AM-Telsan (10/80mg) 14 Tablets

Amlodipine 10mg and Telmisartan 80mg in combination work synergistically to lower blood pressure through distinct mechanisms of action. Amlodipine belongs to the calcium channel blocker class of drugs. It selectively inhibits calcium ion influx across cellular membranes, particularly in smooth muscle cells of the heart and blood vessels. By blocking calcium channels, amlodipine relaxes vascular smooth muscles, leading to vasodilation and reduced peripheral vascular resistance. This action decreases blood pressure by enhancing blood flow and reducing the workload on the heart. On the other hand, Telmisartan is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to its receptors, primarily the AT1 receptors, in various tissues, including vascular smooth muscle and the adrenal glands. Angiotensin II is a potent vasoconstrictor and aldosterone-stimulating hormone. By blocking its effects, telmisartan prevents vasoconstriction and reduces aldosterone secretion, resulting in decreased blood pressure and reduced fluid retention. Together, these mechanisms contribute to the antihypertensive effects of the Amlodipine 10mg and Telmisartan 80mg Tablet combination.

Amlodipine 10mg, Telmisartan 80mg

Calcium channel blocker, Angiotensin II receptor blocker.

Tablet

The following are the uses of Amlodipine 10mg, Telmisartan 80mg Tablet:

• Used for managing high blood pressure
• Used to treat angina (chest pain)
• Used to prevent and manage heart-related chest pain
• Used to improve exercise tolerance in patients with cardiovascular conditions
• Used to reduce the risk of heart attack and stroke in certain patients
• Used to treat hypertension and related complications
• Used to relax and widen blood vessels, improving blood flow
• Used to lower blood pressure and reduce strain on the heart

To be taken as per doctor's prescription

In the case of an overdose of Amlodipine 10mg and Telmisartan 80mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and an abnormal heart rate. It is important to seek medical advice promptly if an overdose is suspected. Symptoms can vary, but immediate action should be taken to prevent potential complications. Overdosing on these medications can lead to severe health risks, so contacting a healthcare professional or seeking emergency assistance is essential for proper management and treatment.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Telmisartan 80mg Tablet, if you miss a dose, take it as soon as you remember, but if it is closer to your next dose time, skip the missed dose and continue with your regular dosing regimen. It is important not to double the dose to make up for a missed one.

To take Amlodipine 10mg and Telmisartan 80mg tablets, swallow one tablet daily, preferably at the same time each day, with or without food, as directed by your healthcare provider.

Following are the conditions or situations when Amlodipine 10mg, Telmisartan 80mg Tablet should not be taken:

• Do not take if you are allergic to Amlodipine, Telmisartan, or any other similar medications.
• Avoid if you have a history of angioedema (swelling of the face, lips, tongue, or throat) with previous use of similar drugs.
• Should not be used if you have severe liver disease or biliary obstruction (blockage in the bile ducts).
• Contraindicated in individuals with severe hypotension (very low blood pressure).
• Do not use if you have aortic valve stenosis (narrowing of the aortic valve in the heart).
• Not suitable for patients with heart failure after a heart attack.
• Avoid if you have obstructive jaundice (a type of liver disease with yellowing of the skin and eyes).
• Should not be taken during pregnancy or while breastfeeding.

The side effects of Amlodipine 10mg, Telmisartan 80mg Tablet may include:

• Dizziness or lightheadedness
• Swelling of the ankles and feet (peripheral edema)
• Fatigue or drowsiness
• Headache
• Nausea and stomach pain
• Increased heart rate (tachycardia)
• Skin rash or itching
• Muscle cramps

Following are the precautions and warnings for Amlodipine 10mg, Telmisartan 80mg Tablet:

• This medication should be used with caution in patients with liver disease, as it may affect liver function. Regular monitoring is necessary.
• It is important to monitor blood pressure regularly while taking this medication, especially during the initial stages of treatment.
• Patients with a history of heart disease, aortic valve stenosis, or cardiomyopathy should exercise caution and inform their doctor before starting this medication.
• Individuals with a known allergy to Amlodipine, Telmisartan, or related drugs should not take this medication.
• This medication may cause dizziness; patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may not be suitable during these periods.
• Elderly patients may be more sensitive to the side effects of this medication; close monitoring is recommended.

Following are the drug interactions for Amlodipine 10mg, Telmisartan 80mg Tablet:

• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase amlodipine levels, leading to enhanced blood pressure-lowering effects.
• Telmisartan may have reduced effectiveness when used with NSAIDs (e.g., ibuprofen, naproxen), potentially decreasing its blood pressure-lowering effect.
• Amlodipine may increase the effects of antihypertensive agents, leading to excessive blood pressure reduction.
• Use with diuretics may have additive effects, increasing the risk of hypotension.
• Grapefruit juice can inhibit the metabolism of amlodipine, resulting in higher drug levels and increased side effects.
• Telmisartan may increase lithium levels, requiring monitoring of lithium concentrations.
• Caution with potassium-sparing diuretics or potassium supplements as telmisartan may increase potassium levels.
• Amlodipine may have enhanced effects when used with other calcium channel blockers, beta-blockers, or alpha-blockers.

Following are the food interactions for Amlodipine 10mg and Telmisartan 80mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Amlodipine, potentially leading to increased drug levels in the blood. This can cause a drop in blood pressure and increase the risk of side effects.
• Avoid excessive alcohol consumption while taking this medication as it may further lower blood pressure and increase side effects such as dizziness and lightheadedness.
• Do not consume potassium-rich foods like bananas, oranges, and spinach in large amounts, as Telmisartan can increase potassium levels, and excessive intake may lead to hyperkalemia.
• Limit the intake of foods high in sodium, such as processed and canned foods, as Telmisartan is a blood pressure medication, and a high-sodium diet may reduce its effectiveness.
• Avoid or limit the use of herbal supplements like St. John's Wort, as they can interfere with the metabolism of both Amlodipine and Telmisartan.
• Consume a balanced diet with moderate amounts of fruits, vegetables, whole grains, and lean proteins to support overall health while taking this medication.
• Stay hydrated by drinking enough water, as dehydration can affect blood pressure and kidney function.
• Avoid excessive caffeine intake, as it may interact with Amlodipine and increase the risk of palpitations or irregular heart rhythms.

Amlodipine 10mg, Telmisartan 80mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The medication should be kept in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid exposure to extreme temperatures, so refrain from storing it in hot or humid environments like bathrooms or near heat sources. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not flush or pour it down the drain; consult a pharmacist for guidance on safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Amlodipine 10mg and Telmisartan 80mg Tablet:

• Consult your doctor before use, especially if you have liver or kidney issues.
• Take the tablet at the same time each day for consistent results.
• Swallow the tablet whole with a full glass of water.
• Avoid cutting, crushing, or chewing the tablet.
• Do not stop taking the medication without consulting your doctor.
• Inform your doctor about all medications you are currently taking.
• Store in a cool, dry place, away from direct sunlight and moisture.
• Keep out of reach of children and pets.