Clobederm (0.05%) 10g Cream

Clobetasol propionate, the active ingredient in Clobetasol Cream, is a potent topical corticosteroid that primarily works by reducing inflammation in the skin. It binds to cytoplasmic glucocorticoid receptors in target cells, causing them to move into the cell nucleus, where they influence gene expression. This leads to the suppression of multiple inflammatory pathways. Clobetasol inhibits the production and release of inflammatory mediators, including prostaglandins, leukotrienes, and various cytokines, which are involved in the inflammatory process. It also reduces the activity of immune cells, such as lymphocytes and macrophages, further contributing to its anti-inflammatory effects. By downregulating the expression of adhesion molecules, clobetasol cream can reduce the migration of inflammatory cells to the site of inflammation. This mechanism of action makes Clobetasol Cream effective in treating various inflammatory skin conditions.

Clobetasol

Corticosteroid

Cream

The following are the uses of Clobetasol Cream:

• Used for treating severe inflammatory skin conditions like eczema, psoriasis, and dermatitis.
• Used to reduce inflammation and relieve itching.
• Used for its potent anti-inflammatory properties to provide quick relief.
• Used in cases where other milder corticosteroids have been ineffective.
• Used to manage skin conditions that require rapid improvement.
• Used for short-term treatment due to its strength.
• Used under the guidance of a dermatologist for optimal results.
• Used to improve skin appearance and texture.

To be taken as per doctor's prescription

In the case of an overdose of Clobetasol Cream, it is important to take swift action. First, contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the severity of the overdose. Promptly remove any remaining cream from the skin and wash the affected area with mild soap and water. Monitor for symptoms such as skin irritation or changes in skin pigmentation, and seek medical care if any adverse reactions occur.

In the case of a missed dose of Clobetasol Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your application schedule to ensure the treatment's effectiveness. Remember, consistency in applying the cream is key to achieving the desired therapeutic effect.

To apply Clobetasol Cream, clean and dry the affected skin area, then gently massage a thin layer of the cream onto the skin twice a day or as directed by your healthcare provider, taking care to avoid sensitive areas like the face and eyes.

Following are the conditions/situations when Clobetasol Cream should not be used:

• Do not use if you have a known allergy to Clobetasol or any other corticosteroids.
• Avoid using on skin that is infected, broken, or has open wounds.
• Do not use on skin conditions caused by vaccination, or if you have tuberculosis or other bacterial/viral/fungal skin infections, unless directed by a doctor.
• Not suitable for long-term use or on large areas of the body, especially in children.
• Should not be used on the face, underarms, or groin area unless prescribed by a doctor.
• Do not use on skin that is thin, sensitive, or atrophic due to previous corticosteroid use.
• Avoid using on skin with acne, rosacea, or perioral dermatitis.
• Do not use if you have a skin condition called impetigo or are allergic to any of the cream's components.
• Contraindicated in individuals with a history of hypersensitivity to any of the ingredients in the formulation.

The side effects of Clobetasol Cream may include:

• Skin irritation or burning at the application site
• Itching or redness
• Thinning of the skin
• Stretch marks
• Acne or pimples
• Excessive hair growth
• Allergic reactions (such as rash, swelling, or difficulty breathing)
• Increased blood pressure (in rare cases)

Following are the precautions and warnings for Clobetasol Cream:

• Clobetasol Cream is for external use only and should not be applied near the eyes, mouth, or open wounds.
• It should not be used in individuals with a known allergy to clobetasol propionate or any other ingredients in the cream.
• Prolonged use or application to large areas of the skin should be avoided as it may increase the risk of systemic absorption and potential side effects.
• Do not use the cream under occlusive dressings or bandages as it can increase the absorption of the medication.
• Do not use Clobetasol Cream for longer than the prescribed duration, and follow the prescribed dosage to prevent side effects.
• Wash your hands thoroughly after applying the cream to avoid accidental transfer to other areas, especially the eyes.
• Consult a doctor if the treated skin condition does not improve or worsens after a few days of using Clobetasol Cream.
• Keep the cream out of reach of children and pets, and store it in a cool, dry place as directed on the packaging.

Following are the drug interactions for Clobetasol Cream:

• It may interact with other topical steroids, increasing the risk of skin atrophy and striae.
• Concomitant use with other potent corticosteroids can lead to systemic absorption, potentially causing adrenal suppression.
• Applying Clobetasol Cream along with other immunosuppressant drugs might result in increased immunosuppression.
• The cream's effect can be reduced by using other topical medications containing astringents, drying agents, or peeling agents.
• Using occlusive dressings or wraps over the treated area can increase the systemic absorption of clobetasol.
• Anticoagulants, such as warfarin, may have their effect enhanced by Clobetasol Cream, requiring close monitoring of coagulation status.
• Caution is advised when using Clobetasol Cream with other medications that affect the skin's barrier function, as this may increase the risk of systemic absorption.

Following are the food interactions for Clobetasol Cream:

• It is advisable to avoid consuming grapefruit or grapefruit juice during treatment with Clobetasol, as it may increase the drug's absorption and potentially lead to increased side effects.
• Alcoholic beverages should be used with caution, as they may cause increased skin irritation or dryness when used with Clobetasol Cream.
• Spicy foods can sometimes exacerbate skin conditions, and if you experience heightened skin sensitivity or irritation, it's best to limit their consumption.
• Dairy products, especially those high in fat, might be beneficial to include in your diet to help maintain skin hydration, which could be beneficial when using topical steroids.
• While not a direct food interaction, staying well-hydrated by drinking plenty of water can support overall skin health and potentially reduce dryness associated with steroid use.
• Avoiding excessive caffeine intake may be prudent, as it can contribute to dehydration, which could further dry out the skin, especially when using topical corticosteroids.
• Consider limiting the consumption of highly processed and sugary foods, as they may negatively impact skin health and potentially exacerbate inflammatory skin conditions.
• Include foods rich in antioxidants, such as colorful fruits and vegetables, as they can support skin healing and potentially reduce inflammation.

Clobetasol Cream should be stored in a cool, dry location, preferably at room temperature, away from direct sunlight and moisture. It is crucial to maintain the cream's integrity by ensuring the container is tightly sealed, preventing any contamination. Avoid exposing the cream to extreme temperatures, such as those found in bathrooms or near heat sources like stoves or radiators, as this can impact its effectiveness. Always check the expiration date, and dispose of the cream responsibly by consulting a pharmacist or healthcare professional for guidance on proper disposal methods. Do not flush or pour it down the drain. Keep the cream securely stored, out of the reach of children, to prevent accidental contact or ingestion.

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Following are the quick tips for Clobetasol Cream:

• Apply a thin layer to the affected skin areas as directed by your doctor.
• Wash your hands before and after applying the cream to avoid unnecessary contact.
• Gently rub the cream into the skin until it is fully absorbed.
• Use the cream only on the skin and avoid sensitive areas like eyes, mouth, and open wounds.
• Do not cover the treated area with bandages or tight clothing to allow the skin to breathe.
• If you forget a dose, apply it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor if your condition doesn't improve or worsens after using the cream.