Azopt (1%) 5ml Eye Suspension

Brinzolamide, the active ingredient in Brinzolamide Syrup/Suspension, acts as a carbonic anhydrase inhibitor. It primarily works within the eye to reduce the production of aqueous humor, a fluid that maintains intraocular pressure. By inhibiting carbonic anhydrase, brinzolamide decreases the formation of bicarbonate ions, which are essential for aqueous humor secretion. This reduction in bicarbonate ions leads to a decrease in the production of aqueous humor, resulting in lower intraocular pressure. This mechanism is crucial in managing conditions like ocular hypertension and open-angle glaucoma, where reducing intraocular pressure is a key therapeutic goal.

Brinzolamide

Carbonic anhydrase inhibitor

Suspension

The following are the uses of Brinzolamide Syrup/Suspension:

• Used for treating elevated eye pressure in patients with ocular hypertension.
• Used for managing open-angle glaucoma, helping to reduce intraocular pressure.
• Used to prevent potential vision loss by controlling eye pressure.
• Used as a carbonic anhydrase inhibitor, reducing aqueous humor production.
• Used as an adjunct to eye drops, providing an alternative administration method.
• Used for patients who struggle with eye drop administration, ensuring consistent dosing.
• Used to improve medication adherence, especially for those with dexterity issues.

In the case of an overdose of Brinzolamide Syrup/Suspension, it is important to remain calm and seek medical advice promptly. Symptoms may include increased eye pressure, blurred vision, or gastrointestinal discomfort. Promptly contact a healthcare professional or poison control center for guidance. They will provide specific instructions and may recommend monitoring vital signs and providing supportive care until any adverse effects subside.

In the case of a missed dose of Brinzolamide Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss several doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions for catching up on missed doses.

To take Brinzolamide Syrup/Suspension, shake the bottle well, measure the prescribed dose with the provided dosing device, and administer it orally, typically twice a day, or as directed by your healthcare professional, regardless of meals.

Following are the conditions when Brinzolamide Syrup/Suspension should not be used:

• Do not use if the patient is allergic to any of the ingredients in the medication.
• Avoid using in patients with severe kidney or liver disease.
• Not suitable for individuals with respiratory diseases or breathing problems.
• Contraindicated in patients with a history of sulfa drug allergies.
• Should not be used if the patient has closed-angle glaucoma or a history of asthmatic reactions.
• Not recommended for children under 2 years of age.
• Avoid using in patients with a history of kidney stones or metabolic acidosis.

The side effects of Brinzolamide Syrup/Suspension may include:

• Bitter or unusual taste in the mouth
• Eye discomfort or irritation
• Dry mouth
• Fatigue and weakness
• Headache
• Nausea and vomiting
• Blurred vision or changes in vision
• Allergic reactions (e.g., rash, itching, difficulty breathing)

Following are the precautions and warnings for Brinzolamide Syrup/Suspension:

• This medication is intended for ocular use only and should never be taken orally.
• Patients with a history of severe respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), should use Brinzolamide with caution as it may cause respiratory side effects.
• Avoid using Brinzolamide if you have a known allergy to any of its ingredients, including preservatives.
• If you wear contact lenses, consult your doctor for proper lens care instructions, as this medication may contain preservatives that can be absorbed by soft contact lenses.
• Brinzolamide may cause blurred vision or other visual disturbances temporarily after administration. Avoid driving or operating heavy machinery until you feel comfortable and your vision is clear.
• This medication is not recommended for children below 2 years of age unless prescribed by a healthcare professional.
• Pregnant and breastfeeding women should consult their doctor before using Brinzolamide as its effects during these periods are not extensively studied.
• Store Brinzolamide Syrup/Suspension at room temperature, away from direct sunlight and moisture, and keep out of reach of children.

Following are the drug interactions for Brinzolamide Syrup/Suspension:

• Carbonic anhydrase inhibitors like acetazolamide may enhance the intraocular effects of brinzolamide, leading to increased ocular hypotensive effects.
• Brinzolamide can increase the ocular concentration of other carbonic anhydrase inhibitors, potentially causing systemic effects.
• Concurrent use with other topical ophthalmic medications may result in altered intraocular pressure effects.
• Brinzolamide may interact with oral carbonic anhydrase inhibitors, such as methazolamide, requiring close monitoring of serum electrolyte levels.
• The absorption of brinzolamide can be affected by ocular medications containing ion exchange resins, potentially reducing its efficacy.
• Systemic absorption of brinzolamide can be influenced by drugs that alter ocular blood flow or corneal permeability.
• Caution is advised when using Brinzolamide with medications that affect the cornea, as it may impact corneal endothelial cell density.

Following are the food interactions to consider with Brinzolamide Syrup/Suspension:

• Avoid consuming excessive amounts of salt or salty foods as they can reduce the effectiveness of Brinzolamide in controlling eye pressure.
• Limit the intake of high-fat meals as they can potentially delay the absorption of Brinzolamide, leading to a slight delay in the onset of action.
• It is generally recommended to avoid consuming alcohol during the use of Brinzolamide as it may cause temporary blurring of vision.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of certain medications, although there is no direct interaction reported with Brinzolamide.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks should be consumed in moderation as they may temporarily increase eye pressure.
• Avoid excessive consumption of sugary foods and beverages, as maintaining a healthy diet can support overall eye health.
• Always inform your healthcare provider about your dietary habits to ensure the best management of your eye condition.

Brinzolamide Syrup/Suspension requires careful storage and disposal to maintain its integrity and ensure safety. Store the medication in a cool, dry area at room temperature, shielded from direct sunlight and moisture. Keep the container tightly sealed to prevent contamination, and avoid storing it in the bathroom or near heat sources, as temperature fluctuations can impact its effectiveness. Prior to use, verify the expiration date, and for proper disposal of unused or expired syrup, consult a pharmacist or healthcare provider, avoiding improper disposal methods like flushing or pouring down drains. Additionally, keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Brinzolamide Syrup/Suspension:

• Consult your doctor for the prescribed dosage, ensuring optimal results.
• Before each use, shake the bottle vigorously to maintain a consistent mixture.
• Administer the syrup with water; avoid tea, coffee, or dairy for better absorption.
• Maintain a consistent routine by taking the medication at the same time daily.
• To reduce potential side effects, consider taking the medication with food.
• Store the syrup safely away from children to prevent accidental consumption.
• Always complete the full course of medication as directed by your healthcare provider.