Deltacortril EC (5mg) 100 Tablets

Prednisolone is a corticosteroid medication used to reduce inflammation and suppress the immune system. It works by mimicking the effects of cortisol, a hormone produced by the adrenal glands. Prednisolone binds to glucocorticoid receptors inside cells, which then enter the nucleus and influence gene expression. This results in a decrease in the production of inflammatory substances like prostaglandins and leukotrienes. Additionally, prednisolone helps regulate immune responses by reducing the activity of immune cells, thus alleviating symptoms of various inflammatory and autoimmune conditions. It is commonly used to treat conditions such as asthma, allergies, and rheumatoid arthritis.

Corticosteroid

This medication is used to treat:

• Inflammation
• Allergic Reactions
• Autoimmune Disorders
• Corticosteroid Replacement

Prednisolone dosage recommendations are:

• Nephrotic syndrome - Child - Standard regimen - 60 mg/m² daily in 3 divided doses for 4 weeks, followed by 40 mg/m² on alternate days for 4 weeks.
• Acute exacerbations in multiple sclerosis - Adult - 200 mg daily for 1 week, followed by 80 mg every other day for 1 month.
• Anti-inflammatory or immunosuppressive - Adult - Initial range - 5-60 mg daily, may be divided daily doses or a single morning dose, or alternate days. Use the lowest effective dose for the shortest period. Child - 0.14-2 mg/kg daily in 3 or 4 divided doses. Use the lowest effective dose for the shortest duration.

Too many tablets can make you unwell. Contact your doctor or nearest hospital accident and emergency department.

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not double up.

The tablets should only be taken by mouth and can be swallowed with water. They can be taken before or after a meal.

Do not take Prednisolone Enteric coated if you:

• Are suffering from an untreated widespread (systemic) infection
• Are allergic to prednisolone or any of the other ingredients
• Are suffering from a herpes infection of the eye

The side effects of Prednisolone tablets are as follows:

• Gastrointestinal discomfort
• Weight gain
• Mood changes
• Increased appetite
• Insomnia

Patients should take the following precautions and warnings into account before using this medication:

• Individuals with a personal or family history of severe affective disorders (e.g., steroid psychosis, depressive or manic-depressive illness) need special caution.
• Patients with a history of tuberculosis (TB), latent TB, or tuberculin reactivity, as well as those with known or suspected Strongyloides infection, should be cautious.
• Diabetes mellitus patients or those with a family history of diabetes should be monitored.
• Those with gastrointestinal diseases (e.g., diverticulitis, ulcerative colitis, active or latent peptic ulcer, recent intestinal anastomoses, abscesses, or pyogenic infections) should be cautious.
• Patients with glaucoma or a family history of glaucoma, cataracts, or a history of ocular herpes simplex need special consideration.
• Hypertension, congestive heart failure (CHF), or a recent myocardial infarction (MI) with a risk of rupture are significant risk factors to consider.
• Existing or potential osteoporosis (e.g., postmenopausal women) or seizure disorders require caution.
• Those with systemic sclerosis, Cushing’s disease, steroid myopathy, myasthenia gravis, thromboembolic disorders, Duchenne’s muscular dystrophy, or thyroid disease should be closely monitored.
• Patients under unusual stress (e.g., surgery, trauma, intercurrent illness) need to take special care.
• Exposure to individuals with chickenpox or measles should be avoided.
• Avoid abrupt withdrawal during long-term therapy, as it may mask the signs of infection.
• Use in active TB cases should be limited to fulminating or disseminated TB.
• Patients with renal or hepatic impairment, including cirrhosis, need to be closely monitored.
• Caution is needed for children and elderly individuals.
• Special attention is required for pregnancy and lactation.

Drug interactions with prednisolone include:

• Anticoagulants (e.g., warfarin) (may enhance the effect of anticoagulants)
• NSAIDs (e.g., ibuprofen) (increased risk of gastrointestinal bleeding or ulceration)
• Antidiabetic medications (e.g., insulin, metformin) (may increase blood glucose levels)
• Live vaccines (e.g., MMR) (prednisolone may reduce vaccine efficacy)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase prednisolone levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease prednisolone levels)
• Antihypertensives (e.g., ACE inhibitors) (prednisolone may cause fluid retention and hypertension)

Store at room temperature in a tightly sealed container. Dispose of unused or expired medication by returning it to a pharmacy for safe disposal.