Exocin (0.3%) 5ml Eye Drops

Ofloxacin, a fluoroquinolone antibiotic, exerts its bactericidal effect by directly inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. These enzymes are responsible for maintaining the topology of DNA, and their inhibition leads to DNA damage and subsequent cell death. The primary target of ofloxacin is DNA gyrase, a type II topoisomerase, which is composed of two A subunits and two B subunits. Ofloxacin binds to the A subunit of DNA gyrase, blocking its activity and preventing the relaxation of supercoiled DNA, which is crucial for various DNA processes within the bacterial cell. This mechanism of action results in the disruption of bacterial DNA synthesis and ultimately leads to the death of susceptible bacteria.

Quinolone antibiotic

Drop

The following are the uses of Ofloxacin Drop:

• Used for treating bacterial eye infections such as conjunctivitis.
• Used for reducing inflammation and pain caused by bacterial eye infections.
• Used for preventing the spread of bacterial eye infections.
• Used for managing post-operative eye infections and inflammation.
• Used for treating corneal ulcers caused by bacteria.
• Used for improving eye comfort and reducing discharge.
• Used for preventing eye infections in high-risk situations.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Ear infections- Drop of Ofloxacin 0.3% in each infected ear, twice a day for adults and children older than 1.
• Skin infections- A thin layer applied to the infected area twice a day for adults and children older than 8.

In the case of an overdose of Ofloxacin Drops, it is important to act swiftly. First, remove any unabsorbed medication from the eyes and consult a healthcare professional or poison control center for guidance. They will provide specific instructions based on the severity of the overdose. Prompt action is key to managing potential adverse effects and ensuring the best possible outcome. Always keep medications out of reach of children to prevent accidental ingestion.

In the case of a missed dose of Ofloxacin Drops, it is important to administer the medication as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for guidance on how to safely resume the medication without compromising its effectiveness. It is recommended to use the drops within a certain timeframe after opening the bottle, so be mindful of the expiration date as well.

To use Ofloxacin eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper tip close to but not touching your eye, then squeeze the prescribed number of drops into the pocket, blinking gently to allow the medication to spread over the eye's surface.

Following are the conditions/situations when Ofloxacin Eye Drops should not be used:

• Avoid using Ofloxacin drops if you have a known allergy to Ofloxacin or any other quinolone antibiotics.
• Do not use if you have or suspect a perforated or punctured eardrum.
• Not recommended for individuals with a history of tendon disorders or tendon rupture.
• Contraindicated in patients with epilepsy or conditions that increase the risk of seizures.
• Should not be used in children or adolescents, especially during stages of growth and development.
• Avoid using if you have a condition where you experience prolonged periods of sunlight exposure.
• Not suitable for individuals with a history of hypersensitivity or severe reactions to other quinolone antibiotics.

The side effects of Ofloxacin Drop may include:

• Stinging or burning sensation in the eye
• Redness or itching of the eye
• Watery eyes
• Blurred vision
• Sensitivity to light (photophobia)
• Eye discharge
• Headache
• Skin rash or itching

Following are the precautions and warnings for Ofloxacin Eye Drops:

• Avoid using Ofloxacin drops if you are allergic to any of its ingredients, including other quinolone antibiotics.
• Do not wear contact lenses while using the drops; wait for at least 15 minutes after application before reinserting lenses.
• Exercise caution if you have a history of tendon disorders or are taking corticosteroids, as tendon rupture is a rare but serious side effect.
• Discontinue use and seek medical attention if you experience severe skin reactions, hives, or difficulty breathing.
• Avoid using the drops for longer than prescribed, as prolonged use may lead to bacterial resistance or overgrowth of non-susceptible organisms.
• Keep the dropper tip clean and avoid touching it to any surface to prevent contamination.
• Consult a doctor if your eye infection does not improve after a few days of treatment.

