications for tailored treatment.
• Used to potentially delay the need for Levodopa therapy in early Parkinson's.
• Used to improve quality of life by reducing 'off' time and increasing 'on' time.
• Used for its once-daily dosing convenience and effectiveness in symptom control.

To be taken as per doctor's prescription

In the case of an overdose of Rasagiline 0.5mg Tablets, it is important to recognize the potential severity of the situation. Symptoms may include severe dizziness, fainting, and a significant drop in blood pressure. Promptly seek medical advice, and inform healthcare professionals of the amount ingested and any other medications taken. Quick action can help mitigate the risks associated with Rasagiline overdose and ensure appropriate medical care is provided.

In the case of a missed dose of Rasagiline 0.5mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your dosage and get back on track with your medication regimen. It is recommended to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Rasagiline 0.5mg Tablet, place the tablet in your mouth and swallow it whole with a glass of water, preferably at the same time each day, as directed by your healthcare professional.

Here are the conditions and situations when Rasagiline 0.5mg Tablet should not be taken:

• Rasagiline is contraindicated in individuals with a known hypersensitivity or severe reaction to rasagiline or any of its excipients.
• Not to be used in patients with severe liver impairment or liver disease.
• Do not take if you have a history of pheochromocytoma, a rare tumor of the adrenal gland.
• Avoid if you have a condition called 'narrow-angle glaucoma'.
• Rasagiline is not recommended for individuals with a history of orthostatic hypotension (a sudden drop in blood pressure upon standing).
• Should not be used in combination with certain medications like selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, or other monoamine oxidase inhibitors (MAOIs).
• Do not take this medication if you have a history of severe or frequent headaches.
• Not suitable for individuals with a history of certain psychiatric disorders or aggressive behavior.

The side effects of Rasagiline 0.5mg Tablet may include:

• Dizziness
• Headache
• Nausea
• Fatigue
• Insomnia
• Joint pain
• Flu-like symptoms
• Weight loss

Following are the precautions and warnings for Rasagiline 0.5mg Tablet:

• This medication is not suitable for individuals with a known hypersensitivity or allergy to Rasagiline or any of its excipients.
• Rasagiline is contraindicated in patients with severe liver impairment, and caution should be exercised in those with mild to moderate liver disease.
• Patients with a history of peptic ulcer disease or gastrointestinal bleeding should be closely monitored, as Rasagiline may increase the risk of these conditions.
• It is essential to inform your doctor if you are taking any other medications, especially antidepressants, as serious drug interactions can occur.
• Patients with a history of orthostatic hypotension should be cautious as this medication may exacerbate these symptoms.
• Rasagiline can cause dizziness and sleepiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Pregnant and breastfeeding women should consult their healthcare provider before taking Rasagiline, as its safety during these periods is not well-established.

Following are the drug interactions for Rasagiline 0.5mg Tablet:

• Concomitant use with other monoamine oxidase inhibitors (MAOIs) is contraindicated, as it can lead to severe hypertension and other serious reactions.
• Rasagiline may interact with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants, increasing the risk of serotonin syndrome.
• It can interact with opioid analgesics, leading to potential respiratory depression. Close monitoring is required.
• Antipsychotics and other central nervous system (CNS) depressants may have additive effects when used with Rasagiline, requiring careful dose adjustment.
• The effectiveness of Rasagiline may be reduced when used with dopamine agonists, requiring close observation.
• Caution is advised when using Rasagiline with drugs that affect liver metabolism, as it may alter the drug's elimination.
• Some antihypertensive medications may have an additive effect on blood pressure when combined with Rasagiline, requiring blood pressure monitoring.

Following are the food interactions for Rasagiline 0.5mg Tablet:

• Avoid high-tyramine foods like aged cheeses, cured meats, and fermented foods. These can interact with Rasagiline, causing high blood pressure.
• Foods containing tyramine, including certain beans, avocados, and pickled or smoked products, should be limited.
• Alcohol should be consumed in moderation or avoided as it may interfere with the medication's effectiveness and increase the risk of side effects.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of Rasagiline.
• Avoid energy drinks and beverages with high caffeine content as they may interact with the medication.
• Consuming a balanced diet with regular protein intake is recommended, ensuring a stable level of amino acids in the body.
• Some dietary supplements, especially those containing amino acids or herbal extracts, should be used with caution and under medical supervision.

Rasagiline 0.5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (below 25°C or 77°F). Protect the tablets from light and moisture by keeping them in their original container with the lid tightly sealed. It is crucial to maintain a consistent storage environment, avoiding exposure to excessive heat, cold, or humidity. Regularly check the expiration date on the packaging, and never use the medication beyond this date. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines or consult a pharmacist to ensure safe and environmentally friendly disposal. Keep the medication out of children's reach, as accidental ingestion can be harmful.

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Following are the quick tips for Rasagiline 0.5mg Tablet:

• Start with the recommended dosage and consult your doctor for personalized instructions.
• Take the tablet at the same time each day to maintain a consistent medication level.
• Swallow the tablet whole with a full glass of water for easy swallowing.
• You can take it with or without food, but be consistent with your choice.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.

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