Daplozmet (5/850mg) 14 Tablets

Dapagliflozin and Metformin combination therapy works through distinct mechanisms to manage blood sugar levels. Dapagliflozin, an SGLT2 inhibitor, blocks the reabsorption of glucose in the kidneys, leading to increased glucose excretion in urine and reduced blood sugar levels. Metformin, on the other hand, primarily acts by suppressing glucose production in the liver, enhancing insulin sensitivity in peripheral tissues, and reducing intestinal absorption of glucose, thereby decreasing overall blood glucose levels. Together, these mechanisms synergistically contribute to improved glycemic control.

Dapagliflozin 5mg, Metformin 850mg

SGLT2 inhibitor, Biguanide.

Tablet

The following are the uses of Dapagliflozin 5mg, Metformin 850mg Tablet:

• Used for treating type 2 diabetes by lowering blood sugar levels.
• Used to improve glycemic control when metformin alone is not sufficient.
• Used to reduce the risk of cardiovascular events such as heart attack or stroke in diabetic patients.
• Used to aid in weight loss and improve blood sugar control.
• Used to reduce insulin resistance and improve insulin sensitivity.
• Used to delay the progression of diabetes and prevent long-term complications.
• Used to lower the risk of kidney disease progression in diabetic patients with chronic kidney disease.
• Used as part of a comprehensive diabetes management plan including diet and exercise.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as prescribed by the doctor, through mouth with a glass of water.
• Take the tablet at a scheduled day regularly to get the most benefit.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Dapagliflozin 5mg and Metformin 850mg tablets, individuals may experience symptoms such as dizziness, nausea, and excessive urination. Prompt medical intervention is necessary, as the severity of symptoms can vary. Patients should contact their healthcare provider or seek emergency medical care, where treatment may include monitoring vital signs, administering intravenous fluids, and providing supportive care to manage symptoms effectively.

In the case of a missed dose of Dapagliflozin 5mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Metformin 850mg Tablet, if you miss a dose, take it as soon as you remember, but if it's closer to your next dose, skip the missed dose and resume your regular dosing pattern. It's generally recommended to take the missed dose as soon as possible, but avoid taking double doses to catch up. Consult your healthcare provider if you frequently miss doses for further guidance.

To take Dapagliflozin 5mg and Metformin 850mg tablets, swallow one tablet with a full glass of water, preferably during mealtime, exactly as prescribed by your healthcare provider, ensuring you do not exceed the recommended dosage.

Following are the conditions or situations when Dapagliflozin 5mg and Metformin 850mg Tablet should not be used:

• Should not be used in patients with a known allergy to either Dapagliflozin or Metformin, or any other ingredients in the tablet.
• Not suitable for patients with severe kidney problems or those with diabetic ketoacidosis.
• Contraindicated in patients with a history of a serious hypersensitivity reaction to Dapagliflozin, such as anaphylaxis or angioedema.
• Should not be used in individuals with a history of a serious condition called lactic acidosis, whether caused by Metformin or not.
• Not recommended for patients with a history of a recent heart attack or unstable heart failure.
• Should not be used in patients with moderate to severe liver disease.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with a history of bladder cancer or currently undergoing bladder surgery.

The side effects of Dapagliflozin 5mg, Metformin 850mg Tablet may include:

• Increased urination
• Nausea and vomiting
• Diarrhea
• Stomach pain or discomfort
• Low blood sugar (hypoglycemia)
• Dizziness or lightheadedness
• Yeast infections or urinary tract infections
• Skin rash or itching

Following are the precautions and warnings for Dapagliflozin 5mg, Metformin 850mg Tablet:

• Patients with type 1 diabetes should not use this medication, as it is intended for type 2 diabetes.
• Kidney function should be monitored regularly, and the medication should be used with caution in patients with kidney disease.
• It may cause dehydration and volume depletion; individuals should be advised to maintain adequate fluid intake.
• Patients with a history of bladder cancer or other urogenital malignancies should be monitored closely while on this medication.
• Elderly patients may be more susceptible to the side effects; dosage adjustments might be necessary.
• Discontinue the medication if a patient experiences ketoacidosis and initiate appropriate treatment.
• This medication can cause a rare but serious condition called lactic acidosis; patients should be educated about the symptoms and seek immediate medical attention if experienced.

Following are the drug interactions for Dapagliflozin 5mg, Metformin 850mg Tablet:

• Dapagliflozin may interact with diuretics, leading to increased diuresis and potential electrolyte imbalances.
• Metformin can interact with contrast agents, increasing the risk of lactic acidosis. Temporary discontinuation of the drug is advised before certain radiologic procedures.
• Concomitant use of Dapagliflozin with insulin or insulin secretagogues may increase the risk of hypoglycemia.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the effectiveness of Dapagliflozin and may increase the risk of kidney-related adverse effects.
• The use of Metformin with certain drugs like corticosteroids, beta-agonists, and diuretics may increase the risk of hyperglycemia.
• Dapagliflozin may enhance the effects of blood pressure medications, potentially leading to hypotension.
• Drugs that affect kidney function, such as ACE inhibitors or ARBs, may require dosage adjustments when used with Dapagliflozin.

Following are the food interactions for Dapagliflozin 5mg and Metformin 850mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a rare but serious side effect of Metformin.
• Dapagliflozin may cause dehydration, so ensure adequate fluid intake, especially when consuming diuretic foods like watermelon, cucumber, and herbal teas.
• Avoid high-potassium foods like bananas, oranges, and spinach if you have kidney issues, as Dapagliflozin can increase potassium levels.
• Limit sugary and high-carbohydrate foods as they can impact blood sugar control, affecting the medication's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect liver enzymes and alter the medication's metabolism.
• No significant interactions with dairy, meat, or most vegetables, but a balanced diet is essential for overall health.
• Always discuss dietary concerns with your healthcare provider to ensure safe and effective medication use.

Dapagliflozin 5mg, Metformin 850mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures, including heat sources like radiators or stoves, as this can impact their effectiveness. Regularly check the expiration date, and properly dispose of any unused or expired tablets by consulting a pharmacist or healthcare professional for guidance. It is crucial to keep the medication away from children to prevent accidental consumption.

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Following are the quick tips for Dapagliflozin 5mg and Metformin 850mg Tablet:

• Always take the medication as directed by your doctor, do not adjust the dosage without medical advice.
• Take Dapagliflozin with or without food, but take Metformin with meals to reduce stomach upset.
• Swallow the tablets whole, do not crush or chew them.
• Maintain a consistent medication schedule for better control of blood sugar levels.
• Avoid alcohol consumption as it may increase the risk of side effects.
• Regularly monitor your blood sugar levels and inform your doctor of any significant changes.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.