Following are the drug interactions for Ofloxacin Drop:

• The use of Ofloxacin with other quinolone antibiotics or certain non-steroidal anti-inflammatory drugs (NSAIDs) can increase the risk of seizures.
• It may reduce the effectiveness of live vaccines, so vaccinations should be avoided during treatment.
• Concurrent use with theophylline may lead to increased theophylline levels and potential toxicity.
• Ofloxacin can enhance the effects of warfarin and other oral anticoagulants, requiring close monitoring of coagulation parameters.
• Taking Ofloxacin with probenecid may result in increased levels of Ofloxacin in the body.
• The absorption of Ofloxacin may be reduced when taken with antacids containing aluminum, magnesium, or calcium.
• Corticosteroid use alongside Ofloxacin may increase the risk of tendon rupture.

Following are the food interactions to consider with Ofloxacin Drops:

• Avoid consuming dairy products like milk, yogurt, or cheese within 2 hours before or after taking Ofloxacin, as calcium can interfere with the absorption of the medication.
• Caffeinated beverages such as coffee, tea, or sodas should be limited as they may increase the side effects of Ofloxacin, particularly nervous system stimulation.
• Grapefruit and grapefruit juice should be avoided as they can increase the concentration of Ofloxacin in the blood, potentially leading to increased side effects.
• Alcoholic beverages should be minimized or avoided as they can increase the risk of central nervous system side effects, such as dizziness and drowsiness.
• Consuming a high-fat meal before taking Ofloxacin may slightly delay the absorption of the medication, but it generally does not affect its overall effectiveness.
• No significant interactions have been reported with other specific foods, but maintaining a balanced diet is essential for overall health during the course of treatment.
• Always follow the dosage instructions provided by your healthcare professional, and consult them if you have any concerns about potential food interactions.

Ofloxacin Drops should be stored with caution, ensuring a cool and dry environment, preferably at room temperature, shielded from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid extreme temperatures by keeping it away from heat sources like stoves or radiators, as this can impact the medication's effectiveness. When the drops are no longer needed or have passed their expiration date, proper disposal is crucial. Do not dispose of them via the toilet or drainage systems; instead, seek guidance from a pharmacist or healthcare professional for environmentally friendly disposal methods. Lastly, ensure the medication is stored in a secure location, out of the reach of children, to prevent accidental exposure.

Following are the quick tips for Ofloxacin Drop:

• Wash your hands thoroughly before administering the drops to maintain hygiene.
• Tilt your head back slightly and gently pull down the lower eyelid to create a pocket.
• Hold the dropper close to the eye without touching it, and squeeze the prescribed number of drops into the pocket.
• Blink several times to ensure the medication spreads over the eye's surface.
• Avoid touching the dropper tip to prevent contamination.
• If you use other eye medications, wait at least 5 minutes before applying the next one.
• Store the drops at room temperature, away from direct sunlight and moisture.

Ofloxacin is a medication used to treat bacterial infections, and it falls into the category of quinolone antibiotics. While this medication is generally safe, it is essential to be aware of the potential need for lab tests during your treatment. Unless your healthcare provider advises otherwise, routine lab tests should not be required. However, it is necessary to provide your doctor with complete information about your medical history, medications you currently take, and even supplements or over-the-counter drugs you may use.Your doctor may recommend specific lab tests to monitor your health during treatment with Ofloxacin. These tests can include blood tests to monitor different blood cells and essential parameters such as kidney and liver function. Cultures and sensitivity tests can help monitor the infection's progression and the antibiotic's effectiveness. These tests also identify the bacteria causing the infection and check if they have developed resistance to the antibiotic. Regular liver function tests may also be advised in cases of prolonged use or individuals with pre-existing liver disease.It is important to understand that not all individuals taking Ofloxacin will require these tests. Your doctor will advise you on any specific tests you may need while on Ofloxacin. Disclosing all relevant information during medical consultations ensures you receive appropriate guidance and monitoring.