Febrol (120mg/5ml) 60ml Suspension

Paracetamol 120mg syrup/suspension primarily exerts its analgesic and antipyretic effects through central mechanisms. It acts by inhibiting the synthesis of prostaglandins, which are involved in mediating pain and inflammation. Paracetamol blocks cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system, thereby reducing the production of prostaglandin E2 (PGE2) in the brain and spinal cord. This action helps to decrease the sensitivity of pain receptors and reduces the perception of pain. Additionally, paracetamol may influence the descending serotonergic and noradrenergic pathways, which play a role in modulating pain signals in the brain.

Analgesic, antipyretic

Suspension

The following are the uses of Paracetamol 120mg Syrup/Suspension:

• Used for reducing fever and relieving mild to moderate pain, such as headaches, toothaches, and post-vaccination discomfort.
• Used for managing pain and discomfort associated with colds, flu, and sore throats.
• Used to alleviate aches and pains in children, providing a safe and effective pain relief option for younger patients.
• Used to treat mild to moderate pain from minor injuries like sprains and strains.
• Used for reducing discomfort during teething in infants and toddlers.
• Used as an adjunct therapy for pain management in certain chronic conditions under medical supervision.
• Used for symptomatic relief of pain and fever in various viral and bacterial infections.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For pain relief at bedtime for adults & elderly- Recommend dosage of 1040mg to 1280mg taken as a single dose or can be taken in 2 divided doses of 520mg to 640mg each.
• For adults with moderate to severe pain- Initially 520mg to 640mg dose taken every 4 to 6 hours, maximum dose of 3920mg per day.
• For children (2-11 years) for fever & pain- 15-20mg/kg up to a maximum of 1,000mg per dose every 4-6 hours, not to exceed 1,500mg per day.
• For adults with mild to moderate pain- Initially 520mg to 640mg dose taken every 4 to 6 hours, maximum dose of 3,120mg per day.
• For oral surgery or dentistry- Recommended single dose of 15-20mg/kg body weight, maximum 1,000mg.

In the case of an overdose of Paracetamol 120mg syrup/suspension, symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. Prompt medical attention is necessary to manage the situation effectively. Treatment may involve administering an antidote, such as acetylcysteine, to prevent or minimize liver injury. It is crucial to seek medical help immediately and provide the necessary information regarding the quantity and timing of the overdose to ensure appropriate care.

In the case of a missed dose of Paracetamol 120mg Syrup/Suspension, it is generally advised to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to get back on track with the medication schedule.

To administer Paracetamol 120mg Syrup/Suspension, shake the bottle well, use the provided measuring device to extract the prescribed dose, and administer it orally, following the dosage instructions provided by your healthcare professional, which may include frequency and duration guidelines.

Following are the conditions/situations when Paracetamol 120mg Syrup/Suspension should not be used:

• Do not use if the patient is allergic to paracetamol or any of the excipients in the syrup/suspension.
• Avoid in patients with severe liver disease or acute liver failure.
• Not recommended for individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Do not administer if the patient has a history of severe kidney impairment.
• Contraindicated in patients who have shown hypersensitivity or severe reactions to other analgesics or antipyretics.
• Should not be used in patients with inherited metabolic disorders affecting the liver.
• Not suitable for individuals who have consumed alcohol excessively or chronically.

The side effects of Paracetamol 120mg Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Loss of appetite
• Skin rash or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Liver problems (in rare cases)
• Increased sweating
• Unusual bleeding or bruising

Following are the precautions and warnings for Paracetamol 120mg Syrup/Suspension:

• This medication should not be used in patients with liver disease or severe kidney impairment without medical supervision.
• Paracetamol can cause liver damage if taken in high doses or for extended periods. Do not exceed the recommended dosage and duration.
• Alcohol consumption should be avoided while taking this medication as it may increase the risk of liver damage.
• If symptoms persist or worsen after a few days of treatment, consult a healthcare professional.
• Do not use this medication in children under 3 months of age without medical advice.
• For young children, ensure accurate measurement of the dose using the provided measuring device or as directed by a healthcare provider.
• If you are taking other medications, inform your doctor or pharmacist to avoid potential drug interactions.

Following are the drug interactions for Paracetamol 120mg Syrup/Suspension:

• When taken with other central nervous system depressants like opioids or benzodiazepines, it can increase the risk of respiratory depression and sedation.
• May reduce the effectiveness of anticonvulsant medications, leading to potential seizures.
• Paracetamol can prolong the effects of warfarin and other anticoagulants, requiring careful monitoring of blood clotting parameters.
• The risk of liver damage is increased when combined with other potentially hepatotoxic drugs, such as certain antibiotics and alcohol.
• May interact with certain anti-diabetic medications, affecting blood sugar control.
• Can affect the metabolism of other drugs processed by the liver, including some antidepressants and antiepileptic medications.
• Caution is advised when using Paracetamol with other medications that can cause kidney damage, as it may increase the risk of renal toxicity.

Following are the food interactions for Paracetamol 120mg Syrup/Suspension:

• Avoid excessive caffeine intake as it can potentially reduce the effectiveness of Paracetamol.
• Grapefruit and grapefruit juice should be consumed cautiously as they may affect the metabolism of Paracetamol, leading to higher levels in the body and increasing the risk of liver-related side effects.
• Alcohol consumption should be limited as it can increase the risk of liver damage, especially when combined with Paracetamol.
• High-fat meals may delay the absorption of Paracetamol, potentially affecting its onset of action.
• Avoid consuming large amounts of foods rich in vitamin K (like leafy greens) as Paracetamol can interfere with blood clotting, and vitamin K plays a role in this process.
• While not a food, it's important to note that prolonged use of Paracetamol may reduce the effectiveness of the medication over time.
• No significant interactions have been reported with specific foods, but always follow healthcare provider's instructions for optimal results.
• Maintain a balanced diet to support overall health while taking Paracetamol.

Paracetamol 120mg Syrup/Suspension should be stored in a secure location, preferably in a cool and dry area at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid placing it in high-temperature environments like near stoves or inside bathrooms due to the humidity. Regularly check the expiration date, and if the syrup is past its prime or no longer needed, do not flush it or pour it down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods. It is crucial to store this medication away from children to prevent accidental consumption.

Following are the quick tips for Paracetamol 120mg Syrup/Suspension:

• Consult a healthcare professional for the correct dosage, especially for children and infants.
• Measure the syrup accurately using the measuring cup provided.
• Administer the syrup directly into the child's mouth or mix with a small amount of food or drink if preferred.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Check the expiration date before use and discard if expired.
• Do not use if the syrup changes color, becomes cloudy, or develops an unusual odor.
• Seek medical advice if symptoms persist or worsen despite using the syrup.

Paracetamol is a safe drug with many benefits when taken correctly, but it can cause serious side effects such as anemia, liver damage, and kidney dysfunction. These can be exacerbated by interactions with other drugs or overdoses. For this reason, it is important to consult a doctor before taking Paracetamol. Doctors may prescribe safe usage of the drug and recommend regular lab tests to monitor health. These tests include blood count, liver function tests, kidney function tests, and blood chemistry. They will help identify any potential issues and assure the safety of the patient when taking Paracetamol. It is important to note that not all individuals taking Paracetamol will require these tests. The necessity of these tests depends on individual factors such as health condition, age, and other relevant factors. Consulting with a licensed professional is advisable to receive tailored advice and guidance.