Brufen (400mg) 250 Tablets

Ibuprofen 400mg tablets exert their therapeutic effects primarily through their ability to inhibit the production of prostaglandins. Prostaglandins are chemicals in the body that play a key role in inflammation and pain. Ibuprofen works by blocking the enzyme cyclooxygenase (COX), which is responsible for converting arachidonic acid into prostaglandin H2, a precursor to various prostaglandins. By inhibiting COX, ibuprofen reduces the production of prostaglandins, thereby decreasing inflammation, pain, and fever. This mechanism of action makes ibuprofen an effective nonsteroidal anti-inflammatory drug (NSAID) for managing mild to moderate pain, reducing inflammation, and controlling fever associated with various conditions.

Ibuprofen 400mg

NSAID (Non-steroidal anti-inflammatory drug)

Tablet

The following are the uses of Ibuprofen 400mg Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, and backaches.
• Used to reduce inflammation and lower fever in conditions like flu, cold, or post-vaccination fever.
• Used to treat symptoms of arthritis, providing relief from pain, stiffness, and swelling.
• Used for reducing menstrual pain and discomfort during periods.
• Used to alleviate muscle aches and pains associated with sprains and strains.
• Used for treating minor injuries and sports-related inflammation.
• Used to provide temporary relief from minor aches and pains, allowing for better comfort and mobility.

200-400mg orally every 4-6 hours depending upon the severity of the pain and healthcare professional's recommendation.

In the case of an overdose of Ibuprofen 400mg Tablets, several symptoms may occur, including severe stomach pain, nausea, vomiting, and gastrointestinal bleeding. The severity of these symptoms can vary depending on the amount ingested. Prompt medical intervention is essential, as overdosing on ibuprofen can lead to potentially life-threatening complications, particularly for individuals with pre-existing medical conditions. Timely treatment and medical assessment are crucial to managing the adverse effects and ensuring the best possible outcome for the patient.

In the case of a missed dose of Ibuprofen 400mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your medication schedule. It is recommended to set reminders or alarms to help you remember to take your medication as prescribed.

To take Ibuprofen 400mg Tablets, swallow the tablet whole with a full glass of water, preferably with or after a meal, as directed by your healthcare professional, and do not crush, chew, or break the tablet.

Ibuprofen 400mg Tablet should not be used in the following conditions or situations:

• Avoid using if you have a known allergy or hypersensitivity to Ibuprofen, aspirin, or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
• Not suitable for individuals with a history of asthma attacks, hives, or other allergic reactions triggered by NSAIDs.
• Contraindicated in patients with active or recent gastrointestinal bleeding or perforation.
• Should not be used in people with severe heart failure or conditions where fluid retention is a concern.
• Avoid using if you have a history of stomach ulcers, bleeding, or other gastrointestinal disorders.
• Not recommended for individuals with severe kidney or liver disease.
• Contraindicated during the third trimester of pregnancy due to potential harm to the fetus.
• Should not be used in patients with aspirin-sensitive asthma.

The side effects of Ibuprofen 400mg Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Heartburn or indigestion
• Dizziness or lightheadedness
• Headache
• Skin rash or itching
• Increased blood pressure

Following are the precautions and warnings for Ibuprofen 400mg Tablet:

• Do not take this medication if you have a known allergy to Ibuprofen or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Individuals with a history of gastrointestinal bleeding, ulcers, or other stomach disorders should use with caution and under medical supervision.
• This medication may increase the risk of heart attack or stroke, especially with prolonged use. Do not use for extended periods without medical advice.
• Patients with hypertension, heart disease, or those who have recently undergone heart surgery should exercise caution and consult a healthcare professional before use.
• Ibuprofen can cause kidney problems; those with a history of kidney disease or taking diuretics should be closely monitored while on this medication.
• Avoid alcohol consumption while taking Ibuprofen as it may increase the risk of gastrointestinal bleeding and liver damage.
• Pregnant and breastfeeding women should consult their doctor before using Ibuprofen, as it may have potential risks for the fetus and infant.
• Always take the recommended dosage; do not exceed the prescribed dose or duration of treatment.

Following are the drug interactions for Ibuprofen 400mg Tablet:

• Aspirin or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) may increase the risk of stomach bleeding and ulcers when taken with Ibuprofen.
• Ibuprofen can reduce the blood pressure-lowering effect of ACE inhibitors, such as lisinopril or enalapril.
• It may decrease the effectiveness of diuretics or 'water pills' like furosemide or hydrochlorothiazide.
• Lithium levels can be affected by Ibuprofen, leading to potential toxicity.
• The risk of kidney damage may increase when Ibuprofen is combined with cyclosporine or tacrolimus.
• Ibuprofen may reduce the antihypertensive effect of beta-blockers like metoprolol or atenolol.
• Anticoagulants like warfarin or heparin may have their action enhanced by Ibuprofen, increasing bleeding risk.

Following are the food interactions for Ibuprofen 400mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it can increase the risk of gastrointestinal bleeding and liver problems.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Ibuprofen, potentially increasing its levels in the blood and the risk of side effects.
• Limit caffeine intake as it can increase the risk of stomach irritation and interfere with the healing process, especially if you have a stomach ulcer or gastrointestinal bleeding.
• Avoid high-sodium foods, as Ibuprofen can cause sodium and fluid retention, which may worsen conditions like hypertension and heart failure.
• Avoid high-potassium foods if you have kidney problems, as Ibuprofen can affect kidney function and lead to elevated potassium levels.
• Maintain a balanced diet rich in fiber, as Ibuprofen can sometimes cause constipation.
• Ensure adequate fluid intake to reduce the risk of kidney-related issues, especially if you have pre-existing kidney conditions.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific medical conditions or are taking other medications.

Ibuprofen 400mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring it remains protected from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storing it near heat sources like ovens or radiators. Regularly check the expiration date on the packaging, and if the tablets are no longer needed or have expired, do not flush them or pour them down the drain. Instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication securely stored, out of the reach of children, to prevent accidental consumption.

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Following are the quick tips for Ibuprofen 400mg Tablet:

• Consult a doctor for personalized dosage instructions based on your medical condition.
• Take the tablet with or after food to minimize stomach irritation.
• Swallow the tablet whole, do not crush or chew it.
• Avoid taking other NSAIDs or aspirin while on this medication.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Do not take the tablet for longer than recommended, and contact your doctor if symptoms persist.
• Store the medication at room temperature, away from moisture and light.