Cipesta (200mg/100ml) 100ml Vial Infusion

Ciprofloxacin 200mg Infusion works by inhibiting bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. It binds to the A subunit of DNA gyrase, preventing the relaxation of supercoiled DNA and leading to the accumulation of double-stranded DNA breaks. This disruption in DNA synthesis is bactericidal, leading to the death of susceptible bacteria. Ciprofloxacin primarily targets DNA gyrase, which is a unique enzyme in bacteria, making it a potent broad-spectrum antibiotic against a wide range of Gram-negative and Gram-positive pathogens.

Ciprofloxacin 200mg

Fluoroquinolone antibiotic.

Infusion

The following are the uses of Ciprofloxacin 200mg Infusion:

• Used for treating severe bacterial infections that require intravenous antibiotic therapy.
• Used for bacterial infections that are resistant to other antibiotics, offering a potent treatment option.
• Used for rapid control of infections in critical conditions, such as sepsis, where timely intervention is crucial.
• Used for respiratory tract infections like pneumonia, providing effective relief and recovery.
• Used for abdominal infections, including those related to the gastrointestinal system, ensuring comprehensive treatment.
• Used for skin and soft tissue infections, promoting healing and preventing further complications.
• Used for bone and joint infections, offering targeted treatment to these specific areas.
• Used for urinary tract infections that are severe and require intensive treatment.

In the case of an overdose of Ciprofloxacin 200mg Infusion, individuals may experience an increased intensity of common side effects such as nausea, vomiting, diarrhea, and dizziness. Additionally, more severe symptoms like seizures, confusion, and rapid heart rate might occur. Prompt medical intervention is necessary, and healthcare professionals should be contacted immediately for guidance and treatment options to manage the overdose effectively. Timely action can help mitigate potential complications and ensure the well-being of the affected individual.

In the case of a missed dose of Ciprofloxacin 200mg Infusion, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to adjust your dosing schedule and ensure you complete the full course of treatment.

To administer Ciprofloxacin 200mg Infusion, mix the contents of the vial with the provided diluent, swirl gently to dissolve, and administer the entire infusion solution intravenously over a period of 60 minutes, ensuring the infusion rate does not exceed 200mg per hour.

Here are the conditions or situations when Ciprofloxacin 200mg Infusion should not be used:

• Should not be used in patients with a known allergy to Ciprofloxacin or other quinolone antibiotics.
• Contraindicated in individuals with a history of tendon disorders or tendon rupture, especially those related to previous quinolone use.
• Not recommended for patients with epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Should be avoided in patients with myasthenia gravis, as it can worsen muscle weakness.
• Contraindicated in individuals with a history of hypersensitivity reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) to any quinolone.
• Not suitable for patients with severe kidney disease or those on dialysis, as dosage adjustments are necessary.
• Should not be used in children and adolescents under 18 years of age, as it may affect growing bones and joints.
• Contraindicated in pregnant and breastfeeding women due to potential risks to the fetus and infant.
• Avoid in patients with central nervous system (CNS) disorders or conditions that increase seizure risk.

The side effects of Ciprofloxacin 200mg Infusion may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Confusion
• Increased sensitivity to sunlight
• Joint or muscle pain

Following are the precautions and warnings for Ciprofloxacin 200mg Infusion:

• Patients with a known allergy to Ciprofloxacin or other quinolone antibiotics should not use this medication. Allergic reactions can be severe and require immediate medical attention.
• Dizziness, lightheadedness, and seizures are possible side effects. Patients should avoid activities that require mental alertness until they know how the medication affects them.
• Ciprofloxacin may increase the risk of tendonitis and tendon rupture, especially in patients over 60, those taking corticosteroids, and after intense physical activity. Patients should report any tendon pain or swelling immediately.
• Prolonged QT interval and other heart rhythm abnormalities can occur. Patients with a history of heart disease or risk factors should be monitored closely.
• Ciprofloxacin is metabolized by the liver and excreted by the kidneys. Patients with liver or kidney disease may require dosage adjustments.
• Ciprofloxacin can affect blood sugar levels. Diabetic patients should monitor their blood sugar regularly.
• Caution should be exercised when prescribing Ciprofloxacin to children and the elderly, as they may be more susceptible to certain side effects.

Following are the drug interactions for Ciprofloxacin 200mg Infusion:

• Theophylline levels can be increased when used with Ciprofloxacin, potentially leading to toxicity.
• Ciprofloxacin may enhance the effects of oral anti-diabetic medications, causing hypoglycemia. Close monitoring of blood glucose is advised.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can increase the risk of seizures when taken with Ciprofloxacin.
• Combining Ciprofloxacin with warfarin or other anticoagulants may elevate the risk of bleeding. Regular monitoring of coagulation parameters is recommended.
• Probenecid can reduce the elimination of Ciprofloxacin, resulting in increased levels and potential toxicity.
• The effectiveness of phenytoin may be reduced by Ciprofloxacin, requiring close monitoring of phenytoin levels.
• When used with tizanidine, there is an increased risk of elevated blood pressure and heart rate, which can be serious.

Following are the food interactions for Ciprofloxacin 200mg Infusion:

• Avoid consuming dairy products like milk, yogurt, or cheese within 2 hours before or after taking Ciprofloxacin as calcium can bind to the antibiotic, reducing its absorption.
• Limit caffeine intake from coffee, tea, or energy drinks as Ciprofloxacin may enhance the effect of caffeine, increasing the risk of side effects like nervousness and insomnia.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Ciprofloxacin, leading to increased drug levels in the body and potential side effects.
• Alcohol consumption should be minimized or avoided as it can decrease the effectiveness of Ciprofloxacin and increase the risk of liver-related side effects.
• Iron-rich foods like red meat, liver, and spinach may reduce the absorption of Ciprofloxacin. Consume these foods at least 2 hours apart from the medication.
• Vitamin and mineral supplements containing zinc, magnesium, or iron should be taken at different times to ensure optimal absorption of Ciprofloxacin.
• Avoid high-fat meals as they may delay the absorption of Ciprofloxacin, potentially affecting its effectiveness.
• Maintain a balanced diet and stay hydrated to support overall health during the course of treatment.

Ciprofloxacin 200mg Infusion should be stored in a cool, controlled environment, ideally between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the infusion from light and moisture by storing it in its original packaging until ready for use. Once opened, the infusion should be used promptly and any unused portion discarded; it should not be stored for future use. Do not freeze the medication as this may affect its potency. When disposing of unused or expired Ciprofloxacin Infusion, do not pour it down the drain or flush it into the sewage system. Instead, follow local guidelines for the safe disposal of medications, or consult a pharmacist for advice on appropriate disposal methods to minimize environmental impact.

Following are the quick tips for Ciprofloxacin 200mg Infusion:

• Administer the infusion as directed by your doctor or healthcare professional.
• Ensure the infusion is prepared and administered by trained medical staff.
• Infuse the solution slowly over the prescribed duration to minimize side effects.
• Avoid rapid or bolus injections to prevent adverse reactions.
• Monitor vital signs and patient's response during and after the infusion.
• Store the infusion at room temperature, away from direct sunlight and moisture.
• Dispose of any unused or expired medication properly.