Avodart (0.5mg) 30 Capsules

Dutasteride, the active ingredient in the 0.5mg capsule, acts by inhibiting the enzyme 5-alpha reductase. This enzyme is responsible for converting testosterone into dihydrotestosterone (DHT) in the body. By blocking this conversion, dutasteride significantly reduces DHT levels, which is a key hormone involved in male pattern hair loss and prostate growth. Specifically, dutasteride inhibits both Type I and Type II 5-alpha reductase isoenzymes, leading to a more comprehensive suppression of DHT production compared to other 5-alpha reductase inhibitors. This mechanism of action makes dutasteride effective in treating conditions influenced by DHT, such as benign prostatic hyperplasia and androgenetic alopecia.

Dutasteride 0.5mg

5-alpha-reductase inhibitor.

Capsule

The following are the uses of Dutasteride 0.5mg Capsule:

• Used for treating benign prostatic hyperplasia (BPH), reducing enlarged prostate size and relieving associated symptoms.
• Used to lower and control high levels of DHT (Dihydrotestosterone), a hormone linked to hair loss.
• Used to slow down and potentially reverse male pattern baldness, promoting hair regrowth.
• Used to manage excessive hair growth in women with conditions like hirsutism.
• Used to improve urinary symptoms and reduce the risk of prostate surgery.
• Used as a long-term treatment for maintaining prostate health.
• Used to enhance the effectiveness of certain hair regrowth treatments.

In the case of an overdose of Dutasteride 0.5mg Capsules, it is important to recognize the potential risks. Overdosing may lead to an increased incidence of side effects, including gastrointestinal issues, dizziness, and fatigue. Promptly contact a healthcare professional or a poison control center for guidance on managing the overdose and to determine the appropriate treatment. Timely intervention can help mitigate the potential adverse effects and ensure the patient's well-being.

In the case of a missed dose of Dutasteride 0.5mg Capsule, it is recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication without affecting the treatment outcome. It's important to maintain a consistent dosing routine for the medication's effectiveness.

To take Dutasteride 0.5mg Capsules, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the instructions provided by your healthcare professional, typically prescribed for once-daily use.

Following are the conditions when Dutasteride 0.5mg Capsule should not be used:

• Must not be taken by individuals who are allergic to Dutasteride or other 5-alpha reductase inhibitors.
• Contraindicated in women and children.
• Should not be used by individuals with a history of liver disease or liver problems.
• Not recommended for those who are pregnant or planning to become pregnant, as it can cause harm to the developing male fetus.
• Avoid using this medication if you have a rare inherited condition known as galactose intolerance.
• Do not take if you have a severe allergy to peanuts, soybeans, or related products.
• Dutasteride is not intended for use in women, especially those who are or may become pregnant.

The side effects of Dutasteride 0.5mg Capsule may include:

• Decreased libido or sexual desire
• Erectile dysfunction
• Decreased semen release during ejaculation
• Breast tenderness or enlargement (gynecomastia)
• Skin rash
• Dizziness
• Fatigue
• Testicular pain

Following are the precautions and warnings for Dutasteride 0.5mg Capsule:

• Not recommended for women, especially those who are or may become pregnant. It can cause birth defects in a developing male fetus.
• Men should not donate blood until at least 6 months after stopping Dutasteride to prevent potential fetal exposure.
• Blood tests may be required to monitor liver function and prostate-specific antigen (PSA) levels during treatment.
• May cause a temporary increase in the risk of prostate cancer progression, regular digital rectal examinations and PSA tests are recommended.
• Patients with liver disease or a history of liver problems should use with caution, as it can affect liver function.
• Not intended for use in children or adolescents, as safety and efficacy have not been established in this population.
• Can cause dizziness and lightheadedness, so caution should be exercised when performing activities that require alertness.

Following are the drug interactions for Dutasteride 0.5mg Capsule:

• Dutasteride can interact with alpha-blockers, leading to potential hypotension and dizziness.
• Avoid using other 5-alpha reductase inhibitors like finasteride, as it may increase the risk of sexual dysfunction and other side effects.
• Drugs that are highly protein-bound, such as warfarin, may have altered distribution when taken with dutasteride.
• Dutasteride may increase the concentration of midazolam, a sedative, requiring dosage adjustments.
• The absorption of dutasteride can be reduced by cholesterol-lowering medications like cholestyramine.
• Drugs metabolized by CYP3A4 enzymes may have altered metabolism when co-administered with dutasteride.
• Caution is advised when using dutasteride with diuretics, as it may increase the risk of postural hypotension.
• Avoid using other drugs that lower PSA levels, as dutasteride also affects PSA, making it difficult to interpret PSA test results.

Following are the food interactions to be aware of when taking Dutasteride 0.5mg Capsules:

• Avoid consuming grapefruit or grapefruit juice as they may interfere with the metabolism of Dutasteride, potentially leading to increased drug levels in the body.
• Limit alcohol consumption as it may increase the risk of liver-related side effects.
• Avoid high-fat meals as they can decrease the absorption of Dutasteride, reducing its effectiveness.
• Avoid or limit the intake of foods rich in vitamin K (e.g., leafy greens, broccoli) as Dutasteride may alter the metabolism of vitamin K-dependent clotting factors.
• There is no significant interaction with dairy products, but some individuals may prefer to take the capsule with water to avoid any potential interference with absorption.
• Avoid excessive caffeine intake as it may increase heart rate and blood pressure, which could be a concern for individuals with cardiovascular conditions.
• Consuming a balanced diet is generally recommended to maintain overall health and support the medication's effectiveness.
• Always consult your healthcare provider for personalized advice regarding food and medication interactions.

Dutasteride 0.5mg capsules should be stored in a cool, dry place, preferably at room temperature (around 20-25°C), ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid exposing the capsules to extreme temperatures, so steer clear of storing them in the bathroom or near heat-emitting appliances. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it via household waste or wastewater systems; instead, seek guidance from a pharmacist or healthcare professional for the recommended disposal method in your area. Keep this medication securely stored, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Dutasteride 0.5mg Capsule:

• Swallow the capsule whole with a full glass of water; do not crush, chew, or open it.
• Take the capsule at the same time each day to maintain consistent levels.
• Dutasteride may take several months to show noticeable effects, so be patient and consistent.
• Avoid donating blood until at least 6 months after stopping Dutasteride to prevent potential risks to pregnant women.
• Inform your doctor if you have liver disease or are at risk of prostate cancer.
• This medication is for men only; keep it away from women and children.
• Store the capsules at room temperature, away from moisture and light.