Glio (2mg) 20 Tablets

Glimepiride, a sulfonylurea derivative, primarily acts by stimulating insulin release from pancreatic beta cells. It selectively binds to sulfonylurea receptor 1 (SUR1) subunits of the ATP-sensitive potassium (KATP) channels on the beta-cell membrane. This binding promotes channel closure, leading to membrane depolarization, calcium influx, and subsequent insulin secretion. This mechanism is crucial in lowering blood glucose levels, as the released insulin enhances peripheral glucose uptake and utilization, while also inhibiting glucose production in the liver.

Glimepiride 2mg

Sulfonylurea.

Tablet

The following are the uses of Glimepiride 2mg Tablet:

• Used for controlling blood sugar levels in type 2 diabetes mellitus.
• Used to improve glucose tolerance and reduce insulin resistance.
• Used to manage diabetes when diet and exercise alone are not sufficient.
• Used to stimulate the release of insulin from the pancreas.
• Used for long-term management, often in combination with other diabetes medications.
• Used to help prevent diabetes-related complications.
• Used to enhance insulin sensitivity, especially in patients with stable coronary artery disease.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Managing type 2 diabetes Dosage 2.5-10mg before each meal (a maximum of 30mg per day)
• Treating glaucoma Initial dosage 0.5-1mg once a day in the morning Maximum dosage 4mg per day

In the case of an overdose of Glimepiride 2mg Tablets, it is important to recognize the potential severity of this situation. Symptoms may include severe hypoglycemia, with signs such as excessive sweating, trembling, and confusion. Immediate action is required, including administering glucose orally or intravenously. Prompt medical intervention is necessary to manage the overdose effectively and prevent potential complications. Timely response and appropriate treatment are crucial to ensuring the patient's well-being.

In the case of a missed dose of Glimepiride 2mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, as they may recommend adjusting your dosage or provide specific instructions for catching up on missed doses safely.

To take Glimepiride 2mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare provider, typically before breakfast or the first main meal of the day.

Here are the conditions or situations when Glimepiride 2mg Tablet should not be taken:

• Avoid if you are allergic to glimepiride or any similar sulfonylurea medications.
• Do not use if you have type 1 diabetes mellitus or diabetic ketoacidosis.
• Contraindicated in individuals with severe kidney or liver disease.
• Should not be taken if you are breastfeeding, as it can pass into breast milk.
• Not recommended for individuals with known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Avoid if you have a severe infection, serious injury, or are experiencing surgery and related stress.
• Do not use if you have a history of a serious allergic reaction (angioedema) to other sulfonylurea medications.
• Glimepiride should not be used if you have a condition called porphyria.
• Not suitable for individuals with an impaired liver or kidney function, or those undergoing dialysis.

The side effects of Glimepiride 2mg Tablet may include:

• Low blood sugar (hypoglycemia)
• Weight gain
• Dizziness or lightheadedness
• Nausea and vomiting
• Stomach pain or upset
• Diarrhea or constipation
• Skin rash or itching
• Fatigue or weakness

Following are the precautions and warnings for Glimepiride 2mg Tablet:

• This medication should not be initiated in patients with type 1 diabetes or diabetic ketoacidosis, and caution is advised for patients with a history of liver or kidney impairment.
• Regular monitoring of liver and kidney function is recommended during treatment.
• Patients should be advised to take the tablet before breakfast or the first main meal of the day.
• It may cause hypoglycemia (low blood sugar), especially in fasting conditions, and patients should be educated on recognizing and managing hypoglycemic episodes.
• Elderly patients may be more susceptible to hypoglycemic effects, and dosage adjustments might be necessary.
• Caution is advised when administering Glimepiride with other medications known to lower blood sugar, as it may increase the risk of hypoglycemia.
• Patients should be informed about the symptoms of hypoglycemia and advised to carry glucose tablets or another source of sugar to treat low blood sugar.
• Women who are pregnant or breastfeeding should consult their doctor before taking this medication, as it may not be suitable during these periods.

Following are the drug interactions for Glimepiride 2mg Tablet:

• Alcohol intake may cause excessive blood sugar lowering and impaired alertness.
• Glimepiride may increase the risk of hypoglycemia when used with other anti-diabetic medications like metformin, insulin, or sulfonylureas.
• Drugs that affect liver enzymes, such as rifampicin, can alter the metabolism of glimepiride.
• NSAIDs (e.g., ibuprofen) and corticosteroids may reduce the blood sugar-lowering effect of glimepiride.
• Beta-blockers and ACE inhibitors may mask the symptoms of hypoglycemia, making it harder to detect.
• Octreotide and lanreotide can increase blood glucose levels, requiring close monitoring of blood sugar.
• Drugs that affect the central nervous system, like benzodiazepines, may enhance the effects of hypoglycemia.

Following are the food interactions to consider with Glimepiride 2mg Tablet:

• Alcohol consumption should be avoided or limited as it can increase the risk of hypoglycemia and may interfere with blood sugar control.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Glimepiride, potentially leading to increased drug levels and a higher risk of hypoglycemia.
• High-fiber foods like whole grains, legumes, and certain vegetables can slow down the absorption of Glimepiride, affecting its effectiveness. Time your meals and medication accordingly.
• Fatty meals can delay the absorption of Glimepiride, potentially affecting its onset of action.
• Consuming large amounts of garlic may increase the risk of bleeding due to its antiplatelet properties, especially if you are already taking blood thinners.
• Caffeine may influence blood sugar levels and interact with Glimepiride. Monitor your blood sugar levels when consuming caffeinated beverages.
• Always ensure a consistent carbohydrate intake to maintain stable blood sugar levels, especially when taking Glimepiride.
• Follow the dietary guidelines provided by your healthcare provider to manage your blood sugar effectively while taking Glimepiride.

Glimepiride 2mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to keep the tablets away from contaminants and maintain their integrity. Avoid exposing the medication to high temperatures or freezing conditions, as this can impact its effectiveness. When disposing of unused or expired tablets, it is crucial not to flush them down the toilet or dispose of them in household waste. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe and environmentally friendly disposal methods. Keep the medication securely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Glimepiride 2mg Tablet:

• Take the tablet as directed by your doctor, typically with breakfast or the first main meal of the day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent meal schedule, as the medication is most effective when taken with food.
• Monitor your blood sugar regularly and inform your doctor of any significant changes.
• Avoid alcohol consumption as it can lower blood sugar levels and interact with the medication.
• Inform your doctor about all medications/supplements you are taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.

When taking glimepiride, it is important to monitor one's health to ensure that the medication is effective and safe. Glycosylated Hemoglobin tests should be taken periodically to monitor blood sugar levels. This test helps your doctor assess how well your diabetes is controlled by glimepiride. Fasting Blood Sugar Level Tests, on the other hand, measure your blood sugar concentration after an 8-hour fast and help diagnose diabetes mellitus. Postprandial Blood Sugar Tests measure blood sugar levels 2 hours after a meal, important for diagnosing glucose intolerance or diabetes. However, one's cholesterol and triglyceride levels, which are important for assessing cardiovascular disease risk, are not ignored. Kidney Function Tests, nonetheless, are critical for monitoring kidney function and the balance of sodium, potassium, and calcium levels due to the risk of glimepiride-induced dehydration. Similarly, Liver Function Tests look for any abnormalities in liver function and can help diagnose non-glimepiride-related liver diseases or disorders. In conclusion, periodic laboratory testing is essential to ensuring that glimepiride use is safe and effective, as well as to monitor for any diabetes-related complications.