Dofnac (1%) 5ml Eye Drops

Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action primarily through the inhibition of cyclooxygenase (COX) enzymes, specifically COX-2. By blocking COX-2, diclofenac suppresses the production of prostaglandins, which are key mediators of inflammation and pain. This inhibition reduces the synthesis of prostaglandin precursors, arachidonic acid, thereby diminishing the inflammatory response. Diclofenac's ability to target COX-2 specifically allows it to exert its anti-inflammatory and analgesic effects while minimizing the gastrointestinal side effects associated with non-selective COX inhibition. This selective inhibition is a crucial aspect of diclofenac's mechanism, contributing to its effectiveness in managing pain and inflammation in various conditions.

Diclofenac

Nonsteroidal anti-inflammatory drug (NSAID)

Drop

The following are the uses of Diclofenac Drop:

• Used for relieving pain and reducing inflammation, especially in conditions like arthritis.
• Used for managing acute pain and swelling after injuries or surgeries.
• Used for treating headaches, toothaches, and other sources of pain.
• Used for reducing discomfort and inflammation in the eyes due to certain conditions.
• Used for providing targeted pain relief in specific areas.
• Used for easing menstrual cramps and pain.
• Used for improving mobility and reducing joint stiffness.

Follow these dosage instructions:

• Adult Dose

Use one drop in the affected eye three times a day, beginning 1 day before cataract surgery, continuing on the day of surgery, and for 2 weeks after the surgery.

• Child Dose

Use and dose must be determined by your doctor.

In the case of an overdose of Diclofenac Drops, several symptoms may occur, including nausea, vomiting, stomach pain, and in severe cases, kidney or liver damage. Immediate actions should be taken, such as contacting a healthcare professional or a poison control center for guidance. Prompt medical treatment may involve inducing vomiting or administering activated charcoal to prevent further absorption of the medication. It is crucial to seek medical assistance as soon as possible to minimize potential harm.

In the case of a missed dose of Diclofenac Drops, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting an alarm or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions about missed doses.

To administer Diclofenac Drops, gently squeeze the prescribed number of drops into the affected ear, ensuring the dropper does not touch the ear to maintain hygiene, and follow the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Diclofenac Drops should not be used:

• Do not use if you have a known allergy or hypersensitivity to Diclofenac or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Avoid using if you have a history of asthma attacks or severe allergic reactions triggered by aspirin or other NSAIDs.
• Not suitable for individuals with active stomach or intestinal bleeding or a history of gastrointestinal bleeding or perforation.
• Contraindicated in patients with severe heart failure or cardiovascular disease.
• Should not be used if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Not recommended for individuals with severe kidney or liver disease.
• Avoid using Diclofenac Drops if you have a history of peptic ulcers or gastrointestinal bleeding.
• Do not use if you are in the third trimester of pregnancy.
• Contraindicated in individuals with bleeding disorders or those taking blood thinners.
• Not suitable for children below a certain age (age limit may vary depending on the formulation and dosage).
• Avoid using if you have uncontrolled hypertension (high blood pressure).

The side effects of Diclofenac Drop may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Skin rash or itching
• Increased blood pressure
• Blurred vision

Following are the precautions and warnings for Diclofenac Drop:

• Do not use Diclofenac Drop if you are allergic to diclofenac or any other non-steroidal anti-inflammatory drugs (NSAIDs).
• This medication should be used with caution in patients with a history of gastrointestinal problems, as it may cause stomach bleeding or ulcers.
• Patients with a history of cardiovascular issues should be closely monitored, as NSAIDs may increase the risk of heart attack or stroke.
• Diclofenac Drop may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how the medication affects you.
• It is important to use the drops as directed and not exceed the recommended dosage. Overuse can lead to serious side effects.
• Pregnant and breastfeeding women should consult their doctor before using Diclofenac Drop, as it may have potential risks for the fetus or infant.
• This medication may interact with other drugs, so inform your healthcare provider about all medications you are currently taking.
• Stop using Diclofenac Drop and seek medical attention if you experience any severe side effects or allergic reactions.

Following are the drug interactions for Diclofenac Drops:

• Concurrent use with other non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids may increase the risk of gastrointestinal bleeding and ulcers.
• Aspirin may reduce the concentration of Diclofenac, potentially reducing its effectiveness.
• Lithium levels may be increased when used with Diclofenac, requiring close monitoring of lithium levels.
• Blood pressure medications like ACE inhibitors or beta-blockers may have reduced effectiveness when combined with Diclofenac.
• Diclofenac can increase the risk of bleeding when taken with anticoagulants, such as warfarin or heparin.
• Methotrexate levels may be elevated, increasing the risk of methotrexate toxicity.
• Diuretics, when used with Diclofenac, may decrease their diuretic effect and increase the risk of kidney problems.

Following are the food interactions for Diclofenac Drops:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Diclofenac.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Diclofenac, potentially increasing its levels in the body and the risk of side effects.
• Avoid high-sodium foods as Diclofenac can cause sodium retention, and a high-sodium diet may exacerbate this effect, leading to increased blood pressure.
• Limit fatty or greasy foods as Diclofenac is better absorbed on an empty stomach, and fatty meals can slow down its absorption.
• Avoid caffeine or reduce intake as Diclofenac may enhance the effects of caffeine, potentially leading to increased nervousness, irritability, and heart rate.
• Be cautious with herbal supplements, especially those affecting blood clotting (e.g., garlic, ginger, ginkgo) as they can increase the risk of bleeding when taken with Diclofenac.
• Consult a healthcare provider regarding dietary restrictions, especially if you have a history of gastrointestinal issues, as Diclofenac can cause gastrointestinal side effects.
• No significant interactions with specific foods, but maintaining a balanced diet is essential for overall health while using Diclofenac.

Diclofenac drops should be stored in a secure and child-resistant container, preferably in a cool and dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the drops in their original packaging, ensuring the bottle is tightly sealed to maintain its integrity. Avoid storing the medication in areas prone to temperature fluctuations, such as bathrooms or near heat sources, as this can impact its effectiveness. Regularly check the expiration date, and when the drops are no longer needed or have expired, proper disposal is essential. Do not dispose of them by pouring down the drain or flushing; instead, follow local guidelines or consult a pharmacist for safe disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental exposure.

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Following are the quick tips for Diclofenac Drop:

• Wash your hands before administering the drops to ensure hygiene.
• Check the dropper tip for any debris or cracks before use.
• Tilt your head back slightly and pull the lower eyelid to create a pocket.
• Hold the dropper above the eye and gently squeeze the prescribed number of drops into the pocket.
• Close your eye gently and blink to distribute the medication.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If using other eye medications, wait at least 5 minutes before applying the next medication.