Duodart (0.5/0.4mg) 30 Capsules

Dutasteride, one of the components in the capsule, acts by inhibiting both Type 1 and Type 2 isoforms of 5-alpha reductase enzymes, which are responsible for converting testosterone to dihydrotestosterone (DHT). By blocking this conversion, dutasteride reduces DHT levels in the body. DHT is a hormone that plays a key role in the development and enlargement of the prostate gland. Lowering DHT levels helps shrink the prostate, relieve urinary symptoms, and improve urine flow. Tamsulosin, the other component, is an alpha-blocker that works by relaxing the smooth muscles in the prostate and bladder neck. It achieves this by selectively blocking post-synaptic alpha-1 adrenergic receptors, leading to a reduction in the tone of the prostate and bladder neck muscles. This relaxation improves urine flow and reduces the symptoms associated with an enlarged prostate, such as difficulty in urination and the feeling of incomplete bladder emptying.

Dutasteride 0.5mg, Tamsulosin 0.4mg

5-alpha-reductase inhibitor, alpha-blocker.

Capsule

The following are the uses of Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule:

• Used for treating symptoms of an enlarged prostate, known as benign prostatic hyperplasia (BPH).
• Used to reduce the size of the prostate and improve urine flow.
• Used for managing symptoms like frequent urination, difficulty starting and maintaining a steady stream, and a feeling of incomplete bladder emptying.
• Used to relax the muscles in the prostate and bladder neck, making urination easier.
• Used for long-term management of BPH to improve quality of life.
• Used to reduce the risk of acute urinary retention and the need for prostate surgery.
• Used for its effectiveness in lowering levels of a hormone called dihydrotestosterone (DHT) that contributes to prostate growth.

This medicine is only for men, women and children cannot use it. The recommended dosage is one capsule daily.

In the case of an overdose of Dutasteride 0.5mg and Tamsulosin 0.4mg capsules, individuals may experience symptoms such as dizziness, lightheadedness, and a sudden drop in blood pressure. It is important to note that this combination medication is typically prescribed for men with benign prostatic hyperplasia, and an overdose may lead to an increased risk of adverse effects. If an overdose is suspected, immediate medical advice should be sought, and the individual should be closely monitored for any signs of severe hypotension or other cardiovascular complications.

In the case of a missed dose of Dutasteride 0.5mg, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Tamsulosin 0.4mg Capsule, if you miss a dose, take it as soon as you remember, but if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing routine. Do not double the dose to make up for a missed one. It is important to maintain a consistent medication schedule, so if you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track.

To take the Dutasteride 0.5mg and Tamsulosin 0.4mg Capsule, swallow the capsule whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider, ensuring you adhere to the prescribed schedule for optimal effectiveness.

Following are the conditions/situations when Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule should not be used:

• Should not be used in men with a known allergy to Dutasteride, Tamsulosin, or any other 5-alpha reductase inhibitors.
• Contraindicated in women and children. This medication is only for use in men.
• Not recommended for patients with severe liver disease as it may lead to increased side effects.
• Should not be used in men with a history of fainting spells related to low blood pressure.
• Contraindicated in individuals with a rare genetic condition called galactose intolerance or severe lactase deficiency.
• Not suitable for men who have difficulty passing urine or have a condition called urinary retention.
• Should not be used in patients with a known allergy to sulfonamides, as Tamsulosin is a sulfonamide derivative.

The side effects of Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule may include:

• Dizziness or lightheadedness
• Fatigue and weakness
• Impotence (erectile dysfunction)
• Decreased libido or sexual drive
• Ejaculation disorders, such as reduced ejaculate volume
• Skin rashes or itching
• Nasal congestion or runny nose
• Gastrointestinal issues like nausea, diarrhea, or abdominal pain

Following are the precautions and warnings for Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule:

• Not suitable for individuals with a known allergy to Dutasteride, Tamsulosin or any other ingredients in the capsule.
• Patients with a history of liver problems should use with caution, as these capsules may affect liver function.
• Men with a history of urinary retention or bladder obstruction should exercise caution, as Tamsulosin can affect urinary function.
• This medication may cause dizziness or fainting, especially when standing up quickly; patients should rise slowly and avoid activities that require alertness until the effects are known.
• Not recommended for use in women, especially those who are pregnant or breastfeeding, due to potential risks to the fetus or infant.
• Patients with eye problems, such as narrow-angle glaucoma, should inform their doctor before using this medication.
• Blood tests may be required to monitor liver function and PSA levels during treatment.
• Should be used with caution in elderly patients, as they may be more sensitive to the side effects.

Following are the drug interactions for Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule:

• Alpha-blockers like prazosin, terazosin, or doxazosin can cause a sudden drop in blood pressure when taken with Tamsulosin.
• Drugs metabolized by CYP3A4 enzyme, such as ketoconazole or verapamil, may increase the levels of Dutasteride.
• Anticoagulants (e.g., warfarin) may have enhanced effects when used with Tamsulosin, requiring close monitoring.
• Tamsulosin may increase the risk of orthostatic hypotension with other antihypertensive medications.
• Use with caution alongside phosphodiesterase-5 (PDE5) inhibitors (e.g., sildenafil, tadalafil) due to potential additive blood pressure-lowering effects.
• Antidepressants like fluoxetine or paroxetine can affect the metabolism of Tamsulosin, leading to increased side effects.
• Certain eye medications (e.g., timolol, latanoprost) may have additive effects on blood pressure when used with Tamsulosin.
• Opioid pain medications can increase the risk of urinary retention and other side effects when combined with Tamsulosin.

Following are the food interactions for Dutasteride 0.5mg, Tamsulosin 0.4mg Capsule:

• Grapefruit juice should be avoided as it may increase the absorption of Tamsulosin, leading to higher drug levels in the blood and potentially increasing the risk of side effects.
• Alcohol consumption should be limited as it can cause excessive drops in blood pressure, especially when combined with Tamsulosin, leading to dizziness and lightheadedness.
• Avoid high-fat meals as they may decrease the absorption of Dutasteride, reducing its effectiveness.
• Caffeine intake should be monitored as Tamsulosin may enhance the effects of caffeine, potentially causing increased heart rate and blood pressure fluctuations.
• Avoid salty foods as Tamsulosin may increase the sensitivity to sodium, affecting blood pressure control.
• Do not consume large amounts of citrus fruits or juices as they may interfere with Dutasteride absorption.
• Be cautious with spicy foods as they can sometimes worsen symptoms of benign prostatic hyperplasia, and may interact with Tamsulosin's effects.
• Always stay hydrated and maintain a balanced diet, as proper hydration and nutrition can support overall health and medication effectiveness.

Dutasteride 0.5mg, Tamsulosin 0.4mg Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the capsules away from heat sources, such as radiators or stoves, as temperature fluctuations can impact their effectiveness. Always check the expiration date, and dispose of any unused or expired capsules responsibly. Do not dispose of them via wastewater or drains; instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Additionally, ensure the medication is stored securely, out of children's reach, to prevent accidental consumption.

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Here are the quick tips for Dutasteride 0.5mg and Tamsulosin 0.4mg Capsule:

• Consult your doctor before starting this medication for personalized advice.
• Take the capsule as directed by your doctor, usually once daily, for best results.
• Swallow the capsule whole with a full glass of water; do not crush or chew.
• Maintain consistency by taking your dose at the same time each day.
• Do not miss doses; if you do, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor if you have any allergies or medical conditions before taking this medication.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.