Dexoflox (0.1/0.3%) 5ml Eye Drops

Dexamethasone in the Ofloxacin-Dexamethasone combination eye drop acts as a potent anti-inflammatory agent. It belongs to the corticosteroid class of drugs and exerts its effects by binding to cytoplasmic glucocorticoid receptors. Upon binding, the activated receptor-drug complex translocates to the nucleus, where it regulates gene expression by inducing the synthesis of anti-inflammatory proteins and suppressing the expression of pro-inflammatory mediators. This results in the reduction of inflammation, vasodilation, leukocyte infiltration, and edema associated with various ocular conditions.

Dexamethasone, Ofloxacin

Corticosteroid, Antibiotic.

drop

The following are the uses of Dexamethasone, Ofloxacin Drop:

• Used for treating eye infections, such as conjunctivitis and corneal ulcers.
• Used to reduce inflammation and swelling in the eye after surgery or injury.
• Used to manage eye allergies, providing quick relief from itching and redness.
• Used in the treatment of uveitis, an inflammation of the middle layer of the eye.
• Effective in preventing and treating eye infections in patients with low immune systems.
• Helps alleviate eye discomfort and irritation caused by environmental factors like smoke or dust.
• Can be used post-operatively to prevent infection and promote healing in various eye surgeries.
• Provides short-term relief from eye dryness and irritation due to its anti-inflammatory properties.

To be taken as per doctor's prescription

In the case of an overdose of Dexamethasone, symptoms may include increased heart rate, fluid retention, and mood changes. Medical attention should be sought for proper management. For Ofloxacin Drops, an overdose may lead to nausea, dizziness, and headache. Promptly consult a healthcare professional for guidance and appropriate treatment options. It is crucial to act swiftly and seek professional advice to address any potential health risks associated with these overdoses.

In the case of a missed dose of Dexamethasone, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss a dose of Ofloxacin eye drops, apply the drops as soon as possible. If it's almost time for your next dose, you may skip the missed dose and continue with your regular dosing regimen. It is recommended to not double the dose to catch up.

To use Dexamethasone and Ofloxacin Eye Drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and instill the prescribed number of drops into the eye, then close your eyes gently and apply light pressure to the inner corner of the eye for a few seconds to ensure proper absorption.

Following are the conditions/situations when Dexamethasone, Ofloxacin Eye Drops should not be used:

• Should not be used if you have a known allergy or hypersensitivity to Dexamethasone, Ofloxacin, or any other similar antibiotics.
• Contraindicated in patients with a history of hypersensitivity or severe reactions to other quinolone antibiotics.
• Not suitable for individuals with a confirmed or suspected bacterial keratitis caused by organisms other than those susceptible to Ofloxacin.
• Should not be used in patients with a history of corneal ulceration or herpetic keratitis.
• Avoid using these eye drops if you have a corneal or scleral defect or a history of corneal graft.
• Contraindicated in patients with a history of myasthenia gravis.
• Not recommended for individuals with active tuberculosis.
• Should not be used in patients with a history of fungal, viral, or mycobacterial infections of the eye.
• Avoid using these eye drops if you have untreated or uncontrolled glaucoma.
• Contraindicated in patients with a history of ocular herpes simplex (except in rare cases where a doctor may decide to use it).

The side effects of Dexamethasone may include:

• Increased appetite and weight gain
• Indigestion or heartburn
• Difficulty sleeping (insomnia)
• Anxiety or restlessness
• Skin thinning or bruising
• High blood pressure
• Muscle weakness
• Delayed wound healing
• Eye redness or itching
• Mild eye burning or stinging
• Watery eyes
• Blurred vision
• Eye discharge
• Sensitivity to light
• Headache

Following are the precautions and warnings for Dexamethasone, Ofloxacin Eye Drops:

