Brino (250mg) 20 Capsules

Tranexamic acid, with a typical dosage strength of 250mg in capsule form, operates through a specific mechanism of action. It is a synthetic derivative of the amino acid lysine and acts as a potent antifibrinolytic agent. The primary effect of tranexamic acid is to competitively inhibit the activation of plasminogen to plasmin, a key enzyme responsible for the breakdown of blood clots. By blocking the lysine binding sites on plasminogen, it prevents the conversion of plasminogen to plasmin, thereby inhibiting fibrinolysis. This action helps to stabilize existing blood clots and promotes hemostasis by maintaining the integrity of formed fibrin clots, particularly in situations where excessive bleeding or fibrinolysis is occurring. This mechanism makes tranexamic acid effective in various clinical settings for controlling bleeding and promoting clot stability.

Fibrinolysis inhibitor.

Capsule

The following are the uses of Tranexamic Acid 250mg Capsule:

• Used for controlling heavy menstrual bleeding in women with inherited bleeding disorders.
• Used to prevent excessive bleeding during and after dental procedures in patients with bleeding disorders.
• Used in trauma patients to control bleeding and reduce the need for blood transfusions.
• Used for managing bleeding after childbirth (postpartum hemorrhage).
• Used in orthopedic surgeries to minimize blood loss and improve outcomes.
• Used to treat and prevent bleeding in patients with hemophilia.
• Used as an adjunct therapy for managing bleeding in patients undergoing cardiac surgery.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For heavy menstrual bleeding (menorrhagia)- Take 1 tablet of Tranexamic Acid 250mg 3 times a day, ideally at mealtimes to reduce stomach upset.
• For thrombocytopenia (low platelet count)- The dose will depend on the severity of your condition and your doctor's assessment. The typical starting dose is 1g (1,000mg) daily, divided into 3 smaller doses of 333mg taken at mealtimes. Your doctor may adjust this dose depending on your response and tolerance.
• For dental surgery- The recommended dose is 1 tablet of Tranexamic Acid 250mg taken 2 hours before surgery, followed by another tablet after an hour, and then a third tablet 2 hours after the surgery. This regimen helps reduce the risk of bleeding during and after the procedure.

In the case of an overdose of Tranexamic Acid 250mg Capsules, individuals may experience various symptoms. These can include nausea, vomiting, diarrhea, and in severe cases, seizures or a drop in blood pressure. If an overdose is suspected, immediate medical assistance should be sought. Prompt treatment can help manage symptoms and prevent potential complications, ensuring the best possible outcome for the patient. It is crucial to act swiftly and consult healthcare professionals for appropriate guidance.

In the case of a missed dose of Tranexamic Acid 250mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. It is recommended to take the medication with food to minimize stomach upset. Consult your healthcare provider if you frequently miss doses or are unsure about how to manage missed doses.

To take Tranexamic Acid 250mg Capsule, swallow the capsule whole with water, preferably after a meal or as directed by your healthcare professional, following the prescribed dosage and treatment duration for your specific medical condition.

Tranexamic Acid 250mg Capsule should not be used in the following conditions or situations:

• Do not take if you have a known allergy or hypersensitivity to Tranexamic Acid or any other related compounds.
• Contraindicated in individuals with active thromboembolic disease or a history of venous or arterial thrombosis.
• Should not be used if you have a bleeding disorder or are currently experiencing abnormal bleeding that is not due to enhanced fibrinolysis.
• Not recommended for patients with severe renal impairment or end-stage renal disease.
• Avoid using if you have a history of seizures or are at high risk for seizures.
• Do not use in patients with disseminated intravascular coagulation (DIC) or intravascular clotting.
• Contraindicated in individuals with a history of blood clots in the legs, lungs, or other parts of the body.

