Claforan (0.5g) 2ml, 1 Vial Injection

Cefotaxime, the active component in Cefotaxime 0.5G Injection, is a third-generation cephalosporin antibiotic. It exerts its bactericidal effect by inhibiting the synthesis of the bacterial cell wall. Cefotaxime specifically binds to and inactivates penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands during cell wall synthesis. This binding interferes with the transpeptidation and transglycosylation steps, leading to the weakening of the cell wall and ultimately causing cell lysis. Cefotaxime is particularly effective against a wide range of Gram-positive and Gram-negative bacteria, including susceptible strains of Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae.

Cefotaxime 0.5G

Cephalosporin antibiotic

Injection

The following are the uses of Cefotaxime 0.5G Injection:

• Used for treating bacterial infections, particularly those caused by susceptible bacteria.
• Used for managing severe and life-threatening infections like sepsis and meningitis.
• Used for surgical prophylaxis to prevent infections during high-risk procedures.
• Used for treating skin and soft tissue infections, including cellulitis and abscesses.
• Used for respiratory tract infections such as pneumonia and bronchitis.
• Used for bone and joint infections, ensuring effective treatment.
• Used for certain gastrointestinal infections requiring prompt intervention.
• Used for providing broad-spectrum coverage against various pathogens.

Follow these dosage instructions:

• Adult Dosage

Uncomplicated infections

In the case of an overdose of Cefotaxime 0.5G Injection, it is important to seek medical advice promptly. Overdose symptoms may include nausea, vomiting, diarrhea, and potential kidney issues. Medical professionals should be consulted immediately to manage any adverse effects and provide appropriate treatment. Prompt action can help mitigate the risks associated with an overdose of this medication.

In the case of a missed dose of Cefotaxime 0.5G Injection, it is important to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, it is recommended to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you frequently miss doses, consult your healthcare professional for advice on how to better manage your medication routine.

To administer Cefotaxime 0.5G Injection, gently swirl the vial to ensure the powder is fully dissolved, then withdraw the prescribed dose using a sterile syringe, and inject it slowly into the muscle or intravenous line as directed by your healthcare professional, ensuring proper aseptic technique.

Following are the conditions when Cefotaxime 0.5G Injection should not be used:

• Should not be used in individuals with a confirmed severe allergy to Cefotaxime or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins, as there may be cross-reactivity.
• Not recommended for individuals with a history of cholestatic jaundice/liver problems associated with Cefotaxime use.
• Should be avoided in patients with a known sensitivity to any of its components or other cephalosporins.
• Not suitable for the treatment of viral infections or non-bacterial infections.
• Contraindicated in patients with a history of severe diarrhea caused by antibiotic use, especially Clostridium difficile-associated diarrhea.
• Should be used with caution in individuals with kidney disease, and may not be suitable for those with severe kidney impairment.

The side effects of Cefotaxime 0.5G Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Allergic reactions (hives, itching, difficulty breathing)
• Vaginal itching or discharge
• Pain or inflammation at the injection site
• Mild fever
• Changes in blood test results (e.g., increased liver enzymes)

Here are the precautions and warnings for Cefotaxime 0.5G Injection:

• This medication should not be administered to individuals with a known allergy to Cefotaxime or other cephalosporin antibiotics.
• Cefotaxime should be used with caution in patients with a history of kidney or liver disease, as it may require dosage adjustments.
• It is important to complete the full course of treatment, even if symptoms improve before completion. Stopping the medication early may result in bacterial resistance or treatment failure.
• Cefotaxime may cause diarrhea, and if it becomes severe or persistent, patients should seek medical advice as it could indicate a more serious condition.
• Patients with a history of gastrointestinal diseases, especially colitis, should be closely monitored while on this medication.
• Elderly patients may be more susceptible to the side effects of Cefotaxime, and dosage adjustments might be necessary.
• Pregnant and breastfeeding women should only use Cefotaxime if clearly needed and under the supervision of a healthcare professional.

Following are the drug interactions for Cefotaxime 0.5G Injection:

• Probenecid can decrease the renal tubular secretion of cefotaxime, increasing its blood levels.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, colistin) may increase the risk of kidney damage.
• Cefotaxime may reduce the effectiveness of oral contraceptives, leading to breakthrough bleeding and potential contraceptive failure.
• It can decrease the absorption of oral vitamin K, reducing its effectiveness in treating vitamin K deficiency.
• The efficacy of live attenuated bacterial vaccines (e.g., typhoid vaccine) may be diminished when administered during cefotaxime therapy.
• May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Regular monitoring of INR is advised.
• Cefotaxime can decrease the excretion of methotrexate, potentially increasing its toxicity.

Following are the food interactions to be aware of with Cefotaxime 0.5G Injection:

• Avoid excessive alcohol consumption as it may reduce the effectiveness of Cefotaxime and increase the risk of side effects like stomach upset and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the absorption and metabolism of Cefotaxime, potentially leading to increased drug levels in the body.
• Maintain a balanced diet to support overall health and recovery during treatment with Cefotaxime.
• Avoid high-fat meals as they may delay the absorption of Cefotaxime, affecting its effectiveness.
• Ensure adequate hydration by drinking plenty of fluids, especially water, to support kidney function and help prevent potential side effects.
• Avoid caffeinated beverages in excess as they may increase the risk of caffeine-related side effects like nervousness and sleep disturbances.
• There are no specific food restrictions with Cefotaxime, but it's best to follow the advice of your healthcare provider regarding dietary choices during treatment.
• Consult your healthcare provider if you have any specific dietary concerns or conditions that may require adjustments to your diet while using Cefotaxime.

Cefotaxime 0.5G Injection should be stored in a cool, controlled environment, preferably between 2°C and 8°C (36°F and 46°F). Protect the injection vials from direct sunlight and moisture to maintain their integrity. It is crucial to store the medication in its original packaging, ensuring the seal remains intact until use. Once the vial is opened, it should be used promptly, and any unused portion should be discarded immediately. Do not use the injection if it contains particles or discoloration. Proper disposal of unused or expired medication is essential; do not throw it into the trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to minimize environmental impact. Keep the medication away from children and pets to prevent accidental exposure.

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Following are the quick tips for Cefotaxime 0.5G Injection:

• Administer the injection as directed by your doctor, typically via intramuscular or intravenous routes.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Inform your doctor if you have any allergies, especially to penicillin or cephalosporin antibiotics.
• Complete the full course of treatment, even if you feel better before completion.
• Do not stop the medication without consulting your doctor to prevent bacterial resistance.
• Store the injection as directed on the label, usually at room temperature, away from light and moisture.
• Dispose of any unused or expired medication properly, do not flush or pour into drains.