Coversam (8/5mg) 10 Tablets

Amlodipine 5mg and Perindopril 8mg work synergistically in this tablet to effectively manage hypertension. Amlodipine, a calcium channel blocker, acts by inhibiting the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. On the other hand, Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and promotes the breakdown of bradykinin, a vasodilator. This dual mechanism of action effectively lowers blood pressure by relaxing blood vessels and reducing the workload on the heart.

Amlodipine 5mg, Perindopril 8mg

Calcium channel blocker, ACE inhibitor.

Oral

The following are the uses of Amlodipine 5mg, Perindopril 8mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to relax and widen blood vessels, improving blood flow
• Used for patients with heart-related chest pain (angina)
• Used to reduce the risk of future heart attacks or strokes
• Used to manage symptoms of Raynaud's phenomenon
• Used to lower blood pressure and ease the heart's workload
• Used to improve exercise capacity in heart failure patients
• Used to help prevent cardiovascular events in at-risk individuals

To be used as per doctor's prescription

In the case of an overdose of Amlodipine 5mg and Perindopril 8mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and an abnormal heart rate. Severe cases can lead to a significant drop in blood pressure, causing fainting or even shock. It is crucial to seek medical assistance promptly, as healthcare professionals may recommend inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Timely intervention is vital to ensure the best possible outcome and minimize potential complications.

In the case of a missed dose of Amlodipine 5mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Perindopril 8mg, if you miss a dose, take it as soon as you remember, unless it's close to the time for your next dose. In this case, skip the missed dose and continue with your regular dosing routine. It's important to note that you should not double the dose to make up for a missed one without consulting your healthcare provider first.

To take the Amlodipine 5mg and Perindopril 8mg tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Amlodipine 5mg and Perindopril 8mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Amlodipine, Perindopril, or other related medications.
• Contraindicated in patients with a history of angioedema (swelling under the skin) associated with previous use of ACE inhibitors.
• Not recommended for individuals with severe liver disease or impaired liver function.
• Should not be used in patients with aortic valve stenosis (narrowing of the aortic valve in the heart).
• Contraindicated in pregnant women, especially during the second and third trimesters.
• Not suitable for individuals with hypotension (very low blood pressure).
• Should be avoided in patients with severe renal impairment or those on dialysis.
• Not recommended for individuals with hypertrophic cardiomyopathy (a heart muscle disease).
• Should not be used in patients with unstable or uncontrolled heart failure.
• Contraindicated in patients with a history of hereditary angioedema.

The side effects of Amlodipine 5mg, Perindopril 8mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea or stomach pain
• Swelling of ankles and feet (peripheral edema)
• Skin rash or itching
• Rapid or irregular heartbeat
• Muscle cramps

Following are the precautions and warnings for Amlodipine 5mg, Perindopril 8mg Tablet:

• Not recommended for individuals with a known allergy to amlodipine, perindopril, or any other ACE inhibitors.
• Patients with a history of liver or kidney problems should use this medication with caution, as it may require dosage adjustments.
• Elderly patients may be more sensitive to the effects of this medication, especially during the initial stages of treatment.
• Patients with a history of heart disease, aortic stenosis, or hypertrophic cardiomyopathy should be closely monitored while taking this medication.
• Avoid activities that require mental alertness, as this medication may cause dizziness or lightheadedness.
• Inform your doctor if you have diabetes, as this medication may affect blood sugar levels.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.

Following are the drug interactions for Amlodipine 5mg, Perindopril 8mg Tablet:

• When taken with other blood pressure medications, such as beta-blockers or ACE inhibitors, the effects on blood pressure may be additive, requiring close monitoring.
• Grapefruit juice can increase the blood levels of Amlodipine, potentially leading to increased side effects.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effects of Perindopril.
• The use of potassium-sparing diuretics or potassium supplements with Perindopril may lead to hyperkalemia.
• Drugs affecting the Renin-Angiotensin-Aldosterone System (RAAS), such as angiotensin receptor blockers (ARBs), may increase the risk of renal impairment when used with Perindopril.
• Perindopril may enhance the hypoglycemic effect of insulin or oral antidiabetic agents.
• The combination with lithium may increase the risk of lithium toxicity.
• Amlodipine may have its metabolism affected by strong CYP3A4 inhibitors, leading to increased blood levels.

Following are the food interactions for Amlodipine 5mg, Perindopril 8mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of Amlodipine, potentially leading to an increased risk of side effects.
• Avoid excessive alcohol consumption as it may lower blood pressure further and increase the risk of side effects like dizziness and lightheadedness.
• Avoid high-sodium foods as they can reduce the effectiveness of Perindopril in controlling blood pressure.
• Limit the intake of potassium-rich foods like bananas, oranges, and spinach, as Perindopril can increase potassium levels in the blood.
• Avoid or limit the use of salt substitutes or potassium supplements unless directed by a doctor, as this medication can also affect potassium levels.
• Be cautious with licorice consumption, as it may reduce the effectiveness of Amlodipine.
• Inform your healthcare provider about your diet, especially if it includes large amounts of dairy products, as this can impact the absorption of Perindopril.
• Always follow your healthcare provider's dietary recommendations to ensure the medication's effectiveness and minimize potential interactions.

Amlodipine 5mg, Perindopril 8mg tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. The original container should be used to keep the tablets, ensuring a tight seal to maintain their integrity. It is crucial to avoid storing them in areas with high heat or humidity, such as kitchens or bathrooms, as this can degrade the medication. Always check the expiration date, and for proper disposal, consult your pharmacist or healthcare professional to ensure safe and environmentally friendly practices. Keep the tablets out of children's reach to prevent accidental consumption, and never dispose of them in sinks or toilets, as this can cause environmental harm.

No

Following are the quick tips for Amlodipine 5mg and Perindopril 8mg Tablet:

• Take the medication as directed by your doctor, usually once daily.
• Swallow the tablet whole with a full glass of water.
• Consume the tablet at the same time each day for best results.
• Avoid crushing or chewing the tablet.
• Do not stop taking the medication without consulting your doctor.
• Store in a cool, dry place away from sunlight.
• Inform your doctor about all medications you are currently taking.