Cefstar (500mg) Injection

Cefepime, a potent broad-spectrum antibiotic, exerts its bactericidal effect by disrupting bacterial cell wall synthesis. It specifically targets penicillin-binding proteins, crucial for maintaining the structural integrity of the cell wall in both Gram-positive and Gram-negative bacteria. By binding to these proteins, Cefepime inhibits the final cross-linking stage of peptidoglycan synthesis, leading to cell wall weakening and eventual cell lysis. This mechanism effectively halts bacterial growth and contributes to the eradication of the targeted pathogens.

Cefepime 500mg

Third-generation cephalosporin.

Injection

The following are the uses of Cefepime 500mg injection:

• Used for treating severe bacterial infections, particularly those caused by multi-drug resistant organisms.
• Used for managing hospital-acquired pneumonia and complicated skin infections.
• Effective against a wide range of bacteria, including Pseudomonas aeruginosa.
• Used in cases where other antibiotics have failed or are not suitable.
• Helps prevent the spread of antibiotic-resistant bacteria.
• Provides a powerful option for life-threatening infections when quick action is vital.

To be administered as per instruction of a healthcare practitioner

In the case of an overdose of Cefepime 500mg injection, it is important to recognize the potential risks and take prompt action. Symptoms may include severe nausea, vomiting, and seizures. If an overdose is suspected, seek medical assistance immediately. The healthcare provider may recommend gastric lavage or administer activated charcoal to prevent further absorption. Close monitoring of vital signs and kidney function is essential to ensure the patient's well-being and manage any potential complications.

In the case of a missed dose of Cefepime 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for the missed one, as this may increase the risk of side effects. It is recommended to contact your healthcare provider or pharmacist for specific guidance if you have missed multiple doses or are unsure about how to adjust your medication regimen. They can provide advice tailored to your individual needs.

To administer Cefepime 500mg injection, reconstitute the powder with the provided sterile water, gently swirl to dissolve, and inject the entire contents intramuscularly or intravenously as directed by your healthcare professional, ensuring proper hygiene and aseptic techniques throughout the process.

Following are the conditions/situations when Cefepime 500mg injection should not be administered:

• Should not be used in patients with a known allergy to Cefepime or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe hypersensitivity reactions to beta-lactam antibiotics.
• Not recommended for patients with a history of seizures or other neurological disorders.
• Should be avoided in patients with severe kidney impairment or those on dialysis, as dosage adjustments are necessary.
• Not suitable for the treatment of viral infections or non-bacterial infections.
• Must not be used in patients with a history of Clostridium difficile-associated diarrhea or antibiotic-associated colitis.
• Contraindicated in patients with a history of anaphylaxis or severe allergic reactions to any medication.
• Should be used with caution and avoided if possible in premature infants, especially those with hyperbilirubinemia.

The side effects of Cefepime 500mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Phlebitis (inflammation of the vein) at the injection site
• Increased liver enzymes
• Changes in blood cell counts

Following are the precautions and warnings for Cefepime 500mg Injection:

• Do not use if allergic to Cefepime or any other cephalosporin antibiotics. Severe allergic reactions may occur.
• Renal function should be monitored during treatment, especially in patients with pre-existing kidney issues. Dosage adjustments might be necessary.
• Cefepime should be used with caution in patients with a history of seizures or conditions that increase seizure risk.
• Not recommended for neonates, especially premature infants, due to the risk of brain toxicity.
• Elderly patients may be more susceptible to side effects; renal function monitoring is crucial.
• Avoid concurrent use with neuromuscular blocking agents as it may prolong the duration of neuromuscular blockade.
• Cefepime should be discontinued if signs of severe diarrhea or colitis occur, as it may indicate a serious bowel condition.
• Patients with a history of gastrointestinal diseases should be closely monitored for potential gastrointestinal side effects.

Following are the drug interactions for Cefepime 500mg injection:

• Probenecid can reduce the elimination of cefepime, potentially increasing its concentration in the body.
• Nephrotoxic drugs like aminoglycosides or vancomycin may enhance the risk of kidney damage when used with cefepime.
• Concomitant use with other nephrotoxic agents like nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics may further increase the risk of kidney-related adverse effects.
• Cefepime may decrease the effectiveness of oral contraceptives, requiring alternative contraceptive methods during and shortly after treatment.
• Drugs that affect renal function, such as diuretics or ACE inhibitors, can potentially impact the elimination of cefepime.
• It may reduce the efficacy of live attenuated vaccines (e.g., measles, mumps, rubella) when administered concurrently.
• The concurrent use of other antibiotics with a similar mechanism of action may increase the risk of antibiotic resistance.

Following are the food interactions for Cefepime 500mg injection:

• Cefepime should be administered at least one hour before or two hours after meals, as food can decrease its absorption.
• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and affect the effectiveness of Cefepime.
• Grapefruit and grapefruit juice are to be avoided as they can alter the metabolism of Cefepime, leading to increased drug levels in the body.
• Dairy products like milk, yogurt, and cheese should be consumed with caution as they may reduce the absorption of Cefepime, decreasing its effectiveness.
• Avoid high-fat meals as they can delay the absorption of Cefepime, potentially affecting the desired therapeutic effect.
• Caffeine intake should be monitored as it may interact with Cefepime, leading to increased side effects such as nervousness and insomnia.
• Maintain a balanced diet and ensure adequate hydration during the course of treatment to support overall health and aid in recovery.
• Consult your healthcare provider for specific dietary guidelines based on your medical condition and individual needs.

Cefepime 500mg injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F). Protect the injection vials from direct sunlight and moisture, ensuring they are stored in a dry place. It is crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid placing it near heat sources like radiators or ovens, as high temperatures can degrade the medication. Always check the expiration date, and do not use the injection if it is expired. For disposal, do not flush or pour the medication down the drain; instead, follow local guidelines for the safe disposal of pharmaceutical waste or consult a healthcare professional for guidance to prevent environmental contamination. Keep the injection out of the reach of children and pets to prevent accidental exposure.

No

Following are the quick tips for Cefepime 500mg injection:

• Administer the injection as directed by your healthcare professional for optimal treatment.
• Ensure the injection is prepared and administered by trained medical staff.
• Cefepime should be given slowly over 3-5 minutes to minimize discomfort.
• It is recommended to rotate injection sites to reduce the risk of tissue irritation.
• If you experience mild pain or irritation at the injection site, applying a cold compress may help.
• Always check the expiration date before using the injection.
• Store the injection as directed on the label, usually at room temperature away from direct sunlight.