Dapa-Met (5/850mg) 14 Tablets

Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, works by increasing the removal and decreasing the absorption of glucose in the bloodstream. Metformin hydrochloride, a biguanide, increases the body's sensitivity to insulin, and also decreases the amount of sugar made by the liver. Both of these medicines work simultaneously to help control blood sugar levels in those with type 2 diabetes, reducing the risk of complications related to the disease. While these drugs can assist with managing blood sugar levels, they should be taken only as prescribed by a medical professional.

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SGLT2 Inhibitor, Biguanides

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Improving blood sugar control in adults with type 2 diabetes who are intolerant to Metformin alone
• Used as part of basal insulin therapy in adults with type 1 or type 2 diabetes
• Helps reduce the risk of cardiovascular death in adult patients with diabetes and known heart disease

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take as directed by your doctor.
• Do not take more or less than the prescribed dosage.
• Keep medication out of reach of children.
• Avoid alcohol and grapefruit juice while on this medication.

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An overdose of Dapagliflozin and Metformin Hydrochloride can be a serious matter and requires immediate medical attention. If you suspect someone has experienced an overdose of these medications, it is crucial to seek professional medical assistance as soon as possible. The treatment for an overdose may include various interventions depending on the individual's circumstances. Firstly, procedures like emesis (inducing vomiting) and gastric lavage (stomach pumping) may be used to remove any remaining medication from the stomach, reducing the risk of further absorption. Additionally, activated charcoal may be administered to bind with the drugs in the digestive system, preventing their absorption. General supportive care is also important, which may include monitoring vital signs, providing oxygen supplementation, and managing any complications to ensure the patient's comfort and safety. Due to the potential for hypoglycemia (low blood sugar) and subsequent hypotension (low blood pressure) and electrolyte imbalances, doctors may prescribe intravenous fluids and electrolytes to correct these abnormalities. In severe cases, when blood sugar levels drop significantly, a glucagon injection may be given to raise them. Oxygen therapy may also be provided if there are concerns about respiratory symptoms or low oxygen levels in the blood. Due to Metformin's excretion through the kidneys, kidney function monitoring is crucial in cases of overdose. If the overdose is severe, intravenous (IV) glucose solutions may be administered to rapidly raise the blood sugar level. Remember, it is vital to contact your healthcare provider or local emergency services immediately if you suspect an overdose of Dapagliflozin and Metformin Hydrochloride. The timely and appropriate treatment could make a real difference in managing the situation and preventing further health complications.

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If you missed a dose of your medication, it is important to take it as soon as you remember. However, if you are close to your next scheduled dose, it is best to skip the missed one and return to your regular schedule. It is crucial to maintain the routine of your medication schedule, as missing a dose can affect the efficacy of the treatment. To ensure you make the right decision, it is recommended to contact your physician or pharmacist for guidance if you are uncertain about whether to take a missed dose. Missing a dose can lead to complications, so it is important to take your medication as directed and seek guidance if needed.

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Dapagliflozin 5mg should be taken orally, usually once daily, as directed by a medical professional. It is recommended to take it with or without food. However, it is important to take Metformin Hydrochloride 850mg orally, usually twice a day alongside meals. The usual dose starts at 500 mg twice a day, but the prescription may vary depending on individual needs. It is essential to follow the advice of a medical professional and carefully read the medication leaflet to better understand the personalized directions and potential risks and benefits.

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Discerning instances where this medication may not be appropriate:

• If you are taking other medications for diabetes, as they can cause low blood sugar levels and combining them with Dapagliflozin can amplify this effect.
• In patients with moderate to severe renal impairment to avoid side effects caused by drug accumulation.
• Kidney damage or problems 
• Metformin can build up in the body and cause toxicity because it is excreted by the kidneys.
• Lactic acidosis is a known side effect of Metformin.

