Clozox-H (10/10mg) 10g Cream

Clotrimazole, a key component of the cream, is an antifungal agent that specifically targets and eradicates a wide range of fungi. It achieves this by disrupting the fungal cell membrane, inhibiting the synthesis of ergosterol, a crucial component for maintaining the integrity of fungal cell walls. This disruption leads to the impairment of the fungal cell's structure and function, ultimately resulting in its demise. Hydrocortisone, the other active ingredient, is a potent corticosteroid with anti-inflammatory properties. It functions by binding to corticosteroid receptors within cells, leading to a reduction in the production of various inflammatory mediators. This action helps alleviate inflammation, redness, and itching associated with certain skin conditions.

Clotrimazole, Hydrocortisone

Antifungal, corticosteroid cream.

Cream

The following are the uses of Clotrimazole, Hydrocortisone Cream:

• Used for treating athlete's foot, jock itch, and ringworm.
• Used to relieve itching, redness, and swelling associated with these fungal skin infections.
• Used for reducing inflammation and discomfort caused by certain skin conditions.
• Used to manage skin irritation and rashes in specific areas.
• Used for quick relief from symptoms, providing comfort to affected areas.
• Used for both adults and children, offering effective treatment.
• Used as a short-term solution until the infection clears.

Apply this cream to the affected area twice daily for 2-4 weeks.

In the case of an overdose of Clotrimazole, Hydrocortisone Cream, symptoms may include a burning or itching sensation at the application site, redness, and possible skin irritation. Prolonged or excessive use can lead to skin thinning, stretch marks, or changes in skin pigmentation. If ingested, it may cause nausea, vomiting, or stomach discomfort. It is advisable to contact a healthcare professional for guidance and to provide information about the extent of the overdose.

In the case of a missed dose of Clotrimazole, Hydrocortisone Cream, it is important to apply the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose. If you miss multiple doses, contact your healthcare provider for guidance, especially if you are treating a severe infection. They will advise you on how to adjust your dosing schedule to ensure the medication's effectiveness.

To use Clotrimazole, Hydrocortisone Cream, gently clean and dry the affected skin area, then apply a thin layer of the cream to the skin, usually twice a day or as directed by your healthcare provider, covering the entire affected area and rubbing it in gently.

Here are the conditions and situations when Clotrimazole, Hydrocortisone Cream should not be used:

• Avoid using if you have a known allergy or sensitivity to clotrimazole, hydrocortisone, or any other ingredients in the cream.
• Do not use on children under the age of 12 without medical supervision.
• Not suitable for individuals with certain skin conditions such as rosacea, acne, perioral dermatitis, or skin infections like tuberculosis, herpes, or chickenpox.
• Do not apply to open wounds, burns, or broken skin.
• Avoid using on skin areas with severe inflammation or skin atrophy.
• Not recommended for long-term use, especially on large areas of the body.
• Avoid using on the face, underarms, or groin unless directed by a healthcare professional.
• Do not use if you are taking other medications that may interact with hydrocortisone, such as anticoagulants or other corticosteroids.
• Should not be used to treat diaper rash in infants.
• Contraindicated for individuals with a history of hypersensitivity or allergic reactions to similar medications.

The side effects of Clotrimazole, Hydrocortisone Cream may include:

• Skin irritation or burning at the application site
• Itching or redness
• Dryness or peeling of the skin
• Thinning of the skin
• Acne or pimples
• Stretch marks
• Increased hair growth in the treated area
• Allergic reactions (such as rash, hives, or difficulty breathing)

Following are the precautions and warnings:

• Clotrimazole, Hydrocortisone Cream should not be used for extended periods or on large areas of the body without medical supervision. Prolonged use may lead to thinning of the skin and increased risk of side effects.
• Avoid applying the cream to the eyes, mouth, or other sensitive areas unless directed by a healthcare professional.
• Do not use this medication if you are allergic to any of its ingredients, including clotrimazole or hydrocortisone.
• This cream is for external use only. Do not swallow or ingest it.
• Wash your hands before and after applying the cream to avoid spreading the infection to other areas or to other people.
• Do not use the cream for conditions other than those prescribed by your doctor.
• If you are pregnant or breastfeeding, consult your healthcare provider before using this medication, as the effects on the fetus or infant are not fully established.
• Stop using the cream and seek medical attention if you experience signs of an allergic reaction, such as severe itching, rash, or difficulty breathing.

Following are the drug interactions for Clotrimazole, Hydrocortisone Cream:

• It may interact with other topical medications, especially those containing corticosteroids, increasing the risk of skin thinning and other side effects.
• Concomitant use with other antifungal medications, such as oral azoles, can lead to increased antifungal effects and potential toxicity.
• Hydrocortisone may interact with systemic corticosteroids, altering their effects and potentially leading to adrenal suppression.
• Using Clotrimazole with other azole antifungals can increase the risk of liver enzyme elevations.
• The cream may reduce the effectiveness of live vaccines when applied to large areas of the skin, potentially impacting the immune response.
• Applying other skin products containing alcohol or harsh chemicals may cause irritation or alter the effectiveness of the cream.
• Caution is advised when using with medications that affect the immune system, as the cream's effect on the skin's immune response may be significant.

Following are the food interactions for Clotrimazole, Hydrocortisone Cream:

• Alcohol-based products like hand sanitizers, certain wet wipes, or other skin products can cause irritation or dryness when used with this cream, so it's best to avoid them.
• Avoid consuming grapefruit or grapefruit juice as it may affect the effectiveness of the clotrimazole component.
• Caffeine-containing beverages such as coffee, tea, or energy drinks may increase the risk of side effects when used with hydrocortisone.
• Dairy products like milk, cheese, or yogurt may interact with clotrimazole, reducing its absorption.
• Spicy foods can potentially irritate the skin, especially if the treated area is exposed or sensitive.
• Avoid sugary foods and beverages as they can promote the growth of yeast and fungi, reducing the effectiveness of clotrimazole.
• Vitamin C-rich foods like citrus fruits and broccoli may interfere with the absorption of hydrocortisone.
• Foods high in fat and oil can affect the absorption of both clotrimazole and hydrocortisone, potentially reducing their effectiveness.

Clotrimazole, Hydrocortisone Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the cream in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid storing it in areas with temperature fluctuations, such as bathrooms or near heat sources, as this can impact its effectiveness. Always check the expiration date, and if the cream is past its expiry, do not use it and dispose of it carefully. For proper disposal, consult a pharmacist or healthcare professional for guidance, and never flush it down the toilet or pour it into drainage systems. It is crucial to keep the cream out of children's reach to prevent accidental contact or ingestion.

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Following are the quick tips for Clotrimazole, Hydrocortisone Cream:

• Clean and dry the affected area before applying the cream.
• Apply a thin layer of cream to the affected skin, ensuring complete coverage.
• Gently rub the cream into the skin until it is absorbed.
• Wash your hands after applying the cream to avoid accidental contact with other body parts.
• Use the cream as directed, typically twice a day, for the prescribed duration.
• Avoid covering the treated area with tight-fitting clothing or bandages to allow the skin to breathe.
• Do not use the cream for longer than recommended; consult your doctor if symptoms persist or worsen.