Cardura (4mg) 20 Tablets

Doxazosin Mesylate, the active ingredient in the 4mg tablet, acts as a selective antagonist of post-synaptic alpha-1 adrenergic receptors in various tissues. By blocking these receptors, particularly in the vascular smooth muscle, doxazosin induces vasodilation. This mechanism primarily leads to a decrease in peripheral vascular resistance, resulting in reduced blood pressure. The relaxation of smooth muscle in the bladder neck and proximal urethra also contributes to improved urine flow and reduced symptoms of benign prostatic hyperplasia. Doxazosin's selective action on alpha-1 receptors makes it effective in managing hypertension and certain urinary symptoms without significantly affecting heart rate, a characteristic that distinguishes it from beta-blockers.

Doxazosin Mesylate 4mg

Alpha-1 adrenergic blocker

Tablet

The following are the uses of Doxazosin Mesylate 4mg Tablet:

• Used for treating high blood pressure, helping to lower and control hypertension.
• Used for managing and relieving symptoms of benign prostatic hyperplasia (BPH), reducing urinary difficulties.
• Used for improving urine flow and reducing bladder outlet obstruction.
• Used for treating and preventing urinary retention caused by an enlarged prostate.
• Used for reducing the risk of prostate surgery by alleviating symptoms.
• Used for promoting overall prostate health and reducing associated discomfort.

To be used as per doctor's advice

In the case of an overdose of Doxazosin Mesylate 4mg Tablets, symptoms may include severe dizziness, fainting, and a sudden drop in blood pressure. This can lead to lightheadedness and even loss of consciousness. It is important to recognize the signs of overdose, which may also include an irregular heartbeat and difficulty breathing. Promptly seek medical assistance if you suspect an overdose, as quick intervention can help manage and mitigate these potentially serious symptoms.

In the case of a missed dose of Doxazosin Mesylate 4mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking extra medicine to make up for a missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen. It is generally recommended to take the missed dose within a 12-hour window of the original scheduled time.

To take Doxazosin Mesylate 4mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, without crushing or chewing the tablet.

Following are the conditions or situations when Doxazosin Mesylate 4mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Doxazosin Mesylate or similar medications.
• Not suitable for patients with low blood pressure (hypotension).
• Contraindicated in patients with severe heart disease or unstable angina.
• Should not be used during pregnancy or breastfeeding.
• Avoid using this medication if you have a history of liver or kidney disease.
• Not recommended for individuals with a history of orthostatic hypotension.
• Doxazosin should not be used if you have a condition called 'aortic or mitral stenosis'.
• Do not take this medication if you are scheduled for surgery, including eye surgery for glaucoma.

The side effects of Doxazosin Mesylate 4mg Tablet may include:

• Dizziness or lightheadedness, especially when standing up or sitting up suddenly
• Fatigue or weakness
• Headaches
• Nausea and vomiting
• Skin rashes or itching
• Swelling of the face, lips, or tongue
• Chest pain or discomfort
• Difficulty breathing or shortness of breath

Following are the precautions and warnings for Doxazosin Mesylate 4mg Tablet:

• Not recommended for individuals with known allergies to Doxazosin or similar medications.
• Blood pressure should be monitored regularly during treatment, especially in patients with pre-existing low blood pressure.
• Patients with a history of kidney or liver disease should exercise caution and consult a doctor, as dosage adjustments might be necessary.
• This medication may cause dizziness or lightheadedness, especially when standing up suddenly. Patients should rise slowly to prevent falls.
• Avoid driving or operating heavy machinery until you know how this medication affects you.
• Inform your doctor if you have a history of prostate cancer or liver problems before taking this medication.
• Elderly patients may be more sensitive to the side effects; regular monitoring is advised.

Following are the drug interactions for Doxazosin Mesylate 4mg Tablet:

• Taking Doxazosin with phosphodiesterase-5 (PDE-5) inhibitors like sildenafil, tadalafil, or vardenafil can lead to increased risk of hypotension and dizziness.
• The effect of antihypertensive drugs, including beta-blockers and diuretics, may be enhanced, resulting in excessive blood pressure drop.
• Doxazosin can increase the levels of digoxin, requiring close monitoring of digoxin levels.
• It may interact with alpha-blockers, leading to increased risk of orthostatic hypotension.
• The use of Doxazosin with other alpha-1 blockers should be avoided due to the potential for additive effects and increased risk of hypotension.
• Antidepressants such as tricyclic antidepressants and SSRIs can interact, causing increased hypotensive effects.
• Antifungal medications like ketoconazole can affect Doxazosin metabolism, leading to increased side effects.

Following are the food interactions to be aware of when taking Doxazosin Mesylate 4mg Tablets:

• Grapefruit and grapefruit juice consumption should be limited or avoided. These can increase the drug's bioavailability, leading to potential blood pressure drops and increased side effects.
• Alcohol intake should be minimized as it can cause excessive dizziness and lightheadedness, especially when standing up from a sitting or lying position.
• Avoid high-sodium foods as they can counteract the antihypertensive effects of Doxazosin, making blood pressure control more challenging.
• Consuming potassium-rich foods like bananas, oranges, and spinach is advisable to maintain electrolyte balance, especially if taking diuretics alongside Doxazosin.
• Caffeine intake should be monitored as it may exacerbate certain side effects like nervousness, tremors, and palpitations.
• Doxazosin should be taken with food to enhance its absorption and reduce the risk of gastrointestinal side effects.
• No significant interactions are known with dairy products, but consuming them with medication may enhance absorption.

Doxazosin Mesylate 4mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture or air. Avoid storing them in the bathroom or kitchen, as these areas may have high humidity or temperature fluctuations that can degrade the medication. Ensure the tablets are kept away from direct sunlight, as light can affect their potency over time. Always check the expiration date on the packaging, and dispose of any expired tablets promptly. When disposing of unused or expired medication, do not flush them down the toilet or pour them into a sink. Instead, consult your local pharmacy or healthcare provider for guidance on proper disposal methods to protect the environment and prevent misuse. Keep the tablets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Doxazosin Mesylate 4mg Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Take the tablet as directed, without crushing, chewing, or breaking it.
• Ensure you stand up slowly from a sitting or lying position to prevent dizziness.
• Avoid driving or operating machinery until you know how this medication affects you.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the medication at room temperature, away from light and moisture.