Febrol DS (250mg/5ml) 60ml Suspension

Paracetamol, the active ingredient in the 250mg syrup/suspension, works primarily by inhibiting the synthesis of prostaglandins in the central nervous system (CNS). It selectively blocks cyclooxygenase (COX) enzymes, particularly COX-2, in the brain and spinal cord. This action reduces the production of prostaglandin E2, which is involved in the generation and maintenance of pain signals and the regulation of body temperature. By inhibiting prostaglandin synthesis, paracetamol effectively reduces fever and relieves mild to moderate pain, making it useful for managing various conditions such as headaches, toothaches, and minor aches and pains.

Analgesic/Antipyretic

Suspension

The following are the uses of Paracetamol 250mg Syrup/Suspension:

• Used for reducing fever in children, especially when they are uncomfortable and irritable due to high body temperature.
• Used for relieving mild to moderate pain, such as headaches, toothaches, earaches, and post-vaccination pain.
• Used for managing discomfort and pain associated with common childhood illnesses like colds, flu, and sore throats.
• Used to ease the pain and discomfort of minor injuries, sprains, and strains.
• Given to manage the pain and inflammation associated with mild juvenile arthritis.
• Helps alleviate symptoms of mild to moderate pain and discomfort during growth-related aches in children.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Pain relief in adults • 2 tablets every 4-6 hours, not exceeding 8 tablets in 24 hours
• Pain relief in children (1 month to 12 years) • 5mg/kg up to a maximum of 1,000mg every 4-6 hours, not exceeding 4 dosages in 24 hours
• Reducing fever in adults • 1,000mg every 8 hours, not exceeding 3,000mg in 24 hours
• Reducing fever in children (1 month to 12 years) • 5mg/kg up to a maximum of 1,000mg every 6 hours, not exceeding 2 dosages in 24 hours

In the case of an overdose of Paracetamol 250mg Syrup/Suspension, it is important to recognize the potential severity of the situation. Initial symptoms may include nausea, vomiting, and abdominal pain, but more serious complications can develop. These can include liver damage, kidney failure, and even death if left untreated. Prompt medical attention is necessary, and individuals should seek emergency care if they suspect an overdose, especially in children or vulnerable individuals.

In the case of a missed dose of Paracetamol 250mg Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, especially if you are treating a fever or pain that requires consistent medication.

To administer Paracetamol 250mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or a measuring cup, and give it to the patient by mouth, following the dosage instructions provided by your healthcare professional, typically every 4-6 hours as needed, without exceeding the maximum daily dose.

Following are the conditions when Paracetamol 250mg Syrup/Suspension should not be used:

• Avoid in patients with severe liver or kidney impairment, as the dosage may need adjustment or alternative medication.
• Do not use if you are allergic to paracetamol or any of the excipients in the syrup/suspension.
• Not suitable for patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as it may cause hemolysis (breakdown of red blood cells).
• Contraindicated in patients with severe alcohol dependence or chronic alcohol abuse.
• Avoid using in patients with severe malnutrition or anorexia.
• Not recommended for individuals with a history of severe allergic reactions to medications.
• Should not be used if you are taking certain medications that may interact with paracetamol, such as anticoagulants (blood thinners) or carbamazepine.

The side effects of Paracetamol 250mg Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain
• Loss of appetite
• Skin rash or itching
• Dark urine (sign of liver problems)
• Yellowing of skin or eyes (jaundice)
• Allergic reactions (hives, swelling, difficulty breathing)
• Increased liver enzymes (detected in blood tests)

Following are the precautions and warnings for Paracetamol 250mg Syrup/Suspension:

• Do not exceed the recommended dosage, as Paracetamol overdose can cause severe liver damage.
• This medication should be used with caution in patients with liver or kidney impairment, as it may require dosage adjustments.
• Paracetamol may interact with other medications; inform your doctor about all the medicines you are taking.
• Avoid alcohol consumption while using this medication, as it may increase the risk of liver damage.
• Consult a doctor if you have a history of allergic reactions to Paracetamol or similar medications.
• Do not use for prolonged periods without medical supervision, especially in children and infants.
• Discontinue use and seek medical attention if you develop a skin rash, itching, or any other signs of an allergic reaction.
• Keep out of reach of children, and store in a cool, dry place.

