Calamox (0.6g) 1 Vial Injection

Co-Amoxiclav 600mg injection combines the effects of amoxicillin and clavulanic acid. Amoxicillin belongs to the penicillin-type antibiotics, and it works by inhibiting the synthesis of bacterial cell walls. It specifically targets the penicillin-binding proteins, which are essential for forming a strong cell wall structure. Clavulanic acid enhances the effectiveness of amoxicillin by inhibiting beta-lactamase enzymes produced by certain bacteria, which would otherwise render amoxicillin ineffective. Together, this combination broadens the spectrum of activity against a wide range of bacteria, including those that have developed resistance to other beta-lactam antibiotics.

Co-Amoxiclav 600mg

Penicillin combination.

Injection

The following are the uses of Co-Amoxiclav 600mg injection:

• Used for treating severe bacterial infections that require intravenous antibiotics, such as skin and soft tissue infections, respiratory tract infections, and abdominal infections.
• Used for patients with high fever and suspected bacterial infections where rapid action is necessary.
• Used in cases of community-acquired pneumonia, especially in patients with underlying health conditions.
• Used to combat bacterial infections in patients with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy.
• Used for the treatment of complicated urinary tract infections caused by susceptible bacteria.
• Used as a pre-surgical antibiotic to prevent infections during and after surgery.
• Used for patients with a history of severe allergic reactions to penicillin, as an alternative treatment option.

To be used as per doctor's prescription

In the case of an overdose of Co-Amoxiclav 600mg injection, it is important to seek medical assistance promptly. Symptoms of overdose may include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, as well as potential allergic reactions. Immediate treatment should focus on managing these symptoms and providing supportive care. Medical professionals may induce vomiting or use activated charcoal to prevent further absorption of the medication. Prompt medical intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Co-Amoxiclav 600mg injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and ensure the treatment remains effective.

To administer Co-Amoxiclav 600mg injection, prepare the medication by drawing the prescribed dose into a syringe, ensuring it is free from air bubbles, and inject it slowly into a muscle or intravenous line as directed by your healthcare professional, following the recommended dosage and administration instructions provided.

Following are the conditions when Co-Amoxiclav 600mg injection should not be administered:

• Must not be used in individuals with a known allergy to amoxicillin, clavulanic acid, penicillin, or any other beta-lactam antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to any other medications.
• Should not be used if the patient has a history of severe liver problems or jaundice associated with amoxicillin/clavulanate use.
• Not recommended for patients with mononucleosis or lymphatic leukemia.
• Avoid using in patients with a history of gastrointestinal diseases, especially colitis or antibiotic-associated colitis.
• Not suitable for individuals with a history of severe renal impairment without appropriate dose adjustment.
• Must not be administered if the patient is currently taking medications that may interact negatively with Co-Amoxiclav, such as probenecid, allopurinol, or certain anticoagulants.

The side effects of Co-Amoxiclav 600mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Allergic reactions (hives, swelling, difficulty breathing)
• Fatigue or dizziness
• Vaginal itching or discharge
• Joint pain or stiffness
• Changes in taste

Here are the precautions and warnings for Co-Amoxiclav 600mg injection:

• This medication should not be administered to individuals with a confirmed allergy to penicillins, cephalosporins, or any other beta-lactam antibiotics.
• Caution is advised for patients with a history of severe allergies, as there is a potential for cross-reactivity with other antibiotics.
• Patients with a history of gastrointestinal issues, particularly colitis, should be closely monitored as this medication may exacerbate these conditions.
• Co-Amoxiclav may reduce the effectiveness of oral contraceptives, so alternative contraceptive methods are recommended during treatment.
• Elderly patients and those with kidney impairment may require dosage adjustments to prevent potential side effects.
• Prolonged use may lead to the overgrowth of resistant bacteria or fungi, so the duration of treatment should be carefully determined.
• It is essential to complete the full course of treatment, even if symptoms improve before the medication is finished.
• If severe diarrhea occurs during or after treatment, contact your healthcare provider immediately.

Following are the drug interactions for Co-Amoxiclav 600mg injection:

• Probenecid can decrease the elimination of amoxicillin, increasing its blood levels and risk of side effects.
• Allopurinol may increase the risk of skin reactions when used with amoxicillin.
• The effectiveness of oral contraceptives may be reduced when taken with co-amoxiclav.
• Co-administration with methotrexate can increase methotrexate levels, potentially leading to toxicity.
• Concurrent use with anticoagulants like warfarin may increase the risk of bleeding.
• Co-amoxiclav can reduce the efficacy of live attenuated vaccines (e.g., oral typhoid vaccine).
• It may also interact with certain medications that affect kidney function, such as diuretics.

Following are the food interactions for Co-Amoxiclav 600mg injection:

• Avoid excessive alcohol consumption during the treatment, as it may reduce the effectiveness of the antibiotic and increase the risk of side effects like nausea and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the absorption and metabolism of the medication, potentially increasing blood levels of the drug.
• Maintain a balanced diet and ensure adequate hydration to support overall health and aid in the recovery process.
• Avoid high-fat meals before or after taking the injection, as it may delay the absorption of the medication.
• Probiotics can be beneficial to replenish healthy gut bacteria that may be affected by the antibiotic; consider consuming yogurt or supplements with your doctor's advice.
• Avoid foods or drinks that are highly acidic, as they may irritate the injection site and cause discomfort.
• There are no specific food restrictions, but a healthy diet rich in nutrients can aid in recovery and support the immune system.
• Always follow the advice of your healthcare provider regarding any dietary considerations during the treatment period.

Co-Amoxiclav 600mg injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature, ensuring it is shielded from direct sunlight and moisture. Maintain the integrity of the medication by keeping it securely sealed within its original packaging. It is crucial to avoid extreme temperatures, so refrain from placing it near heat sources like radiators or ovens. Prior to administration, verify the expiration date, and if the injection is no longer needed or has expired, proper disposal is essential. Do not attempt to dispose of it by flushing or pouring it down the drain; instead, consult your pharmacist or healthcare provider for appropriate disposal methods to minimize environmental impact. Always keep medications securely stored, out of the reach of children, to prevent accidental exposure.

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Following are the quick tips for Co-Amoxiclav 600mg Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm your medical history and allergies before injection.
• Inform your doctor if you're pregnant or breastfeeding.
• Avoid alcohol consumption during the treatment period.
• Stay hydrated and maintain a balanced diet for better recovery.
• Report any unusual symptoms or side effects to your doctor immediately.
• Complete the full course as prescribed, even if you feel better earlier.