Genticyn (0.10%) 10g Cream

Gentamicin cream's mechanism of action primarily involves its role as an aminoglycoside antibiotic. When applied topically, gentamicin disrupts protein synthesis in susceptible bacteria, leading to bacterial growth inhibition or cell death. It achieves this by binding to the 30S subunit of bacterial ribosomes, causing misreading of tRNA, inhibiting translocation, and ultimately preventing the formation of essential proteins necessary for bacterial survival. This highly specific action makes gentamicin effective against a range of gram-negative bacteria, particularly those causing skin and soft tissue infections. The topical application allows for direct delivery of the antibiotic to the site of infection, minimizing systemic exposure and reducing the risk of side effects associated with oral or intravenous administration.

Gentamicin

Aminoglycoside antibiotic.

Cream

The following are the uses of Gentamicin Cream:

• Used for treating bacterial skin infections like cellulitis or folliculitis.
• Used for controlling bacteria in skin conditions like eczema or psoriasis.
• Used for preventing infection in minor cuts, scrapes, and burns.
• Used for reducing the risk of infection post-surgery or after skin procedures.
• Used for managing skin infections in patients with weakened immune systems.
• Used for improving skin health in diabetic patients with skin complications.
• Used for soothing and healing infected insect bites or wounds.
• Used for clearing up superficial skin abscesses or boils.

To be taken as per doctor's prescription

In the case of an overdose of Gentamicin Cream, it is important to act promptly. The severity of symptoms may vary depending on the amount applied. Potential effects could include skin irritation, redness, and increased sensitivity at the application site. In the event of an overdose, thoroughly wash the affected area with water and seek medical advice. Prompt action and consultation with a healthcare professional are essential steps to take in such situations.

In the case of a missed dose of Gentamicin Cream, it is important to apply the cream as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your treatment plan and ensure the medication's effectiveness. It is crucial to maintain a consistent application routine for optimal results.

To apply Gentamicin Cream, clean and dry the affected skin area, then gently massage a small amount of the cream onto the skin, ensuring complete coverage, following the dosage instructions provided by your healthcare provider or as directed on the prescription label.

Following are the conditions/situations when Gentamicin Cream should not be used:

• Avoid using Gentamicin Cream if you have a known allergy or sensitivity to gentamicin or any other aminoglycoside antibiotics.
• Do not use it if you have a history of hypersensitivity reactions to any of its ingredients.
• Not suitable for individuals with a ruptured eardrum (in the case of ear infections).
• Avoid using it on severely burned or damaged skin.
• Do not apply near the eyes, mouth, or open wounds unless directed by a healthcare professional.
• Should not be used for extended periods without medical supervision, as prolonged use may lead to bacterial resistance.
• Not recommended for individuals with a history of kidney disease or impairment.
• Avoid using it on infants or very young children without medical advice.

The side effects of Gentamicin Cream may include:

• Skin irritation at the application site
• Redness or rash
• Itching or burning sensation
• Dryness of the skin
• Swelling or inflammation
• Allergic reactions (skin redness, hives, itching)
• Skin peeling or blistering
• Hearing loss or ringing in the ears (in rare cases)

Following are the precautions and warnings for Gentamicin Cream:

• Avoid contact with eyes, ears, nose, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Gentamicin Cream is for external use only. Do not ingest or apply to open wounds.
• Do not use the cream if you are allergic to gentamicin or any other ingredients in the formulation.
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Discontinue use if sensitization or irritation occurs.
• Use with caution in patients with pre-existing kidney problems as it can affect renal function. Regular monitoring is advised.
• Avoid using other topical medications or products without medical advice in the area being treated.
• Keep out of reach of children. Store at room temperature, away from direct sunlight and moisture.
• Consult a healthcare professional if symptoms persist or worsen despite treatment.

Following are the drug interactions for Gentamicin Cream:

• Gentamicin Cream may interact with other nephrotoxic drugs (e.g., nonsteroidal anti-inflammatory drugs [NSAIDs], ACE inhibitors), increasing the risk of kidney damage when used together.
• Using Gentamicin Cream with other aminoglycoside antibiotics (e.g., amikacin, tobramycin) can increase the risk of ototoxicity (damage to the ears) and nephrotoxicity, especially with prolonged use.
• Caution is advised when using Gentamicin Cream with diuretics (e.g., furosemide) as this combination may increase the risk of kidney toxicity.
• Gentamicin Cream may interact with other topical antibiotics, potentially reducing their effectiveness or causing skin irritation.
• Combining Gentamicin with neuromuscular blockers (e.g., pancuronium) may enhance the muscle-relaxing effects, potentially leading to respiratory depression or paralysis.
• Concurrent use with other drugs that affect kidney function (e.g., certain antifungals, antivirals) may increase the risk of renal damage, requiring close monitoring of kidney function.
• When used on extensive areas of skin or broken skin, Gentamicin Cream may lead to increased absorption of the drug, heightening the risk of systemic side effects, especially if used with other medications affecting the kidneys or nervous system.

Following are the food interactions to be mindful of when using Gentamicin Cream:

• Gentamicin Cream should be avoided with citrus fruits like grapefruit and oranges, as these may increase the drug's absorption and lead to higher concentrations in the blood.
• Dairy products, especially milk, can interact with Gentamicin, reducing its effectiveness. It's best to separate milk consumption from the application of the cream by a few hours.
• Avoid excessive salt intake while using Gentamicin Cream, as high sodium levels can interfere with the medication's effectiveness.
• Alcoholic beverages might increase skin sensitivity, so it's advisable to limit alcohol consumption during the treatment period.
• Certain protein-rich foods like red meat and eggs may enhance the metabolism of Gentamicin, potentially reducing its therapeutic effect.
• Green leafy vegetables rich in vitamin K can interact with Gentamicin, affecting its antibacterial action. Consider consulting a healthcare professional for dietary advice.
• Caffeinated drinks might enhance the absorption of Gentamicin, leading to increased skin sensitivity.
• Sugary foods and beverages can affect the skin's pH, potentially reducing the effectiveness of Gentamicin Cream.

Gentamicin Cream should be stored in a cool and dry area, preferably at room temperature, ensuring protection from direct sunlight and moisture. The cream's original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid high-temperature environments like bathrooms, stoves, or radiators, as these can impact the cream's stability. Dispose of any leftover or expired cream responsibly; do not flush it down the toilet or drain. Consult your pharmacist for appropriate disposal methods, and keep the medication out of children's reach to prevent accidental ingestion. Proper storage and disposal are crucial for the effectiveness and safety of Gentamicin Cream.

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Following are the quick tips for Gentamicin Cream:

• Wash your hands before and after applying the cream for good hygiene.
• Clean and dry the affected area before applying the cream.
• Apply a thin layer of the cream, gently massaging it into the skin until absorbed.
• Avoid applying the cream near your eyes, nose, mouth, or open wounds.
• Do not cover the treated area with bandages or tight clothing.
• Complete the full course of treatment, even if symptoms improve, to ensure infection clearance.
• Store the cream at room temperature, away from direct sunlight and moisture.