Avil (25mg) 2ml, 50 Ampoule Injections

Pheniramine maleate, an antihistamine, exerts its effect by competitively blocking H1-receptor sites on cellular membranes. This inhibits the action of histamine, a key mediator of allergic reactions. By preventing histamine from binding to its receptors, pheniramine maleate effectively reduces symptoms associated with allergic responses, including sneezing, itching, and nasal congestion. This mechanism of action makes it useful in the management of various allergic conditions.

Antihistamine

Injection

The following are the uses of Pheniramine Maleate injection:

• Used for treating severe allergic reactions, including anaphylaxis, to provide rapid relief from life-threatening symptoms.
• Used for controlling severe allergic reactions during surgical procedures to ensure patient safety.
• Used for managing allergic symptoms associated with blood transfusions, preventing adverse reactions.
• Used for treating allergic reactions caused by insect bites or stings, reducing swelling and discomfort.
• Used for providing relief from allergic conjunctivitis, reducing eye itching and redness.
• Used for managing acute allergic reactions triggered by food, medication, or environmental factors.
• Used for controlling allergic symptoms in emergency situations, offering immediate relief.

Take as per doctor's prescription

In the case of an overdose of Pheniramine Maleate injection, symptoms may include severe drowsiness, confusion, rapid heartbeat, dry mouth, and difficulty in urination. Medical attention should be sought immediately if an overdose is suspected. Prompt treatment can help manage these symptoms and prevent potential complications. It is crucial to administer the correct dosage as prescribed by a healthcare professional to avoid such incidents.

In the case of a missed dose of Pheniramine Maleate injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracking app to help you stay on track with your treatment plan. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer the Pheniramine Maleate injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

Here are the conditions or situations when Pheniramine Maleate injection should not be administered:

• Allergic Reactions Should not be used in individuals with a known or suspected allergy or hypersensitivity to Pheniramine Maleate or other similar antihistamines.
• Newborns and Infants Contraindicated in newborns or premature infants due to the potential risk of respiratory depression.
• Asthma Exacerbation Not recommended for patients with a history of asthma, as it may worsen breathing difficulties.
• Narrow-Angle Glaucoma Should not be used in individuals with narrow-angle glaucoma or increased intraocular pressure.
• Prostate Enlargement Contraindicated in patients with enlarged prostate conditions, as it can worsen urinary retention.
• Stomach Ulcers Not suitable for individuals with stomach ulcers or gastrointestinal obstructions.
• Severe Cardiovascular Disease Should be avoided in patients with severe heart conditions, such as coronary artery disease or uncontrolled hypertension.
• Liver or Kidney Impairment Pheniramine Maleate should not be used in patients with severe liver or kidney disease.
• Monoamine Oxidase Inhibitor (MAOI) Use Should not be administered to patients taking MAOIs or within 14 days of stopping MAOIs, as it may cause severe side effects.
• Breastfeeding Contraindicated in breastfeeding women, as it can pass into breast milk and harm the nursing infant.
• Epilepsy or Seizure Disorders Not recommended for individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Before Surgery Should be avoided in patients scheduled for surgery, and the treating physician should be informed about recent Pheniramine Maleate use.

The side effects of Pheniramine Maleate injection may include:

• Drowsiness
• Sedation
• Dry mouth
• Blurred vision
• Dizziness
• Nausea and vomiting
• Difficulty in urination
• Hypersensitivity reactions

Following are the precautions and warnings for Pheniramine Maleate injection:

• Allergic reactions may occur; patients with known allergies to pheniramine or related compounds should use with caution.
• This medication can cause drowsiness or dizziness, so patients should not drive or operate heavy machinery until the effects are known.
• Elderly patients may be more sensitive to the side effects, particularly confusion, dizziness, and low blood pressure.
• Pheniramine Maleate should be used with caution in patients with heart disease, high blood pressure, or an overactive thyroid as it may exacerbate these conditions.
• It may cause blurred vision or dry mouth; patients should be aware of these potential side effects.
• Not recommended for use in children under 2 years of age due to potential for serious side effects.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication as it may pass into breast milk.

Following are the drug interactions for Pheniramine Maleate injection:

• Alcohol, CNS depressants, or other antihistamines can increase drowsiness and should be avoided or used with caution.
• Monoamine oxidase inhibitors (MAOIs) may interact, causing increased side effects and potentially serious reactions.
• Beta-blockers can have an additive effect on blood pressure and heart rate.
• Anticonvulsants may have reduced efficacy when used with Pheniramine.
• Tricyclic antidepressants and barbiturates may require dosage adjustments when used concomitantly.
• Drugs that prolong QT interval may have enhanced effects, leading to serious heart rhythm issues.
• Antihypertensive medications may need dosage adjustments due to potential additive hypotensive effects.

Following are the food interactions for Pheniramine Maleate injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and drowsiness.
• Grapefruit and its juice should be consumed with caution as they can interfere with the medication's metabolism, leading to increased drug levels in the body.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may enhance the medication's stimulant effects, causing restlessness and insomnia.
• High-fat meals can potentially delay the absorption of Pheniramine Maleate, affecting the onset of its action.
• Spicy foods may increase the risk of stomach irritation, especially if the injection is administered orally.
• Avoid eating or drinking anything with high sugar content, as it may interfere with the medication's effectiveness, especially in diabetic patients.
• Consuming foods rich in vitamin C, like citrus fruits, may enhance the antioxidant effects of Pheniramine Maleate.
• Always follow the healthcare provider's advice regarding dietary restrictions and recommendations during the treatment period.

Pheniramine Maleate injection should be stored in a controlled environment, preferably in a clean and dry storage area at room temperature, typically between 20°C and 25°C (68°F to 77°F). Protect the injection vials from direct sunlight, heat, and moisture, as these factors can degrade the medication. Always keep the medication in its original packaging, ensuring the seal is intact, to maintain its sterility. When disposing of unused or expired Pheniramine Maleate injection, do not discard it via household waste or sewage systems. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure it is done safely and in an environmentally friendly manner. Keep the medication securely stored, out of the reach of children and pets, to prevent accidental exposure.

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Following are the quick tips for Pheniramine Maleate injection:

• Administer the injection under medical supervision for proper administration.
• Ensure the injection is given at the correct dosage as prescribed.
• Verify the medication's identity and expiry date before use.
• Use a sterile syringe and needle for the injection to prevent infection.
• Dispose of used needles and syringes safely in a puncture-proof container.
• If you experience any adverse reactions, inform your healthcare provider immediately.
• Store the medication as directed on the package insert, typically at room temperature and away from light.