Entamizole (500/400mg) 30 Tablets

Diloxanide Furoate acts by inhibiting the uptake of nutrients by the amoebic parasites, leading to their death. It specifically targets the amoebic trophozoites in the intestinal lumen, preventing their ability to feed and multiply. On the other hand, Metronidazole exerts its effect by disrupting the DNA structure of susceptible anaerobic bacteria and protozoa, leading to their destruction. Metronidazole is particularly effective against anaerobic organisms due to its ability to penetrate these microorganisms and interfere with their nucleic acid synthesis.

Antiparasitic, Antibiotic.

Oral

The following are the uses of Diloxanide Furoate 500mg, Metronidazole 400mg Tablet:

• Used for treating intestinal amoebiasis, effectively eliminating amoebic parasites.
• Used to cure infections caused by amoebae, particularly in the intestines.
• Used to eliminate Giardia lamblia, a parasite causing diarrhea and gastrointestinal issues.
• Used for managing amoebic liver abscesses, reducing abscess-related complications.
• Used to alleviate symptoms like abdominal pain, diarrhea, and gastrointestinal discomfort.
• Used as an anti-infective agent, targeting specific parasites with minimal side effects.
• Used in combination with other medications for comprehensive parasitic treatment.
• Used for preventing amoebic infections in high-risk individuals or travelers.

Follow these dosage instructions:

• 1-2 tablets taken orally 3 times a day for 5-10 days.

Note

In the case of an overdose of Diloxanide Furoate 500mg and Metronidazole 400mg tablets, individuals may experience gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Additionally, there could be neurological effects like dizziness, headache, and confusion. It is important to seek medical advice promptly, as treatment may involve supportive care and management of symptoms. Timely intervention can help mitigate potential health risks associated with an overdose of these medications.

In the case of a missed dose of Diloxanide Furoate 500mg, take it as soon as you remember, unless it is almost time for your next dose. You can then continue with your regular dosing schedule. For Metronidazole 400mg Tablet, if you miss a dose, take it as soon as you remember within a 2-hour window. If it has been more than 2 hours, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

To take Diloxanide Furoate 500mg and Metronidazole 400mg tablets, swallow the tablets whole with a full glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Diloxanide Furoate 500mg and Metronidazole 400mg Tablet should not be used:

• Should not be used if you have a known allergy or hypersensitivity to Diloxanide Furoate, Metronidazole, or any other similar medications.
• Contraindicated in patients with a history of blood disorders or central nervous system diseases.
• Not recommended for individuals with liver or kidney disease.
• Avoid using if you have a history of gastrointestinal diseases or conditions.
• Should not be used if you are currently taking alcohol or disulfiram-containing medications.
• Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.
• Not suitable for children under a certain age (consult a doctor for specific age restrictions).
• Should be used with caution and only if prescribed by a doctor for elderly patients.

The side effects of Diloxanide Furoate 500mg, Metronidazole 400mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Metallic taste in the mouth
• Dry mouth
• Headache
• Dizziness
• Darkening of urine

Following are the precautions and warnings for Diloxanide Furoate 500mg, Metronidazole 400mg Tablet:

• Do not take this medication if you have a known allergy to Diloxanide Furoate or Metronidazole or any other ingredients in the tablet.
• This medication may cause dizziness and blurred vision, so caution is advised when performing activities that require clear vision and mental alertness, such as driving or operating machinery.
• Patients with liver or kidney disease should exercise caution and consult a doctor as the dosage may need to be adjusted.
• Alcohol consumption should be avoided as it may cause an unpleasant reaction with Metronidazole.
• Do not take this medication if you are pregnant or breastfeeding without consulting a healthcare professional, as it may be harmful to the fetus or infant.
• If you have a history of blood disorders or central nervous system disorders, inform your doctor before taking this medication.
• Do not exceed the prescribed dosage, as it may increase the risk of side effects and adverse reactions.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for Diloxanide Furoate 500mg and Metronidazole 400mg Tablet:

• Alcohol consumption should be avoided, as Metronidazole may cause a disulfiram-like reaction with alcohol, leading to nausea, vomiting, and flushing.
• Concurrent use with warfarin may increase the risk of bleeding due to Metronidazole's potential to enhance warfarin's anticoagulant effects.
• It may reduce the effectiveness of oral contraceptives, so alternative contraception methods should be considered.
• Diloxanide Furoate may interact with other antiparasitic drugs, potentially affecting the treatment outcome.
• Drugs that increase gastric pH, such as proton pump inhibitors, may decrease the absorption of Metronidazole.
• Metronidazole can cause central nervous system (CNS) effects, and these may be enhanced when combined with other CNS depressants.
• Certain antibiotics, like rifampicin, can induce liver enzymes and potentially reduce the efficacy of Metronidazole.

Following are the food interactions for Diloxanide Furoate 500mg and Metronidazole 400mg Tablet:

• Alcohol consumption should be avoided as it can interfere with the effectiveness of Metronidazole, leading to reduced therapeutic effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the concentration of Metronidazole in the blood, potentially enhancing its side effects.
• Dairy products like milk and cheese can decrease the absorption of Diloxanide Furoate, so it is advisable to separate their intake by a few hours.
• High-fat meals can delay the absorption of Metronidazole, so it is best to take the medication on an empty stomach.
• Avoid excessive consumption of spicy foods as they can irritate the gastrointestinal tract, potentially worsening any existing discomfort.
• Limit caffeine intake from coffee or energy drinks as it can exacerbate nervousness and insomnia, which are possible side effects of Metronidazole.
• Ensure adequate hydration by drinking plenty of water, especially when taking Metronidazole, to reduce the risk of nausea and dehydration.
• There are no specific food restrictions for Diloxanide Furoate, but maintaining a balanced diet is generally recommended for overall health.

Diloxanide Furoate 500mg and Metronidazole 400mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. It is recommended to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid storing them in bathrooms or areas exposed to heat, as temperature fluctuations can impact their effectiveness. Proper disposal of any unused or expired tablets is crucial; do not dispose of them in sinks or toilets. Consult your pharmacist or healthcare professional for safe disposal practices. Always keep medications out of children's reach to prevent accidental consumption. Adhering to these guidelines ensures the safety and efficacy of the medication.

No

Following are the quick tips for Diloxanide Furoate 500mg and Metronidazole 400mg Tablet:

• Take the medication as directed by your doctor to effectively treat the infection.
• Ensure you complete the full course of treatment, even if you feel better.
• Swallow the tablets whole with water; do not crush or chew.
• Avoid alcohol consumption while taking Metronidazole to prevent adverse reactions.
• Store the medication in a cool, dry place, away from direct sunlight.
• Inform your doctor if you have any known allergies before starting the medication.
• Contact your healthcare provider if you experience severe side effects or symptoms persist.