Dopacone (50/12.5/200mg) 30 Tablets

Entacapone, Carbidopa, and Levodopa combination therapy works synergistically to manage Parkinson's disease symptoms. Levodopa is a precursor to dopamine, a neurotransmitter deficient in Parkinson's. It crosses the blood-brain barrier and is converted into dopamine, replenishing dopamine levels in the brain. Carbidopa, a peripheral decarboxylase inhibitor, prevents the breakdown of levodopa in the bloodstream, allowing more of it to reach the brain. This increases the bioavailability of levodopa and reduces its peripheral side effects. Entacapone, a catechol-O-methyltransferase (COMT) inhibitor, further enhances the effectiveness of levodopa by blocking the COMT enzyme, which is responsible for metabolizing dopamine. By inhibiting COMT, entacapone prolongs the action of dopamine in the brain, leading to improved motor function and symptom control in Parkinson's disease patients.

Entacapone, Carbidopa, Levodopa

Dopaminergic Parkinson combination

Oral

The following are the uses of Entacapone, Carbidopa, Levodopa Tablet:

• Used for treating Parkinson's disease and related movement disorders.
• Used to enhance the effectiveness of Levodopa in managing motor symptoms.
• Used to inhibit COMT enzyme, extending Levodopa's action time.
• Used to reduce "wearing-off" periods in Parkinson's patients.
• Used to improve motor control and decrease tremors.
• Used to promote dopamine production, enhancing muscle control.
• Used to manage fluctuations in Parkinson's symptoms.

To be used as per doctor's instructions

In the case of an overdose of Entacapone, Carbidopa, and Levodopa Tablets, individuals may experience symptoms such as nausea, vomiting, dizziness, and confusion. The severity of these symptoms can vary depending on the amount ingested. It is crucial to seek medical assistance promptly, as healthcare professionals can provide appropriate treatment to manage the overdose and prevent potential complications. Timely intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Entacapone, Carbidopa, and Levodopa Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen. It is important to maintain a consistent dosing schedule for this medication.

To take the Entacapone, Carbidopa, and Levodopa Tablet, swallow the tablet whole with a full glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken with or without food at the same time each day.

Following are the conditions or situations when Entacapone, Carbidopa, and Levodopa Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Entacapone, Carbidopa, or Levodopa, or any of the tablet's components.
• Contraindicated in patients with narrow-angle glaucoma.
• Not recommended for individuals with severe liver or kidney disease.
• Should not be used in patients with pheochromocytoma, a tumor of the adrenal gland.
• Contraindicated in people with severe cardiovascular disease or unstable hypertension.
• Not suitable for those who have experienced a previous neuroleptic malignant syndrome (NMS) episode.
• Should not be used in patients with severe pulmonary disease or respiratory failure.
• Contraindicated during breastfeeding as these drugs may pass into breast milk.

The side effects of Entacapone, Carbidopa, Levodopa Tablet may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Dry mouth
• Diarrhea
• Constipation
• Confusion or hallucinations
• Muscle twitching or involuntary movements
• Sleep disturbances, including vivid dreams or insomnia

Following are the precautions and warnings for Entacapone, Carbidopa, Levodopa Tablet:

• This medication should be used with caution in patients with a history of gastrointestinal, cardiovascular, respiratory, or psychiatric disorders, as it may worsen these conditions.
• Patients with a history of melanoma or other skin cancers should be monitored regularly during treatment.
• Patients may experience sudden sleep attacks or episodes of increased sleepiness during daily activities, such as driving, which can be dangerous.
• Not recommended for use in children, and caution should be exercised in elderly patients, as they may be more susceptible to side effects.
• Patients should avoid abrupt discontinuation of the medication to prevent withdrawal symptoms.
• Can cause orthostatic hypotension, so caution is advised when rising from a sitting or lying position.
• Patients with a history of liver disease should have their liver function monitored during treatment.
• It is important to inform your healthcare provider about all other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Entacapone, Carbidopa, and Levodopa Tablet:

• Iron salts can decrease the absorption of Levodopa, leading to reduced effectiveness.
• The combination with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) may increase the risk of serotonin syndrome, characterized by agitation, confusion, and rapid heart rate.
• When used with Tricyclic antidepressants, it may cause increased side effects such as confusion, hallucinations, and muscle twitching.
• Levodopa may enhance the effects of antihypertensive medications, leading to a more significant drop in blood pressure.
• It may interact with certain antipsychotics, reducing the effectiveness of both drugs.
• Combining with MAO inhibitors can lead to severe reactions, including high blood pressure and seizures.
• Concomitant use with certain anti-nausea medications may decrease the absorption of Levodopa.

Following are the food interactions for Entacapone, Carbidopa, Levodopa Tablet:

• This medication should be taken on an empty stomach, at least 30 minutes before meals or 2 hours after meals, to ensure optimal absorption.
• High-protein foods may reduce the absorption of Levodopa, so it is recommended to avoid protein-rich meals when taking this medication.
• Avoid aged, fermented, pickled, or smoked foods as they may contain a substance called tyramine, which can interact with Levodopa and cause a sudden increase in blood pressure.
• Foods rich in vitamin B6 (pyridoxine) like whole grains, nuts, and legumes, may reduce the effectiveness of Levodopa. Consider limiting these foods while on this medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Levodopa, leading to unpredictable drug levels in the body.
• Alcohol may affect the effectiveness of Entacapone and can also increase the risk of side effects, so it's best to limit or avoid alcohol consumption.
• Caffeine may interact with Levodopa, potentially reducing its effectiveness, so it is advisable to limit or avoid caffeinated beverages and foods.
• Consult your healthcare provider for specific dietary guidelines and adjustments, especially if you have any dietary restrictions or preferences.

Entacapone, Carbidopa, Levodopa Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Always check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Avoid flushing them down the toilet or pouring them into drains; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep this medication securely stored, out of the reach of children, to prevent accidental ingestion.

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Following are the quick tips for Entacapone, Carbidopa, Levodopa Tablet:

• Take the tablet as directed by your doctor, typically with meals to enhance absorption.
• Swallow the tablet whole without crushing or chewing for optimal effects.
• Maintain a consistent medication schedule by taking it at the same time daily.
• If you experience nausea, try taking the tablet with food to minimize discomfort.
• Avoid sudden discontinuation; consult your doctor for tapering instructions.
• Store the medication in a cool, dry place, away from sunlight and moisture.
• Keep a record of all medications you take and share this information with your healthcare providers.