Folace 30 Tablets

Vitamin B12, also known as cobalamin, plays a crucial role in DNA synthesis, red blood cell formation, and nervous system function. Its mechanism of action involves serving as a coenzyme in various metabolic reactions. Vitamin B12 is essential for the conversion of homocysteine to methionine, a process that requires the presence of L-methylfolate (the biologically active form of folic acid) as a methyl donor. In this reaction, Vitamin B12 acts as a cofactor for the enzyme methionine synthase, facilitating the transfer of a methyl group from L-methylfolate to homocysteine, resulting in the formation of methionine. This process is vital for maintaining proper DNA methylation and the production of S-adenosylmethionine (SAM), a universal methyl donor involved in numerous biochemical reactions in the body.

Vitamin B12 and Folate (vitamin B9)

Tablet

The following are the uses of Vitamin B 12, L-Methylfolate Tablet:

• Used for maintaining healthy nerve cells and preventing nerve damage.
• Used for treating vitamin B12 deficiency and associated symptoms like fatigue and weakness.
• Used for supporting brain health and cognitive function, improving memory and focus.
• Used for enhancing energy levels and reducing tiredness by aiding in red blood cell production.
• Used for promoting healthy skin, hair, and nails, as it plays a role in cell growth and regeneration.
• Used for supporting cardiovascular health by regulating homocysteine levels, reducing heart disease risk.
• Used for assisting in the metabolism of proteins and fats, ensuring proper digestion and nutrient absorption.
• Used for managing certain mental health conditions, such as depression, as it plays a role in neurotransmitter synthesis.

To be taken as per doctor's prescription

In the case of an overdose of Vitamin B12 and L-Methylfolate Tablets, symptoms may include nausea, dizziness, headache, and diarrhea. Excessive intake of Vitamin B12 can lead to skin rashes, itching, and anxiety. L-Methylfolate overdose may cause insomnia, confusion, and irritability. If you suspect an overdose, contact a healthcare professional or poison control center for guidance. Prompt medical advice is recommended to address any potential adverse effects.

In the case of a missed dose of Vitamin B12 and L-Methylfolate tablets, it is important to take the dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for guidance on how to resume your medication regimen safely. It is generally best to take the missed dose as soon as possible to maintain consistent nutrient levels.

To take the Vitamin B12, L-Methylfolate Tablet, place the tablet on your tongue and allow it to dissolve, preferably at the same time each day. You can take it with or without food, but maintaining consistency in timing will ensure optimal absorption. Always follow the dosage instructions provided by your healthcare professional or as indicated on the prescription label.

Here are the conditions and situations when Vitamin B12 and L-Methylfolate tablets should not be used:

• Do not take if you have a known allergy to any B vitamins or methylfolate.
• Avoid if you have a history of anemia caused by vitamin B12 deficiency and have not been treated for neurological complications.
• Not suitable for individuals with pernicious anemia.
• Should not be used as a substitute for cyanocobalamin therapy in patients with vitamin B12 deficiency.
• Do not exceed the recommended dosage, as high doses of methylfolate may cause adverse effects.
• Avoid if you have a rare genetic disorder called methylenetetrahydrofolate reductase (MTHFR) deficiency.
• Not recommended for individuals with untreated vitamin B12 deficiency.
• Discontinue use if you experience any allergic reactions or skin rashes.
• Should not be used as a sole treatment for depression without addressing other underlying causes.

The side effects of Vitamin B12 and L-Methylfolate Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Loss of appetite
• Headaches or dizziness
• Skin rashes or itching
• Nervousness or anxiety
• Sleep disturbances
• Mild itching or a tingling sensation

Here are the precautions and warnings for Vitamin B12, L-Methylfolate Tablet:

• Individuals with a known allergy to Vitamin B12 (cyanocobalamin) or L-Methylfolate should not take this medication.
• Patients with kidney disease or a history of kidney problems should exercise caution and consult a healthcare professional, as dosage adjustments might be necessary.
• This medication may cause dizziness; caution should be exercised when performing tasks that require alertness, such as driving or operating machinery.
• Alcohol consumption should be avoided or limited while taking this medication, as it may increase the risk of certain side effects.
• Patients with anemia or other blood disorders should use this medication under medical supervision, as it may mask the symptoms of these conditions.
• Elderly individuals may be more sensitive to the effects of this medication and should be monitored closely for any adverse reactions.
• If you are pregnant or breastfeeding, consult your doctor before taking this medication, as the risks and benefits should be carefully considered.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for Vitamin B12, L-Methylfolate Tablet:

• Antacids containing aluminum and magnesium may decrease the absorption of Vitamin B12. Separate the doses by 2-3 hours.
• Proton pump inhibitors and H2-receptor antagonists can reduce Vitamin B12 absorption. Monitor B12 levels during long-term use.
• Methotrexate may decrease the effects of L-Methylfolate. Consider alternative therapies or adjust doses.
• Levodopa may interact with Vitamin B12, potentially reducing its effectiveness. Close monitoring is advised.
• Phenytoin, phenobarbital, and primidone can decrease serum folate levels. Regular monitoring is recommended.
• Alcohol can interfere with folate metabolism and absorption, potentially reducing the effectiveness of L-Methylfolate.
• Folic acid supplements may interfere with the absorption of L-Methylfolate, as they compete for the same receptors.

Following are the food interactions for Vitamin B12, L-Methylfolate Tablet:

• Avoid excessive consumption of alcohol as it can interfere with the absorption of Vitamin B12 and may increase the risk of gastrointestinal side effects.
• Limit your intake of high-dose folic acid supplements, as high levels of folic acid can mask a Vitamin B12 deficiency, potentially leading to neurological issues.
• Folate-rich foods like leafy green vegetables, legumes, and citrus fruits can enhance the effectiveness of L-Methylfolate.
• Vitamin C-rich foods like citrus fruits, bell peppers, and broccoli can improve iron absorption, which is essential for proper red blood cell formation.
• Avoid consuming large amounts of raw eggs as they contain an enzyme called avidin, which can bind to Vitamin B7 (biotin) and affect its absorption.
• Limit your intake of processed foods and refined sugars, as these can deplete B vitamins and potentially interfere with the effectiveness of the medication.
• Caffeine-rich beverages should be consumed in moderation as they may interfere with the absorption of B vitamins and potentially increase nervous system stimulation.
• Ensure a balanced diet with a variety of whole grains, lean proteins, and fresh produce to support the overall effectiveness of the medication.

Vitamin B-12, L-Methylfolate Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. Do not store them in bathrooms or near heat-emitting appliances to prevent degradation. Regularly check the expiration date, and dispose of expired or unused tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist for safe disposal practices, and keep the medication away from children to prevent accidental ingestion.

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Following are the quick tips for Vitamin B12, L-Methylfolate Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a full glass of water, preferably in the morning.
• Avoid crushing, chewing, or breaking the tablet for optimal absorption.
• Maintain a consistent routine by taking it at the same time each day.
• Ensure you complete the full course as prescribed, even if you feel better.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Consult your doctor if you have any specific medical conditions or are taking other medications.