Diamicron MR (30mg) 20 Tablets

Gliclazide is a medication used to treat type 2 diabetes by helping the body produce less glucose, especially during meals. When taken, it lowers blood sugar levels by stimulating the release of insulin from the pancreas, making it a sulfonylurea drug. Compared to other sulfonylureas, gliclazide is a second-generation selective drug for pancreatic beta cells, with a longer duration of action and less effect on thyroid and renal cells. Once ingested, it is hydrolyzed into gliclazide monohydrochloride in the intestine, absorbed into the bloodstream, and cleared from the blood by the kidneys. Gliclazide binds to sulfonylurea receptors on the beta cells, stimulating insulin release and decreasing blood glucose levels, while also inducing a minor release of insulin directly affecting the beta cells, decreasing glucose production in the liver. Additionally, it slows down the breakdown of starches into glucose and increases the absorption of glucose from the intestines. Typically, the starting dosage is 30mg once daily, adjustable depending on medication response and tolerance. All of these mechanisms combined ensure the body has enough insulin and can efficiently utilize, distribute, and dispose of glucose, keeping blood sugar levels stable.

Sulfonylurea

Unveiling its multifaceted uses and transformative applications as follows:

• Treatment for type 2 diabetes mellitus can include medications like gliclazide, which is a second-generation sulfonylurea hypoglycemic drug.
• Gliclazide aids in lowering blood glucose levels in patients with diabetes mellitus.
• This drug stimulates insulin secretion from the pancreas, which aids the process of blood glucose control.
• It is usually prescribed to patients when diet and exercise alone or metformin has not been enough to control blood glucose levels.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Dosage- 1-2 tablets of Gliclazide 30mg per day
• Modify dosage based on individual needs and response to treatment under doctor's guidance.

An overdose of gliclazide must be treated as a medical emergency, and those around the affected individual should immediately contact emergency services to alert them of the situation. The emergency services will be able to guide the caller on how to treat the overdose until medical personnel arrives at the scene. Depending on the level of overdose and its impact on the individual's health, there are several treatments that may be used. These include drugs such as insulin or sodium bicarbonate, which are given to restore normal blood sugar levels, managing the risk of complications. Should the overdose result in low blood sugar or other complications, intravenous fluids may be administered to treat it. In some cases, a gastric lavage may be performed to remove excess medication from the individual's stomach. For adequate monitoring and additional interventions where necessary, hospitalization is typically required. The severity of the overdose, symptoms exhibited by the individual, and their medical history will influence the specific treatment approach that medical personnel will adopt. It is vital to emphasize that a gliclazide overdose can have severe and life-threatening consequences. Thus, it is crucial to seek immediate medical attention if you or someone close to you has overdosed on gliclazide.

If you miss a dose of Gliclazide, it is important to take it as soon as possible. However, if it is almost time for your next dose, it is best to skip the missed dose and return to your regular dosage schedule. Do not take twice as much to catch up, as this may result in overdosing. If you are uncertain about whether you should take a missed dose or how to take it, reach out to your physician or pharmacist for guidance. If you forget to take your medication and it is close to your next scheduled dose, simply skip the missed dose. Then, take your next dose at the appointed time. If you have missed multiple doses, you may need to restart the medication under the guidance of your doctor. It is important to follow the recommended dosage schedule unless advised otherwise by your physician.

Gliclazide is a medication that is typically prescribed to those with blood sugar issues, and it is important to follow your physician's instructions carefully when taking this medication. This medication is taken either once or twice a day, depending on your physician's instructions and the dosage should be swallowed whole with water and taken at the same time each day to keep your blood levels consistent. If you miss a dose, you should take it as soon as possible, unless it is closer in time to your next scheduled dose, in which case you should skip the missed dose and resume your regular schedule. If you take too much of this medication, seek medical attention immediately. It is important to adhere to the dosing schedule as prescribed by your physician and to discuss any concerns or questions you may have about the medication with your healthcare provider. Depending on the severity of your condition, your dose may be altered throughout your treatment. Always check the dosage on the medication label if it looks different from what you are used to. If you suspect you have been given the wrong medication or dosage, inform your doctor or pharmacist as soon as possible. Remember, it is very important to follow the instructions provided with your medication and to only take Gliclazide as directed by your doctor.

Discerning instances where this medication may not be appropriate:

• Hypoglycemia (low blood sugar)

• Conditions induced by low blood sugar

• Acute conditions requiring hospitalization

• Pregnancy and breastfeeding

Unraveling the side effects lurking behind this medications are as follows:

• Low blood sugar (hypoglycemia)
• Upset stomach or indigestion
• Abdominal pain, diarrhea, and nausea
• Dizziness

Patients should use caution and consult a healthcare provider in the following situations:

• Risk factors for hypoglycemia, such as malnutrition, severe or poorly compensated endocrine disorders, or severe vascular disease.
• G6PD deficiency or porphyria.
• Stress-related states, including severe trauma, fever, infection, or surgery.
• Mild to moderate hepatic or renal impairment.
• Elderly individuals.

Drug interactions with gliclazide include:

• Insulin (may increase risk of hypoglycemia- monitor blood glucose levels closely)
• Other antidiabetic agents (e.g., metformin) (may increase risk of hypoglycemia- adjust doses as needed)
• CYP2C19 inhibitors (e.g., omeprazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
• Diuretics (e.g., furosemide) (may alter blood glucose levels- monitor blood glucose levels closely)
• Corticosteroids (e.g., prednisone) (may increase blood glucose levels- monitor blood glucose levels closely)
• Beta-blockers (e.g., propranolol) (may mask symptoms of hypoglycemia- monitor blood glucose levels closely)
• Alcohol (may enhance or diminish hypoglycemic effects- monitor blood glucose levels closely)
• Anticoagulants (e.g., warfarin) (may alter bleeding risk- monitor INR closely)

Gliclazide is a medication that should be stored at room temperature in a cool, dry place. Tablets should be kept in their original containers or packaging to ensure that the container is well-sealed and not exposed to moisture. It should also be kept out of reach of children or pets and securely stored to prevent accidental consumption. It is important to follow the storage instructions provided by a physician or pharmacist to affect the medication's effectiveness and safety. Improper storage can affect the medication's effectiveness and safety. If your medication has expired or is no longer needed, it is important to dispose of it properly to prevent harm to others and the environment.