Following are the drug interactions for Paracetamol 250mg Syrup/Suspension:

• Concomitant use with other central nervous system depressants (e.g., opioids, benzodiazepines, alcohol) can increase the risk of respiratory depression and sedation.
• Paracetamol may prolong the effects of anticoagulants like warfarin, requiring close monitoring of INR (International Normalized Ratio).
• It can potentially reduce the effectiveness of antiepileptic drugs like phenytoin and carbamazepine.
• The syrup/suspension form may contain sugars or specific sweeteners, which should be considered when used with diabetes medications.
• Caution is advised when using with other acetaminophen/paracetamol-containing products to avoid accidental overdose.
• May interact with certain HIV protease inhibitors (e.g., ritonavir) and increase the risk of liver toxicity.
• Paracetamol can increase the risk of hepatotoxicity when used with other potentially hepatotoxic drugs.

Following are the food interactions for Paracetamol 250mg Syrup/Suspension:

• Avoid excessive caffeine intake from coffee, tea, or energy drinks as it may increase the metabolism of Paracetamol, potentially reducing its effectiveness.
• Alcohol consumption should be limited as Paracetamol is primarily metabolized by the liver, and excessive alcohol can increase the risk of liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Paracetamol, potentially altering its effectiveness.
• Fatty or high-fat meals can delay the absorption of Paracetamol, which may result in a delay in pain relief.
• It is generally safe to take Paracetamol with most foods, but it is best to avoid taking it on an empty stomach to minimize the risk of stomach irritation.
• Avoid excessive consumption of foods containing high levels of tyramine, such as aged cheeses, cured meats, and fermented foods, as they may interact with Paracetamol and increase blood pressure.
• Maintain a balanced diet to support overall health while taking Paracetamol, ensuring adequate hydration and a healthy intake of fruits and vegetables.

Paracetamol 250mg Syrup/Suspension should be stored in a controlled environment, preferably at room temperature, between 20-25°C (68-77°F). Keep the bottle tightly sealed and protected from light, ensuring it remains in its original packaging to maintain its integrity. Avoid exposing the syrup to extreme temperatures or direct sunlight, as this can degrade its effectiveness. Dispose of any unused or expired medication responsibly; do not pour it down the drain or flush it, but rather follow local guidelines for pharmaceutical waste disposal. Always keep medicines out of children's reach to prevent accidental consumption, and consult a healthcare professional or pharmacist for specific disposal instructions if needed.

Following are the quick tips for Paracetamol 250mg Syrup/Suspension:

• Consult a doctor for proper dosage, especially for children and infants.
• Measure the syrup accurately using the measuring cup provided.
• Administer the syrup directly into the mouth or mix with a small amount of food or liquid if preferred.
• Ensure the child swallows the medication completely without spitting it out.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not refrigerate unless instructed by the pharmacist.
• Check the expiration date before use and discard if expired.
• Keep a record of doses given to ensure proper administration.

Paracetamol is considered generally safe when used as directed, but consumers must be made aware of its potential side effects and precautions. Caregivers and patients need to be informed that severe symptoms should be referred to medical professionals, and those exhibiting signs of hypersensitivity to the drug should avoid it altogether. Although rare, paracetamol may cause liver damage or allergy in some individuals. Therefore, it is mandatory to conduct a medical history and clinical examination of the patient before administering the drug to rule out any possibilities of adverse effects. While there are no specific laboratory tests required while taking paracetamol, it is crucial to monitor the patient's condition, and any signs or symptoms of adverse reactions should be addressed. Nevertheless, liver function tests may be necessary if the patient takes paracetamol for an extended period or consumes more than the recommended dose. These tests serve to monitor the patient's liver function and detect any signs of toxicity or damage. It is always advisable to consult a healthcare professional before taking any medication, even if it is an over-the-counter drug like paracetamol. This is especially important if you have any concerns or potential interactions with other medications. The information provided serves to promote consumer understanding and knowledge about oral paracetamol preparations. It is not intended to be comprehensive, provide medical advice, or replace the advice of a trained medical professional.