• Avoid using these drops if you have a known allergy to dexamethasone, ofloxacin, or any other ingredients in the formulation.
• Do not wear contact lenses while using these drops, and wait for the prescribed time after application before reinserting them.
• Prolonged use of corticosteroid eye drops like dexamethasone may lead to increased intraocular pressure, glaucoma, and cataracts. Regular eye pressure checks are advised.
• Bacterial resistance may develop with prolonged or repeated use, especially in chronic infections. Monitor for treatment failure.
• Ofloxacin may cause sensitivity to light; protect your eyes from direct sunlight or bright light during treatment.
• Not recommended for use in children or pregnant/breastfeeding women unless under medical supervision.
• If you have a history of corneal problems or herpes simplex keratitis, use with caution as corticosteroids may prolong the course of these conditions.

Following are the drug interactions for Dexamethasone, Ofloxacin Drop:

• Dexamethasone can increase the intraocular pressure when used with other drugs that have the same effect, such as corticosteroids and certain glaucoma medications.
• May reduce the efficacy of vaccines and interfere with skin tests when used concurrently.
• Ofloxacin may enhance the effects of oral anticoagulants, requiring close monitoring of prothrombin time.
• Theophylline blood levels may increase when used with Ofloxacin, leading to potential toxicity.
• Concurrent use with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of central nervous system stimulation and seizures.
• May reduce the effectiveness of live attenuated vaccines, such as measles, mumps, and rubella.
• Antacids containing magnesium or aluminum can decrease the absorption of Ofloxacin when taken simultaneously.

Following are the food interactions for Dexamethasone and Ofloxacin Drops:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and condiments, as Dexamethasone can cause sodium retention, leading to increased blood pressure.
• Maintain a consistent intake of potassium-rich foods such as bananas, oranges, and spinach to prevent potassium loss associated with Dexamethasone use.
• Avoid caffeine-rich beverages like coffee and energy drinks, as Dexamethasone may increase caffeine sensitivity, leading to heightened nervousness and insomnia.
• Ofloxacin drops may cause gastrointestinal issues; thus, it's advisable to consume a bland diet, avoiding spicy and acidic foods like citrus fruits and tomatoes.
• Ensure adequate hydration by drinking plenty of water, as Ofloxacin may cause dehydration and increase the risk of kidney stones.
• Avoid alcohol consumption, as it can exacerbate the potential gastrointestinal side effects of Ofloxacin and increase the risk of liver-related issues.
• There is no known direct food interaction with Ofloxacin drops, but maintaining a healthy and balanced diet is generally recommended.

Dexamethasone and Ofloxacin eye drops require proper storage and disposal to maintain their effectiveness and ensure safety. Store the eye drops in a clean, dry area at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Keep the bottle tightly sealed and protected from light by storing it in its original packaging or a dark container. Avoid freezing or exposing the drops to excessive heat, as this can damage the medication. Always check the expiration date and do not use the drops if they have expired. For disposal, do not pour the medication down the sink or flush it down the toilet. Contact your pharmacist or healthcare provider for instructions on proper disposal methods to minimize environmental impact. Keep the eye drops out of the reach of children and pets to prevent accidental exposure or ingestion.

No

Following are the quick tips for this:

• Administer the eye drops as directed by your doctor, typically 1-2 drops into the affected eye(s) every 4-6 hours.
• Wash your hands before applying the drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Close your eyes gently and apply light pressure to the inner corner of the eye for 1-2 minutes to minimize drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you wear contact lenses, remove them before using the eye drops and wait at least 15 minutes after administration before reinserting them.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Wash your hands thoroughly with soap and water before administering the eye drops.
• Tilt your head back slightly and gently pull down your lower eyelid to create a small pocket.
• Hold the dropper above your eye and squeeze the prescribed number of drops into the pocket.
• Close your eyes gently and apply light pressure to the inner corner of your eye for 1-2 minutes to minimize drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you wear contact lenses, remove them before using the eye drops and wait at least 15 minutes before reinserting them.
• Continue using the eye drops for the full prescribed duration, even if your symptoms improve, to ensure complete treatment.