Calamox (1.2g) Injection

Co-Amoxiclav 1200mg injection combines the effects of amoxicillin, a beta-lactam antibiotic, and clavulanic acid, a beta-lactamase inhibitor. Amoxicillin works by inhibiting the synthesis of bacterial cell walls, specifically targeting the penicillin-binding proteins (PBPs) involved in cell wall cross-linking. This interference weakens the cell wall, leading to bacterial cell lysis. However, some bacteria produce beta-lactamase enzymes that can break down amoxicillin, rendering it ineffective. This is where clavulanic acid comes into play; it competitively inhibits beta-lactamase enzymes, protecting amoxicillin from degradation and allowing it to exert its bactericidal effect. Together, this combination broadens the spectrum of activity against a wide range of bacteria, including those that produce beta-lactamases.

Co-Amoxiclav 1200mg

Antibiotic.

Injection

The following are the uses of Co-Amoxiclav 1200mg injection:

• Used for treating severe bacterial infections such as pneumonia and skin or soft tissue infections.
• Used for rapid action in critical conditions like sepsis or post-surgery infections.
• Used for cases where high oral dosage is not feasible or for patients unable to take oral medication.
• Used for broad-spectrum coverage against a wide range of bacteria, including penicillin-resistant strains.
• Used for community-acquired respiratory tract infections that require aggressive treatment.
• Used for managing infections in patients with weakened immune systems or underlying health conditions.
• Used for preventing and controlling infections in high-risk situations, such as before surgeries.

To be used as per doctor's prescription

In the case of an overdose of Co-Amoxiclav 1200mg injection, seek medical assistance promptly. Overdose symptoms may include gastrointestinal disturbances, skin rashes, and potential allergic reactions. The severity of symptoms can vary based on individual sensitivity and the amount ingested. It is vital to contact a healthcare professional or go to the nearest emergency department for appropriate treatment and monitoring to ensure the best possible outcome.

In the case of a missed dose of Co-Amoxiclav 1200mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication schedule. It is crucial to maintain a consistent dosing routine for the medication's effectiveness.

To administer Co-Amoxiclav 1200mg injection, gently swirl the vial to ensure the powder is fully dissolved, then using a sterile syringe, draw the prescribed dose and inject it slowly into the muscle, following the instructions provided by your healthcare professional.

Following are the conditions/situations when Co-Amoxiclav 1200mg injection should not be administered:

• Must not be used in individuals with a known allergy to amoxicillin, clavulanic acid, penicillin, or any other beta-lactam antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to any antibiotics.
• Should not be used in patients with a history of jaundice or liver problems caused by amoxicillin/clavulanate.
• Not recommended for individuals with mononucleosis.
• Avoid in patients with severe kidney disease or those on dialysis.
• Do not administer if the patient has a history of severe diarrhea or colitis caused by antibiotics.
• Contraindicated during breastfeeding, as amoxicillin and clavulanic acid may pass into breast milk.

The side effects of Co-Amoxiclav 1200mg injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rash or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Vaginal itching or discharge
• Headache
• Dizziness
• Abnormal liver function tests

Following are the precautions and warnings:

• Co-Amoxiclav 1200mg injection should not be administered to individuals with a known allergy to penicillins, cephalosporins, or any other component of the medication.
• This injection is intended for intravenous use only and should be administered by trained medical professionals.
• Caution is advised in patients with a history of kidney or liver disease, as dosage adjustments may be necessary to prevent potential complications.
• It is important to ensure adequate hydration during the treatment period to reduce the risk of kidney-related side effects.
• Patients with a history of gastrointestinal issues, especially colitis, should be closely monitored, as Co-Amoxiclav may cause gastrointestinal disturbances.
• Prolonged use of this medication may lead to the overgrowth of non-susceptible bacteria or fungi, so the duration of treatment should be carefully determined.
• Pregnant and breastfeeding women should only use Co-Amoxiclav if the potential benefits outweigh the risks, and under the supervision of a healthcare professional.
• Discontinue the injection immediately if severe skin reactions or allergic reactions occur, and seek medical attention promptly.

Following are the drug interactions for Co-Amoxiclav 1200mg injection:

• Probenecid slows down the removal of amoxicillin and clavulanic acid from the body, leading to higher levels of these drugs.
• Concomitant use with certain antibiotics like chloramphenicol or macrolides may reduce the effectiveness of Co-Amoxiclav.
• It may decrease the effectiveness of oral contraceptives, requiring alternative birth control methods.
• The risk of bleeding can increase when taken with anticoagulants like warfarin.
• Co-Amoxiclav can affect the metabolism of certain medications, including methotrexate, increasing their concentration and potential toxicity.
• Allopurinol can increase the risk of allergic reactions when used with Co-Amoxiclav.
• When combined with live vaccines, Co-Amoxiclav may reduce their effectiveness.

Following are the food interactions for Co-Amoxiclav 1200mg injection:

• Avoid consuming alcohol during the medication period as it may cause liver-related side effects and increase the risk of gastrointestinal issues.
• Maintain a balanced diet, ensuring adequate fluid intake to support overall health and aid in fighting the infection.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the absorption and metabolism of the medication.
• Dairy products like milk, yogurt, and cheese can sometimes interfere with the absorption of antibiotics, so consider spacing these foods apart from medication timing.
• Ensure a sufficient intake of vitamin K-rich foods like leafy greens, as Co-Amoxiclav may affect vitamin K metabolism and increase the risk of bleeding in rare cases.
• Probiotics, found in fermented foods like yogurt and kefir, can help restore healthy gut bacteria that might be affected by the antibiotic treatment.
• Avoid high-fat meals as they may delay the absorption of the medication and potentially reduce its effectiveness.
• Certain foods like beans, lentils, and whole grains can support overall digestive health and help manage potential gastrointestinal side effects.

Co-Amoxiclav 1200mg injection should be stored in a controlled environment, specifically at room temperature between 15-25°C (59-77°F), ensuring it is protected from light and moisture. It is crucial to keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. When storing, avoid placing it in the bathroom or near heat sources like radiators or stoves, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired injections responsibly; do not pour them down the drain or flush them. Consult your healthcare provider or pharmacist for guidance on proper disposal methods. Additionally, ensure that the medication is kept out of the reach of children to prevent accidental exposure or ingestion.

No

Following are the quick tips for Co-Amoxiclav 125mg/5ml Dry Syrup:

• Administer the prescribed dose as instructed by your healthcare professional.
• Ensure the correct dosage by accurately measuring the syrup with a calibrated measuring device.
• Give the syrup to your child at evenly spaced intervals to maintain consistent medication levels.
• Store the syrup in a cool, dry place, away from direct sunlight and moisture.
• Check the expiration date before each use and discard if expired.
• Do not freeze the syrup as it may affect its potency.
• Consult your doctor if your child's symptoms persist or worsen despite treatment.