Amgydex (3/1mg) 3.5g Eye Ointment

Dexamethasone, a potent synthetic corticosteroid, exerts its anti-inflammatory effects by binding to cytoplasmic glucocorticoid receptors, altering gene expression and suppressing the production of various pro-inflammatory mediators. This inhibits the release of inflammatory substances, reduces capillary permeability, and stabilizes cell membranes, thereby reducing inflammation and associated symptoms. Tobramycin, an aminoglycoside antibiotic, acts by binding to specific receptor sites on the bacterial cell membrane, disrupting protein synthesis. It primarily targets the 30S ribosomal subunit of susceptible bacteria, leading to the misreading of t-RNA, inhibiting protein synthesis, and ultimately causing bacterial cell death. The combination of dexamethasone and tobramycin in an ointment form allows for the simultaneous treatment of inflammation and bacterial infections, providing both therapeutic benefits and potentially reducing treatment duration.

Dexamethasone, Tobramycin

Corticosteroid, Antibiotic

Ointment

The following are the uses of Dexamethasone, Tobramycin Ointment:

• Used for treating severe eye infections, especially those caused by bacteria.
• Used for reducing inflammation and preventing scarring in eye injuries or post-surgery.
• Used for managing inflammatory eye conditions like conjunctivitis and uveitis.
• Used for preventing infection and promoting healing after eye surgeries.
• Used for treating corneal ulcers and infections.
• Used for controlling allergic eye responses and reducing associated symptoms.
• Used for managing eye pain and light sensitivity in certain conditions.
• Used for improving eye comfort and visual outcomes in various ocular surface diseases.

To be taken as per doctor's prescription

In the case of an overdose of Dexamethasone, prompt medical attention is necessary as excessive use can lead to serious side effects, including severe allergic reactions, vision problems, and adrenal gland suppression. For Tobramycin Ointment, an overdose is less likely to cause systemic issues but may result in local skin irritation or allergic reactions. It is important to seek medical advice and provide information on the amount and route of the overdose to ensure appropriate treatment and management of potential adverse effects.

In the case of a missed dose of Dexamethasone, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Tobramycin Ointment, if you forget to apply a dose, apply it as soon as you remember. If it's close to the time for your next application, skip the missed dose and continue with your regular schedule. Avoid applying extra ointment to make up for the missed dose.

To apply the Dexamethasone, Tobramycin Ointment, clean your hands, and gently pull down the lower eyelid to create a pocket, squeeze a thin strip of ointment into the pocket, and release the eyelid gently to spread the ointment across the eye surface, repeating this process as directed by your healthcare provider, typically two to four times a day.

Following are the conditions or situations when Dexamethasone, Tobramycin Ointment should not be used:

• Should not be used if you have a known allergy to Dexamethasone, Tobramycin, or any other similar antibiotics.
• Avoid using this medication if you have a viral, fungal, or parasitic infection, as it is only effective against bacterial infections.
• Not recommended for individuals with a history of hypersensitivity or severe reactions to any corticosteroids.
• Do not use if you have a recent history of ocular surgery, such as cataract extraction or glaucoma surgery.
• Contraindicated in individuals with untreated bacterial, fungal, or viral infections of the eye.
• Not suitable for patients with a history of corneal ulcers or perforations.
• Should not be used if you have a known or suspected fungal eye infection.

The side effects of Dexamethasone, Tobramycin Ointment may include:

• Elevated intraocular pressure (in the eyes)
• Allergic reactions such as itching, redness, or swelling at the application site
• Skin irritation or dryness
• Thinning of the skin
• Delayed wound healing
• Changes in skin pigmentation (lightening or darkening)
• Increased susceptibility to infections
• Eye discomfort or irritation

Following are the precautions and warnings for Dexamethasone, Tobramycin Ointment:

• Do not use this medication if you are allergic to dexamethasone, tobramycin, or any other ingredients in the ointment.
• Exercise caution if you have a history of eye infections or injuries; consult an eye specialist before use.
• This medication is for external use on the eyes only; do not ingest or insert into the ear or nose.
• Avoid contact with eyes during application, and wash your hands thoroughly before and after use.
• Prolonged use may lead to increased eye pressure and potential damage; regular eye pressure checks are necessary.
• Discontinue use and seek medical attention if you experience severe eye pain, changes in vision, or signs of infection.
• Keep out of reach of children and pets.

Following are the drug interactions for Dexamethasone, Tobramycin Ointment:

• Dexamethasone can enhance the effect of other immunosuppressants, increasing the risk of infection.
• Concomitant use with other antibiotics may increase the risk of bacterial resistance.
• Tobramycin can interact with other aminoglycoside antibiotics, potentially leading to increased ototoxicity and nephrotoxicity.
• The effect of dexamethasone may be reduced by enzyme inducers like rifampicin, requiring close monitoring.
• Live vaccines should be avoided during treatment due to potential reduced effectiveness.
• Antifungal agents like ketoconazole can increase Tobramycin levels, requiring dose adjustments.
• NSAIDs and corticosteroids like dexamethasone may increase the risk of gastrointestinal bleeding and ulceration.

Following are the food interactions for Dexamethasone, Tobramycin Ointment:

• Dexamethasone can increase appetite, so patients should be cautious of excessive calorie intake and monitor their diet to maintain a healthy weight.
• High-sodium foods should be limited as Dexamethasone can cause sodium retention, leading to increased blood pressure.
• Foods rich in potassium like bananas, oranges, and spinach are beneficial as Dexamethasone may cause potassium depletion.
• Tobramycin absorption is not significantly affected by food, so it can be used without regard to meals.
• Avoid consuming alcohol as it may increase the risk of side effects such as gastrointestinal issues and dizziness.
• Maintain a balanced diet to support overall health and manage potential side effects like weight gain, fluid retention, and electrolyte imbalances.
• No specific food restrictions are necessary, but patients should follow a healthy diet as advised by their healthcare provider.

Dexamethasone and Tobramycin Ointment should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing it to extreme temperatures by not storing it in hot or humid environments like bathrooms or near heat sources. Regularly check the expiration date, and if the ointment is past its prime, do not flush or drain it; instead, consult a pharmacist or healthcare professional for safe disposal methods. Lastly, ensure the medication is kept securely away from children to prevent accidental contact or ingestion.

No

Following are the quick tips for Dexamethasone and Tobramycin Ointment:

• Wash your hands before and after applying the ointment to maintain hygiene.
• Ensure the affected area is clean and dry before application.
• Apply a thin layer as directed, covering the entire affected area.
• Avoid applying to healthy skin, and do not use more than prescribed.
• Do not cover the treated area with a bandage unless instructed by your doctor.
• If using other eye medications, allow at least 5 minutes between applications to prevent dilution.
• Store the ointment at room temperature, away from direct sunlight and moisture.