Exforge HCT (10/160/12.5mg) 14 Tablets

The combination of Amlodipine, Valsartan, and Hydrochlorothiazide in this tablet works synergistically to lower blood pressure through multiple mechanisms of action. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral vascular resistance. Valsartan, an angiotensin II receptor blocker, blocks the binding of angiotensin II to its receptors, resulting in relaxation of blood vessels and decreased blood pressure. Hydrochlorothiazide, a thiazide diuretic, increases urinary excretion of sodium and water, reducing plasma volume and subsequently lowering blood pressure. Together, these mechanisms contribute to the effective management of hypertension by reducing systemic vascular resistance and promoting fluid elimination.

Amlodipine 10mg, Valsartan 160mg, Hydrochlorothiazide 12.5mg

Angiotensin II blocker, calcium channel blocker, diuretic.

Tablet

The following are the uses of Amlodipine 10mg, Valsartan 160mg, Hydrochlorothiazide 12.5mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to relax and widen blood vessels, reducing strain on the heart
• Used to eliminate excess fluid and salt, helping to lower blood pressure
• Used for improving blood flow and reducing the risk of cardiovascular events
• Used in the management of hypertension and related heart conditions
• Used to prevent symptoms like chest pain and reduce the risk of heart attacks
• Used for long-term management of blood pressure and cardiovascular health
• Used to control hypertension in patients who haven't responded to other treatments

To be taken as per doctor's prescription

In the case of an overdose of Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg tablets, the symptoms may include severe hypotension, which can lead to dizziness, fainting, and even shock. Other possible effects include an increased heart rate, electrolyte imbalances, and potential kidney dysfunction. Prompt medical intervention is vital, and emergency services should be contacted immediately. It is crucial to seek professional help to manage the potential complications and ensure appropriate treatment.

In the case of a missed dose of Amlodipine 10mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. For Valsartan 160mg and Hydrochlorothiazide 12.5mg, if a dose is missed, take it as soon as possible on the same day. However, if it's close to the time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day as directed by your healthcare provider. Ensure you follow the prescribed dosage and do not crush, chew, or break the tablet.

The following are the conditions or situations when Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet should not be taken:

• Avoid if you are allergic to any of the active ingredients (amlodipine, valsartan, hydrochlorothiazide) or any other ACE inhibitors, ARBs, or sulfonamide-derived drugs.
• Do not take if you are pregnant or planning to become pregnant.
• Contraindicated in individuals with severe liver disease or biliary obstruction.
• Should not be used if you have a history of angioedema or hereditary angioedema.
• Not suitable for patients with severe kidney disease or those who are unable to urinate.
• Avoid if you have a condition called aortic stenosis (narrowing of the aortic valve in the heart).

The side effects of Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Increased urination
• Joint or muscle pain

Following are the precautions and warnings for Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet:

• This medication is not recommended for individuals with known allergies to amlodipine, valsartan, hydrochlorothiazide, or any other ingredients in the tablet.
• Patients with a history of liver or kidney problems should use this medication with caution, as it may require dosage adjustments under medical supervision.
• Amlodipine may cause dizziness; patients should be cautious when performing tasks that require alertness, such as driving or operating heavy machinery.
• Valsartan can cause excessive potassium loss, so monitoring of potassium levels is necessary, especially in patients with kidney disease.
• Hydrochlorothiazide is a diuretic and may lead to dehydration and electrolyte imbalances; regular monitoring of fluid and electrolyte levels is essential.
• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of side effects and affect blood pressure.
• Inform your doctor if you have any pre-existing medical conditions, such as heart disease, diabetes, or systemic lupus erythematosus, as this medication may require special monitoring.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.

Following are the drug interactions for Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet:

• Amlodipine may increase the blood levels of Valsartan, leading to enhanced blood pressure-lowering effects.
• Concomitant use with nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the antihypertensive effects of Amlodipine and Valsartan.
• Hydrochlorothiazide may decrease the elimination of lithium, increasing the risk of lithium toxicity.
• The diuretic effects of Hydrochlorothiazide can be reduced by NSAIDs, leading to decreased blood pressure control.
• Caution is advised when combining this medication with other drugs affecting potassium levels, as it may cause hyperkalemia.
• Valsartan may increase the levels of potassium-sparing diuretics, potentially leading to hyperkalemia.
• The antihypertensive effects of Amlodipine and Valsartan may be enhanced by other blood pressure-lowering medications, requiring close monitoring.

Following are the food interactions for Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Amlodipine in the blood, leading to potential side effects like dizziness and rapid heartbeat.
• Avoid excessive alcohol consumption as it may interact with Valsartan, causing increased dizziness and a drop in blood pressure.
• Limit your salt and potassium-rich food intake while on Hydrochlorothiazide; excessive salt can reduce the medication's effectiveness, and potassium-rich foods may need to be balanced due to the diuretic's potassium-wasting effect.
• Avoid licorice, especially if you have heart issues, as it can interact with Amlodipine, causing an irregular heartbeat.
• Inform your doctor if you consume large amounts of dairy, as calcium can potentially interact with Hydrochlorothiazide's absorption.
• Be cautious with vitamin D supplements or fortified foods, as high doses can interact with Hydrochlorothiazide's calcium balance.
• Avoid or limit high-fat meals as they may affect the absorption of Valsartan.
• Always follow healthcare provider instructions regarding dietary restrictions and recommendations.

Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablets should be stored in a cool, dry place at room temperature, typically between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas can be too warm and humid. It is crucial to keep the medication out of the reach of children and pets. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines for medication disposal, which may include returning them to a pharmacy or a designated collection point for safe disposal.

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Following are the quick tips for Amlodipine 10mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg Tablet:

• Consult your doctor or pharmacist for personalized instructions.
• Take the tablet as directed, usually once daily.
• Consume the tablet whole with a full glass of water.
• Maintain a consistent daily routine for better effectiveness.
• Avoid crushing, chewing, or breaking the tablet.
• Store the medication in a cool, dry place, away from light and moisture.
• Inform your doctor about all medications you are taking to prevent interactions.
• Do not stop taking the medication without consulting your healthcare provider.