Diamicron MR (60mg) 20 Tablets

Gliclazide is a medication used to treat adults with type 2 diabetes. It helps to control blood sugar levels by stimulating the pancreas to release more insulin, which helps to clear excess sugar from the blood. This makes it uniquely different from first-generation sulfonylureas, which act on both SUR1 and SUR2 receptors, whereas Gliclazide only acts on the beta-cell derived sulfonylurea receptor 1 (SUR1). This selective activity is responsible for its glycemic efficacy and reduced risk of hypoglycemia, or low blood sugar. Overall, Gliclazide is a safe and effective way to help manage blood sugar levels in adults with type 2 diabetes, and its action on SUR1 receptors reduces the chances of experiencing low blood sugar, a typical side effect of many other diabetes medications.

Sulfonylurea

Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus.
• Gliclazide is a second-generation sulfonylurea hypoglycemic drug.
• Helps lower blood glucose levels.
• Stimulates insulin release from the pancreas.
• Prescribed for adults.
• Used in combination with diet and exercise in the prevention of complications of diabetes mellitus.
• Can be used alone or in combination with metformin, an inhibitor of glucose absorption, or with a glitazone, a ligand for peroxisome proliferator-activated receptor gamma (PPARγ), a transcriptional regulator.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Managing type 2 diabetes- Take 1 tablet before breakfast and 1 tablet before dinner. The dose can be increased to a maximum of 160mg per day if needed, never more than 80mg in a single dose
• Managing glaucoma- Usual starting dose is 1 tablet of 60mg taken once a day in the morning.The dose may be increased up to a maximum of 160mg once a day if needed

An overdose of gliclazide must be treated as a medical emergency, and those witnessing or experiencing an overdose are strongly encouraged to seek immediate medical attention. It is crucial to contact local emergency services or a medical professional as soon as possible. While waiting for professional help to arrive, it may be necessary to perform gastric lavage (stomach pumping) to empty the stomach and administer activated charcoal, which binds to the drug remaining in the digestive system to prevent absorption. However, it is important to emphasize that both of these measures should be carried out under medical supervision as they may have side effects or create additional complications. Once stabilized, further treatment involves maintaining blood glucose levels within a safe range and addressing any underlying conditions that may have contributed to the overdose. In some cases, patients may need to be admitted to the hospital for close monitoring, additional medication, or interventions designed to manage the overdose and its potential complications. Seeking professional help promptly is paramount to effective treatment. It is pertinent to emphasize that the specific treatment required will depend on the circumstances behind the overdose and the condition of the patient.

If you miss a dose of Gliclazide 60mg, it is important to take it as soon as possible. If you remember within an hour or so of your usual dosing time, you may take the missed dose. This is because the drug is usually absorbed by your body within the first hour or so after swallowing. Absorption depends on the type of drug and your personal physiology, among other factors. After that time, it is recommended to dispose of the missed dose and continue with your regular schedule. If you miss multiple doses, this may result in an overdose and resultant potential complications. If you miss a dose and it is almost time for your next scheduled dose, advise your doctor rather than taking a double dose, this is because taking a double dose may result in an overdose or adverse reactions. To avoid missing doses, you can set an alarm on your phone, or keep a written schedule to help remind you when to take your medication. Alarms and reminders are practical reminders that have been used by many people to help them remember things they would otherwise forget. It is crucial to prioritize discussing any concerns or issues you may have regarding your medication with your healthcare provider, who can provide further guidance and advice based on your specific circumstances. If you have questions about the dose, the timing of the dose, potential interactions with other drugs you may be taking, or any other matter, your doctor is the best person to provide answers and guidance.

Before starting to take Gliclazide, you should read the medication guide provided by your pharmacist. If you have any questions, make sure to ask your doctor or pharmacist. Take the medication by mouth, usually three to four times a day with meals and a snack, as directed by your doctor. To reduce the risk of side effects, your doctor may increase your dose gradually. Continue taking Gliclazide even if you feel well and make sure to monitor your blood sugar levels regularly. If you start to experience some of the side effects listed in the medication guide, consult your doctor immediately. These side effects include nausea, vomiting, weakness, itchiness, rash, hives, difficulty swallowing, breathing, chest pain, palpitations, quickly falling blood pressure, and vision changes or eye pain. This medication may also cause dizziness, fatigue, or blurred vision.

Discerning instances where this medication may not be appropriate:

• Symptoms of low blood sugar include tremors, dizziness, sweating, or confusion.
• When sick or under stress, a doctor may advise you to adjust your Gliclazide dosage or delay dosage and monitor your blood sugar levels.
• Those with kidney or liver impairment should notify their doctor as they may require a different dosage or medication.
• It is important to consult a healthcare professional if you have any of these conditions or concerns.

Unraveling the side effects lurking behind this medications are as follows:

• Hypoglycemia (low blood sugar)
• Weight gain
• Tremors
• Flushing
• Altered liver function
• Cataract
• Hyperglycemia (high blood sugar)
• Kidney failure

Patients should use caution and consult a healthcare provider in the following situations:

• Risk factors for hypoglycemia, such as malnutrition, severe or poorly compensated endocrine disorders, or severe vascular disease.
• G6PD deficiency or porphyria.
• Stress-related states, including severe trauma, fever, infection, or surgery.
• Mild to moderate hepatic or renal impairment.
• Elderly individuals.

Drug interactions with gliclazide include:

• Insulin (may increase risk of hypoglycemia- monitor blood glucose levels closely)
• Other antidiabetic agents (e.g., metformin) (may increase risk of hypoglycemia- adjust doses as needed)
• CYP2C19 inhibitors (e.g., omeprazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
• Diuretics (e.g., furosemide) (may alter blood glucose levels- monitor blood glucose levels closely)
• Corticosteroids (e.g., prednisone) (may increase blood glucose levels- monitor blood glucose levels closely)
• Beta-blockers (e.g., propranolol) (may mask symptoms of hypoglycemia- monitor blood glucose levels closely)
• Alcohol (may enhance or diminish hypoglycemic effects- monitor blood glucose levels closely)
• Anticoagulants (e.g., warfarin) (may alter bleeding risk- monitor INR closely)

Gliclazide is a medication that should be stored at room temperature between 20°C and 25°C (68°F and 77°F). Avoid freezing, direct sunlight, or moisture. For safety purposes, keep the medication in a secure location, away from the reach of children and pets. It is important to consult a pharmacist or refer to the medication's label and packaging for specific instructions. Unused or expired medication should be disposed of accordingly to ensure safety and effectiveness. It is recommended to consult a healthcare professional for guidance on medication storage and precautions specific to you.