Ecasil (200mg) 100ml Ampoule Infusion

Linezolid, a 200mg infusion, exerts its antibacterial effect through a unique mechanism of action. It inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, specifically near the peptidyl transferase center. This binding prevents the formation of a functional ribosome, disrupting the initiation complex and elongation processes required for protein synthesis. Linezolid's specificity for bacterial ribosomes, rather than eukaryotic ribosomes, contributes to its selective toxicity towards bacteria, making it an effective agent against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

Linezolid 200mg

Oxazolidinone antibiotic

Infusion

The following are the uses of Linezolid 200mg Infusion:

• Used for treating severe bacterial infections that are resistant to other antibiotics.
• Used for controlling bacterial growth in life-threatening conditions like pneumonia and skin structure infections.
• Used for managing infections caused by specific bacteria, such as MRSA (Methicillin-resistant Staphylococcus aureus).
• Used for treating infections in patients with weakened immune systems or those undergoing medical procedures.
• Used as a last-resort antibiotic when other treatments have failed.
• Used for rapidly controlling bacterial infections that require immediate attention.
• Used for preventing the spread of drug-resistant bacteria in hospitals and healthcare settings.

In the case of an overdose of Linezolid 200mg Infusion, prompt medical intervention is necessary. Symptoms may include severe nausea, vomiting, diarrhea, and potential neurological effects such as dizziness or seizures. It is crucial to contact a healthcare professional or seek emergency medical care immediately. They will provide appropriate treatment and support to manage the overdose and minimize any potential harm or adverse effects.

In the case of a missed dose of Linezolid 200mg Infusion, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. However, if multiple doses have been missed, contact your healthcare provider for guidance on how to proceed with the medication. It is crucial to maintain a consistent dosing regimen for the treatment to be effective.

To administer Linezolid 200mg Infusion, mix the contents with the provided sterile diluent, ensuring proper mixing, and then slowly infuse the prepared solution intravenously over 30 to 120 minutes as directed by your healthcare professional.

Following are the conditions when Linezolid 200mg Infusion should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Linezolid or any other ingredients in the infusion.
• Contraindicated in patients with a history of myelosuppression or bone marrow suppression.
• Not suitable for individuals with uncontrolled hypertension (high blood pressure).
• Should not be used in patients with a history of seizures or conditions that lower the seizure threshold.
• Contraindicated in individuals with known or suspected carcinoid tumors.
• Must not be used in patients with a history of optic neuritis or optic nerve damage.
• Not recommended for individuals with severe kidney disease or those on dialysis.

The side effects of Linezolid 200mg Infusion may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Dry mouth
• Changes in taste
• Skin rashes or itching
• Peripheral neuropathy (numbness or tingling in hands and feet)

Following are the precautions and warnings for Linezolid 200mg Infusion:

• Not recommended for individuals with a known hypersensitivity or severe allergic reaction to Linezolid or any of its components.
• Linezolid should be used with caution in patients with a history of seizures or conditions that lower the seizure threshold, as it may increase the risk of seizures.
• Caution is advised in patients with liver or kidney impairment, as dosage adjustments may be necessary.
• Patients with a history of blood disorders or those taking medications that affect blood clotting should be monitored closely as Linezolid can interfere with blood clotting.
• Not recommended for long-term use, as prolonged use may lead to the development of antibiotic-resistant bacteria.
• Patients should inform their doctor if they have a history of high blood pressure or cardiovascular disease before starting Linezolid treatment.
• Pregnant and breastfeeding women should consult their healthcare provider as Linezolid may pose risks to the fetus or infant.

Following are the drug interactions for Linezolid 200mg Infusion:

• Linezolid may interact with serotonergic drugs like SSRIs, increasing serotonin levels and causing serotonin syndrome.
• Contraindicated with monoamine oxidase inhibitors (MAOIs) as it can lead to severe reactions, including serotonin syndrome.
• May reduce the effectiveness of hormonal contraceptives, requiring alternative birth control methods.
• Linezolid can increase the effects of anticoagulants, raising the risk of bleeding.
• Drugs metabolized by CYP450 enzymes may have increased levels when taken with Linezolid.
• CYP450 inducers might decrease Linezolid concentrations, potentially reducing its efficacy.
• Drugs with similar side effects, such as neurologic or hematologic effects, may have additive side effects when used with Linezolid.

Following are the food interactions for Linezolid 200mg Infusion:

• Avoid tyramine-rich foods like aged cheeses, cured meats, fermented foods, and certain types of beans, as Linezolid can interact with tyramine and lead to a sudden increase in blood pressure.
• Foods high in sodium and potassium should be consumed with caution, as Linezolid can affect electrolyte balance.
• Grapefruit and grapefruit juice should be avoided due to their potential to increase Linezolid levels in the blood.
• Limit the consumption of foods containing high levels of monoamine oxidase inhibitors (MAOIs), such as aged cheeses, fermented soy products, and certain legumes.
• Alcohol intake should be minimized or avoided, as it may increase the risk of side effects and alter Linezolid's effectiveness.
• Linezolid may cause a decrease in appetite, so ensure you maintain a balanced diet to meet nutritional requirements.
• Consider consulting a healthcare professional or dietician for personalized dietary recommendations during Linezolid treatment.

Linezolid 200mg Infusion should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C) with occasional excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the infusion from light and store it in its original packaging to maintain its integrity. Avoid freezing the medication as it may affect its potency. Once the infusion is prepared, it should be used promptly, and any unused portions should be discarded. Proper disposal of the infusion is crucial; do not pour it down the drain or flush it into the sewage system. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to protect the environment and prevent accidental exposure. Keep the medication out of the reach of children and pets to ensure their safety.

Following are the quick tips for Linezolid 200mg Infusion:

• Administer the infusion as directed by your healthcare professional, ensuring the prescribed dosage and duration.
• Before starting the infusion, check the solution for any discoloration or particles.
• Use a sterile infusion set and ensure proper aseptic technique during administration.
• Infuse the medication over the recommended time period as instructed by your doctor.
• Monitor vital signs during and after the infusion, and report any adverse reactions promptly.
• Store the infusion as directed on the label, away from direct sunlight and moisture.
• Do not use if the solution appears cloudy or if the seal is broken; discard it safely.