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Unraveling the side effects lurking behind this medications are as follows:

• Hypoglycemia (low blood sugar)
• Upper respiratory tract infection
• Inflammation of the throat (pharyngitis)
• Nasal congestion
• Back pain
• Diarrhea
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal discomfort
• Loss of appetite
• Weakness
• Headache
• Fatigue
• Irritability
• Mood swings

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Patients should be aware of the following precautions and warnings when considering treatment:

• Do not use in patients with type 1 diabetes mellitus or for diabetic ketoacidosis.
• Risk of lactic acidosis, especially in diabetic patients with significant renal failure or other risk factors such as poorly controlled diabetes, ketosis, prolonged fasting, excessive alcohol intake, hepatic insufficiency, dehydration, and acute conditions associated with hypoxia or impaired renal function.
• Caution with concomitant use of drugs that can impair renal function, such as antihypertensives, diuretics, and NSAIDs.
• Discontinue if metabolic acidosis is suspected or if dehydration, severe infection, or hypoperfusion occurs.
• Promptly discontinue in cases of cardiovascular collapse (e.g., shock, acute heart failure, acute myocardial infarction) or other conditions characterized by hypoxemia.
• Temporarily discontinue therapy before or during intravascular contrast studies with iodinated materials and withhold for 48 hours, reinstituting only after renal function has been re-evaluated.
• Suspend therapy for any surgical procedure, except minor ones not associated with restricted intake of food and fluids.
• Caution with excessive alcohol intake.
• Be aware of predisposing factors to ketoacidosis, such as low β-cell function reserve due to pancreatic disorders, insulin dose reduction, reduced caloric intake, or increased insulin requirements due to infections, illness, surgery, or alcohol abuse.
• Evaluate serum electrolytes, ketones, blood glucose, blood pH, lactate pyruvate, and metformin levels in patients with type 2 diabetes mellitus.
• Temporary interruption may be necessary for patients who develop volume depletion.
• Caution with concomitant use of insulin and insulin secretagogues like sulfonylureas, as hypoglycemia is especially risky in elderly, debilitated, malnourished patients, or those with adrenal or pituitary insufficiency or alcohol intoxication.
• Discontinue if Fournier's gangrene is suspected.
• Avoid in patients with persistently low eGFR (<45 mL/min/1.73 m²), severe renal impairment (eGFR <30 mL/min/1.73 m²), or end-stage renal disease (ESRD). Assess renal function before starting therapy.
• Avoid in patients with clinical or laboratory evidence of hepatic disease.
• Not to be used during pregnancy (second and third trimesters) or lactation.
• Use cautiously in children and elderly patients.

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Drug interactions with dapagliflozin + metformin include:

• Diuretics (e.g., furosemide) (may increase the risk of dehydration and hypotension)
• Insulin (e.g., glargine) (may increase the risk of hypoglycemia- monitor blood glucose levels closely)
• Other oral hypoglycemic agents (e.g., sulfonylureas) (may have additive effects on blood glucose control)
• Renin-angiotensin-aldosterone system inhibitors (e.g., lisinopril) (may increase the risk of hypotension and renal impairment)
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) (may impact renal function and increase the risk of dehydration)
• CYP3A4 inhibitors (e.g., ketoconazole) (no significant interaction with dapagliflozin, but monitor for potential changes in efficacy)
• CYP3A4 inducers (e.g., rifampin) (may affect the metabolism and efficacy of dapagliflozin)
• Contrast agents (e.g., iodinated contrast media) (may increase the risk of acute kidney injury- ensure adequate hydration)
• Metformin-related interactions (e.g., alcohol) (may increase the risk of lactic acidosis)

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Dapagliflozin should be stored at room temperature, ideally between 68°F to 77°F (20°C to 25°C). This medication should be kept in a dry place and away from heat, moisture, and light. It is essential to keep it out of the reach of children and pets and not store it in the bathroom due to high humidity. Instead, choose a cool, dry location, such as a shelf in a hallway or closet. If you have any questions about the storage of dapagliflozin, consulting with your doctor or pharmacist is advisable.Metformin hydrochloride should also be stored at room temperature, between 59°F to 86°F (15°C to 30°C). This medication should be kept in a dry place and away from moisture and extreme temperatures. Just like dapagliflozin, it should be kept out of the reach of children and pets, and not stored in the bathroom or near a sink. If you notice any changes in the medication's appearance, such as a change in color or consistency, or if the expiration date has passed, it is important to notify your doctor or pharmacist. They may advise you to dispose of it properly. Following the specific storage instructions provided by your doctor or pharmacist is crucial, as proper storage helps maintain the potency and safety of the medications. If you have any further questions or concerns about storing dapagliflozin or metformin hydrochloride, it is recommended to reach out to your healthcare provider for guidance.

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