Genticyn (0.30% w/v) 7.5ml Eye-Ear Drops

Gentamicin, the active ingredient in Gentamicin eye drops, is an aminoglycoside antibiotic that primarily acts by inhibiting protein synthesis in susceptible bacteria. Its mechanism of action involves binding to the 30S subunit of bacterial ribosomes, leading to misreading of tRNA, inhibiting translocation, and causing the formation of faulty peptide chains. This binding is irreversible and results in the disruption of bacterial protein synthesis, ultimately leading to bacterial cell death. Gentamicin is particularly effective against a wide range of gram-negative bacteria, including Pseudomonas aeruginosa, a common cause of eye infections. By interfering with vital protein production, Gentamicin helps control and eliminate the bacteria causing the infection.

Gentamicin

Aminoglycoside antibiotic

drop

The following are the uses of Gentamicin Drop:

• Used for treating bacterial infections, particularly those affecting the eye.
• Used for controlling bacterial growth in eye injuries or post-surgery.
• Used for preventing bacterial infections in susceptible eyes.
• Used for reducing inflammation and promoting healing in eye infections.
• Used for managing bacterial conjunctivitis and keratitis.
• Used for its broad-spectrum antibacterial properties.
• Used for local application, ensuring direct delivery of the medication to the affected eye area.
• Used for providing relief from symptoms associated with eye infections.

To be taken as per doctor's prescription

In the case of an overdose of Gentamicin Drops, several symptoms may occur, including nausea, vomiting, dizziness, and hearing loss. If a person experiences these symptoms after taking an excessive amount of Gentamicin, it is important to seek medical advice promptly. The healthcare provider may recommend specific treatments to manage the overdose, such as adjusting the dosage or providing supportive care to minimize potential harm to the kidneys and other organs.

In the case of a missed dose of Gentamicin eye drops, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra drops or use more than the prescribed amount to make up for a missed dose. If you frequently miss doses, inform your healthcare provider, as they may need to adjust your dosage or provide additional guidance to ensure the medication's effectiveness.

To administer Gentamicin eye drops, gently tilt your head back, pull down your lower eyelid to create a pocket, and hold the dropper close to your eye, releasing the prescribed number of drops into the pocket while looking up.

Following are the conditions or circumstances when Gentamicin Drops should not be administered:

• Avoid using Gentamicin Drops if you have a known allergy or hypersensitivity to Gentamicin or other aminoglycoside antibiotics.
• Do not use in patients with a history of hearing loss or balance disorders (vestibular toxicity) associated with Gentamicin use.
• Contraindicated in patients with myasthenia gravis as it can worsen muscle weakness.
• Not recommended for individuals with kidney disease or impaired kidney function.
• Avoid using Gentamicin Drops if you have a condition called Parkinson's disease.
• Should not be used in infants, especially premature babies, due to the risk of kidney damage and hearing loss.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.

The side effects of Gentamicin Eye/Ear Drops may include:

• Burning or stinging sensation in the eye or ear.
• Redness or irritation at the application site.
• Itching or rash.
• Dizziness or vertigo.
• Temporary hearing loss or ringing in the ears (tinnitus).
• Nausea and vomiting.
• Earache or ear discomfort.
• Skin sensitivity reactions.

Following are the precautions and warnings for Gentamicin Eye/Ear Drops:

• Do not use if you are allergic to gentamicin or any other aminoglycoside antibiotics.
• Avoid contact with eyes and ears if not prescribed for these areas.
• Wash your hands before and after application to prevent contamination.
• Do not touch the dropper tip to any surface to maintain sterility.
• If using for an extended period, regular monitoring of kidney function and hearing tests may be required.
• Discontinue use and seek medical attention if you experience any signs of an allergic reaction, such as a rash, itching, or difficulty breathing.
• Keep out of reach of children and pets.

Following are the drug interactions for Gentamicin Drop:

• Aminoglycosides, including Gentamicin, can enhance the toxicity of muscle relaxants like tubocurarine, increasing the risk of respiratory depression.
• Use with other ototoxic or nephrotoxic drugs, such as cisplatin or vancomycin, may increase the risk of hearing loss and kidney damage.
• Gentamicin may reduce the effectiveness of live vaccines, as it can suppress the immune response.
• Loop diuretics (e.g., furosemide) and diuretics that inhibit the renin-angiotensin-aldosterone system (e.g., ACE inhibitors, angiotensin II receptor blockers) can increase the risk of nephrotoxicity when used with Gentamicin.
• The neuromuscular blocking effects of non-depolarizing agents like vecuronium can be potentiated by Gentamicin, requiring careful monitoring.
• Anticonvulsants like phenytoin can decrease Gentamicin levels, potentially reducing its effectiveness.
• Concurrent use with other nephrotoxic agents, such as amphotericin B, should be avoided or closely monitored due to the increased risk of kidney damage.

Following are the food interactions for Gentamicin Drops:

• Gentamicin Drops should not be taken with dairy products like milk or yogurt, as calcium can decrease their absorption, reducing their effectiveness.
• Avoid consuming high-fat meals as they may delay the absorption of Gentamicin, affecting the overall efficacy.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Gentamicin, potentially increasing its levels in the body.
• Alcohol consumption should be minimized as it can increase the risk of kidney damage and ototoxicity when combined with Gentamicin.
• Avoid caffeine-rich foods and beverages, as they may enhance the potential for Gentamicin-induced side effects, particularly nervous system stimulation.
• Foods rich in potassium, like bananas and oranges, should be consumed in moderation as Gentamicin may cause an increase in potassium levels.
• Maintain a balanced diet and ensure adequate hydration to support overall kidney health during Gentamicin therapy.
• Certain herbal supplements, like Ginseng, may interact with Gentamicin, so it's best to consult a healthcare provider before using them together.

Gentamicin Eye/Ear Drops should be stored in a clean, dry area at room temperature, typically between 68°F and 77°F (20°C and 25°C). Protect the drops from direct sunlight and heat, and keep them in their original container to maintain their integrity. It is crucial to dispose of any leftover or expired medication properly; do not pour it down the drain or flush it. Contact your pharmacist or healthcare professional for appropriate disposal instructions. Keep the medication out of children's reach to prevent accidental exposure, as it is intended for external use only. Regularly check the expiration date, and do not use the drops if they appear discolored or contain particles.

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Following are the quick tips for Gentamicin Drop:

• Wash your hands thoroughly before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down the lower eyelid, and instill the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Close your eye gently and apply light pressure to the inner corner of the eye for a few seconds to minimize drug loss.
• If using other eye medications, wait at least 5 minutes between applying different eye drops to prevent washout.
• Do not wear contact lenses while using the drops unless advised by your doctor.
• Store the eye drops at room temperature, away from direct sunlight and moisture.