CentauruS (0.5mg) 30 Tablets

Entecavir, the active ingredient in the 0.5mg tablet, primarily acts by inhibiting the hepatitis B virus (HBV) reverse transcriptase enzyme. It is a potent nucleoside analog with a high affinity for the viral reverse transcriptase. Upon entering the body, entecavir is phosphorylated to its active form, which then competes with natural substrates for incorporation into viral DNA. Once incorporated, it causes DNA chain termination, effectively halting the replication of the hepatitis B virus. This mechanism suppresses the ability of the virus to multiply and reduces the amount of HBV in the body, leading to improved liver function and decreased viral activity in patients with chronic hepatitis B.

Entecavir 0.5mg

Nucleoside reverse transcriptase inhibitor

Tablet

The following are the uses of Entecavir 0.5mg Tablet:

• Used for treating chronic hepatitis B virus (HBV) infection in adults and children.
• Used to reduce the amount of HBV in the body and improve liver health.
• Used to decrease the risk of liver cancer and cirrhosis caused by HBV.
• Used for long-term control of HBV replication and slowing down liver damage.
• Used to improve liver function and reduce symptoms in HBV-infected patients.
• Used to prevent HBV transmission from mother to child during pregnancy.
• Used as a second-line treatment option for patients not responding to other HBV medications.
• Used to manage HBV infection in patients with advanced liver disease.

In the case of an overdose of Entecavir 0.5mg Tablets, it is important to seek medical advice promptly. Symptoms of an overdose may include severe dizziness, fainting, or extreme fatigue. If you suspect an overdose, contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions and support to manage the situation effectively, ensuring the best possible outcome.

In the case of a missed dose of Entecavir 0.5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. Do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure you receive the full therapeutic benefit of the medication. It is best to maintain a consistent dosing schedule for optimal effectiveness.

To take Entecavir 0.5mg Tablet, swallow the tablet whole with a glass of water, preferably on an empty stomach, exactly as prescribed by your healthcare provider, typically once a day at the same time each day to maintain consistent blood levels.

Here are the situations when Entecavir 0.5mg Tablet should not be used:

• Must not be used in individuals with a known allergy to Entecavir or any of its components.
• Contraindicated in patients with severe kidney disease who are not on dialysis.
• Not suitable for individuals with a history of liver disease unrelated to hepatitis B.
• Should not be used during pregnancy or breastfeeding, unless the potential benefits outweigh the risks.
• Avoid use in patients with a history of decompensated liver disease.
• Not recommended for individuals with HIV who are not taking appropriate antiretroviral therapy.

The side effects of Entecavir 0.5mg Tablet may include:

• Nausea and vomiting
• Headache
• Dizziness
• Weakness or fatigue
• Insomnia (difficulty sleeping)
• Stomach pain or discomfort
• Increased liver enzymes (liver function tests may be affected)
• Respiratory issues, such as shortness of breath or coughing

Following are the precautions and warnings for Entecavir 0.5mg Tablet:

• Patients with a history of hepatitis B virus (HBV) resistance to other antiviral medications should undergo viral resistance testing before starting Entecavir therapy.
• Regular monitoring of liver function is essential during treatment, especially in patients with advanced liver disease.
• Patients with kidney impairment may require dosage adjustments, as Entecavir is primarily eliminated by the kidneys.
• Entecavir does not cure HBV infection, and it is not a cure for HIV or other viral infections.
• This medication does not prevent the transmission of HBV to others, so appropriate precautions should be taken to prevent the spread of the virus.
• Patients should not discontinue the medication without consulting their healthcare provider, as sudden stopping may lead to worsening liver disease.
• Entecavir may cause lactic acidosis, a serious medical condition. Seek immediate medical attention if you experience symptoms like unusual muscle pain, trouble breathing, stomach pain, nausea, or feeling cold, especially in your arms and legs.

Following are the drug interactions for Entecavir 0.5mg Tablet:

• Lamivudine may decrease the effectiveness of Entecavir when used together.
• Combining with tenofovir may increase the risk of kidney-related side effects.
• Entecavir may reduce the efficacy of adefovir when taken simultaneously.
• Avoid concurrent use with other nucleoside/nucleotide reverse transcriptase inhibitors to prevent potential drug interactions.
• Rifampin can decrease Entecavir blood levels, reducing its effectiveness.
• Taking with probenecid may increase Entecavir blood levels, potentially increasing the risk of side effects.
• The risk of kidney-related side effects may be elevated when combined with didanosine.

Following are the food interactions for Entecavir 0.5mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the levels of Entecavir in the blood, potentially leading to increased side effects.
• Alcohol intake should be minimized or avoided as it can affect liver function, and Entecavir is primarily metabolized in the liver.
• High-fat meals can slightly reduce the absorption of Entecavir, but this effect is not clinically significant.
• Avoid excessive caffeine intake as it can interact with Entecavir, potentially affecting its effectiveness.
• There is no need to adjust your diet specifically for Entecavir, but maintaining a balanced and healthy diet is generally recommended.
• Always ensure adequate hydration by drinking enough water throughout the day.
• Follow any dietary advice provided by your healthcare professional, especially if you have pre-existing liver conditions.

Entecavir 0.5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, heat, or moisture, as these factors can degrade the medication's quality. Always keep the tablets in their original container, tightly sealed, to prevent contamination. Regularly check the expiration date, and if the medication is no longer needed or has expired, do not flush it down the toilet or dispose of it in household trash. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment and prevent misuse. It is crucial to handle and store medications responsibly to ensure their effectiveness and safety.

Following are the quick tips for Entecavir 0.5mg Tablet:

• Consult a doctor for personalized dosage and treatment duration.
• Swallow the tablet whole with water; do not crush or chew.
• Take it at the same time each day to maintain consistent drug levels.
• Ensure regular medical tests to monitor liver function and viral load.
• Inform your doctor about all medications and supplements you take.
• Do not adjust the dose or stop without medical advice.
• Store at room temperature, away from moisture and heat.
• Keep the medication out of children's reach.