Evofix (400mg) 10 Capsules

Cefixime 400mg capsules exhibit their antibacterial activity through a specific mechanism of action. Cefixime primarily inhibits bacterial cell wall synthesis by binding to and blocking the activity of penicillin-binding proteins (PBPs), which are essential enzymes responsible for cross-linking peptidoglycan strands in the bacterial cell wall. By inhibiting PBPs, Cefixime disrupts the formation of a strong and stable cell wall, leading to weakened bacterial cell structure and ultimately cell lysis. This mechanism is particularly effective against susceptible bacteria, as it interferes with a vital process required for their growth and survival.

Cefixime 400mg

Cephalosporin antibiotic

Capsule

The following are the uses of Cefixime 400mg Capsule:

• Used for treating bacterial infections, particularly those caused by susceptible bacteria.
• Used for respiratory tract infections like pneumonia and bronchitis.
• Used for treating urinary tract infections, effectively eliminating bacteria.
• Used for skin and soft tissue infections, promoting healing.
• Used for bone and joint infections, providing targeted treatment.
• Used for preventing and controlling infections during surgery.
• Used for managing severe infections that require high-dose antibiotics.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For Adults-
• Dosage ranges from 400-800 mg a day
• Maximum dose of 1600 mg per day
• For Children-
• Dosage recommended is 10 mg/kg of body weight once a day
• Maximum of 400 mg per day

In the case of an overdose of Cefixime 400mg Capsules, it is important to recognize the signs and symptoms, which may include nausea, vomiting, diarrhea, and abdominal pain. If an overdose is suspected, seek medical advice promptly. Treatment may involve monitoring and supportive care, ensuring the patient's vital signs are stable and managing any adverse effects. Quick action can help prevent potential complications and ensure the best possible outcome. Always keep medications out of reach of children to prevent accidental ingestion.

In the case of a missed dose of Cefixime 400mg Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to resume your medication safely. Always consult your doctor or pharmacist if you are unsure about how to manage missed doses.

To take Cefixime 400mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, either with or without food, as directed by your healthcare professional.

Here are the circumstances where Cefixime 400mg Capsule should not be administered:

• Avoid use in individuals with a known allergy to Cefixime or other cephalosporin antibiotics.
• Not suitable for patients with a history of severe gastrointestinal diseases, especially colitis.
• Contraindicated in patients with severe kidney impairment or kidney failure.
• Do not administer to patients with a history of severe allergic reactions to any medication.
• Should not be used in infants below 6 months of age due to potential risks.

The side effects of Cefixime 400mg Capsule may include:

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Skin rash or itching
• Headache
• Dizziness
• Vaginal yeast infection
• Fatigue

Following are the precautions and warnings for Cefixime 400mg Capsule:

• Do not take this medication if you are allergic to Cefixime or any other cephalosporin antibiotics.
• Cefixime should be used with caution in patients with kidney disease or impairment, as dosage adjustments may be necessary.
• Inform your doctor if you have a history of gastrointestinal diseases as it may cause diarrhea, and in rare cases, Clostridium difficile-associated diarrhea.
• This medication may decrease the effectiveness of hormonal birth control methods, so it is advised to use alternative contraception during treatment.
• Elderly patients may be more susceptible to the side effects of Cefixime, hence regular monitoring is required.
• Cefixime should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
• Avoid alcohol consumption while taking Cefixime as it may increase the risk of certain side effects.

Following are the drug interactions for Cefixime 400mg Capsule:

• Probenecid can decrease the renal excretion of cefixime, potentially leading to increased plasma concentrations.
• Concurrent use with other nephrotoxic drugs may increase the risk of renal toxicity.
• Cefixime may reduce the effectiveness of oral contraceptives, so additional contraceptive measures are recommended.
• The absorption of Cefixime can be decreased by antacids containing aluminum and magnesium hydroxide, as well as iron-containing preparations.
• May increase the risk of bleeding when taken with anticoagulants, such as warfarin.
• Cefixime can potentially affect the metabolism of drugs metabolized by the liver, including certain antiepileptic medications.
• Concurrent use with other antibiotics, such as aminoglycosides, may increase the risk of adverse effects on the kidneys and hearing.

Following are the food interactions for Cefixime 400mg Capsule:

• Avoid consuming alcohol with this medication as it may reduce the absorption of Cefixime, decreasing its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Cefixime in the blood, potentially leading to an increased risk of side effects.
• Dairy products like milk, yogurt, and cheese should be separated from the medication as they can decrease the absorption of Cefixime. Take the medicine at least 2 hours before or after consuming dairy.
• High-fat meals can delay the absorption of Cefixime, so it is best to take the medicine on an empty stomach.
• Avoid caffeine-rich foods and beverages as they may increase the elimination of Cefixime, reducing its effectiveness.
• Vitamin C supplements or citrus fruits may decrease the absorption of Cefixime, so it's best to separate their consumption by a few hours.
• Avoid iron-rich foods or supplements as they can decrease the absorption of Cefixime. Take the medicine at least 2 hours before or after consuming iron supplements.
• Probiotics and fermented foods should be consumed with caution as they may decrease the effectiveness of Cefixime by altering the gut flora.

Cefixime 400mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct exposure to sunlight and moisture. Keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to store it away from heat sources like heaters or ovens, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired capsules responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Cefixime 400mg Capsule:

• Swallow the capsule whole with a full glass of water; do not crush, chew, or break it.
• Take the capsule with or without food as directed by your doctor.
• Maintain a consistent daily dose to ensure effective treatment.
• Avoid missing doses; take it at the same time each day to establish a routine.
• Complete the full course of medication as prescribed, even if you feel better earlier.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor if you have any allergies or medical conditions before taking this medication.

Cefixime is a medication that belongs to the antibiotic class of drugs and is known to be effective in treating various bacterial infections. While it can be quite effective, it is important to stress that this medication does have its potential drawbacks and side effects just like any other medication.One of the most important things to note about Cefixime is that it is not suitable for everyone. There is a possibility that this medication could interact negatively with other medications that the patient is currently taking, or it may exacerbate certain medical conditions that the patient is dealing with or cause allergic reactions due to pre-existing allergies. Thus, it is crucial to inform your healthcare provider of all your medical history and the medications you take.In terms of the clinical implications, it is recommended that patients undergo certain laboratory tests while using this medication. Such tests include monitoring kidney function through blood tests that examine serum creatinine and blood urea nitrogen levels. These tests are important because this medication does put stress on the kidneys, and as a result, it is important to ensure that the kidneys are functioning properly. If they are not, it might be necessary to adjust the dosage of Cefixime or consider alternative treatment options. Given that this medication can cause bleeding issues in some patients, it is possible that your doctor will also want to monitor your complete blood count (CBC). This will help ensure that your blood is healthy and free of abnormalities, such as low levels of platelets, which are critical for healthy blood clotting. Remember, however, that these tests are not mandatory for everyone taking Cefixime. Their necessity will depend on individual circumstances and the opinions of healthcare professionals. In summary, whilst Cefixime is a useful medication for fighting bacterial infections, at any point you experience side effects or notice anything abnormal whilst taking this medication, you should consult a medical professional who can provide personalized advice, and if needed, recommend alternative treatment options.