The side effects of Tranexamic Acid 250mg Capsule may include:

• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Visual disturbances (blurred vision)
• Skin rash or itching
• Fatigue and weakness
• Blood clots (in rare cases)

Following are the precautions and warnings for Tranexamic Acid 250mg Capsule:

• Avoid using this medication if you have a history of blood clots, deep vein thrombosis, or pulmonary embolism, as it may increase the risk of clotting.
• Patients with kidney or liver disease should exercise caution and consult a doctor, as the dosage may need adjustment.
• Elderly patients may be more susceptible to side effects; regular monitoring is recommended.
• Do not use Tranexamic Acid if you are pregnant or breastfeeding without medical advice, as it may have potential risks.
• If you are scheduled for any surgery, inform your doctor about your use of this medication.
• This medication may cause dizziness or visual disturbances; avoid driving or operating heavy machinery if affected.
• Stop taking the medication and seek medical attention if you experience any signs of allergic reaction, such as rash, itching, or difficulty breathing.

Following are the drug interactions for Tranexamic Acid 250mg Capsule:

• May reduce the effectiveness of hormonal contraceptives, so additional non-hormonal methods are recommended.
• Increased risk of thrombosis when combined with estrogen or combined oral contraceptives.
• Concomitant use with anti-platelet drugs or anticoagulants can enhance bleeding risk.
• Potential interaction with fibrinolytic agents, possibly reducing their efficacy.
• The risk of renal toxicity is heightened when used with nephrotoxic drugs.
• Anticonvulsants may lower tranexamic acid levels, necessitating dosage adjustments.
• NSAIDs can increase the likelihood of gastrointestinal bleeding.

Following are the food interactions for Tranexamic Acid 250mg Capsule:

• Avoid consuming foods or beverages with high vitamin K content like leafy green vegetables (spinach, kale), broccoli, Brussels sprouts, and liver products. Vitamin K can reduce the effectiveness of Tranexamic Acid.
• Alcohol should be consumed in moderation as it may increase the risk of bleeding when used with Tranexamic Acid, especially in patients with underlying bleeding disorders.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the absorption of Tranexamic Acid, potentially reducing its effectiveness.
• Avoid high-fat meals as they may delay the absorption of Tranexamic Acid, leading to a delay in its therapeutic effect.
• Salt substitutes containing potassium should be used cautiously as Tranexamic Acid may increase potassium levels in the body.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may increase the risk of side effects such as nervousness, insomnia, and rapid heartbeat when used with Tranexamic Acid.
• Avoid consuming foods with high tyramine content like aged cheeses, cured meats, and fermented foods. Tyramine can interact with Tranexamic Acid and increase blood pressure.
• Always inform your healthcare provider about your dietary habits to ensure safe and effective use of Tranexamic Acid.

Tranexamic Acid 250mg Capsules should be stored in a cool and dry place, preferably at room temperature (around 25°C), away from direct sunlight and moisture. Keep the capsules in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It is crucial not to expose the capsules to excessive heat or cold, so avoid storing them near ovens, radiators, or refrigerators. Always check the expiration date, and dispose of any unused or expired capsules responsibly. Do not flush or pour them into water sources; instead, seek advice from a pharmacist or local waste management guidelines for safe disposal. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Tranexamic Acid 250mg Capsule:

• Consult your doctor before taking this medication for personalized advice.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Take the capsule as soon as possible after an injury or as directed by your doctor.
• Avoid taking with anticoagulant medications without medical advice.
• Inform your doctor about all medications and supplements you are taking.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Do not share this medication with others, even if they have similar symptoms.

Tranexamic acid is a medication that is typically prescribed to treat or prevent excessive blood loss from wounds or during menstrual periods. It is in the category of drugs called fibrinolytics, which help stabilize blood clots and prevent excessive bleeding. While laboratory tests are not required for everyone who takes tranexamic acid, certain monitoring may be done to ensure the safety and effectiveness of the medication. This will depend on several factors, including the prescription of the medication, dosage and duration of treatment, and individual health conditions and comorbidities.Some factors that influence the need for laboratory tests include: