Inosita (50mg) 28 Tablets

Sitagliptin, a medication commonly found in 50mg tablets, exerts its therapeutic effect by selectively inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This enzyme is responsible for breaking down incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which play a crucial role in regulating blood glucose levels. By inhibiting DPP-4, sitagliptin prolongs the action of these incretin hormones, leading to enhanced insulin secretion in response to elevated blood glucose levels. This mechanism helps to lower blood glucose levels in individuals with type 2 diabetes, primarily by promoting insulin release and reducing the rate of glucagon secretion from the pancreas.

DPP-4 inhibitor

Tablet

The following are the uses of Sitagliptin 50mg Tablet:

• Used for treating type 2 diabetes, helping lower blood sugar levels.
• Used to improve glycemic control and reduce the risk of diabetes-related complications.
• Used to enhance insulin production and reduce the rate of glucose production in the body.
• Used to manage blood sugar, especially when combined with proper diet and exercise.
• Used to help reduce A1C levels, a measure of long-term blood sugar control.
• Used to improve insulin sensitivity and promote better glucose metabolism.
• Used to potentially delay the progression of prediabetes to type 2 diabetes.
• Used as part of a comprehensive diabetes management plan to improve overall health.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Diabetes- It is recommended to take 50mg once daily with a meal to maximise blood sugar control. If you miss a dose, take it if it has been less than 12 hours since your last dose. If it has been more than 12 hours, you can skip the missed dose and return to your regular dosing schedule. It is essential to have a healthy diet and regular exercise and to check your blood sugar levels as advised by your healthcare provider.
• Kidney Disease- For adults with renal impairment, the recommended dose of Sitagliptin is 50mg once daily. Your doctor may adjust your dosage if you have severe kidney issues or if you are undergoing dialysis.
• Liver Disease- If you have moderate to severe liver disease, your starting dose of Sitagliptin may be lowered to 25mg once daily to lessen the risk of drug accumulation in the body.
• Weight Loss- Sitagliptin is not specifically approved for weight loss, but it helps control blood sugar levels and reduces the risk of complications related to diabetes.
• Heart Disease- If you have heart disease, your treatment plan will involve multiple strategies tailored to your specific condition. Besides medical therapy, adopting a healthy lifestyle and addressing underlying risk factors are essential.
• Elderly Population- Elderly individuals with type 2 diabetes tend to be more susceptible to the drug's side effects, especially if they are already taking other medications. Therefore, it is essential to closely monitor elderly patients for adverse effects.

In the case of an overdose of Sitagliptin 50mg Tablets, individuals may experience severe hypoglycemia, characterized by symptoms such as dizziness, sweating, confusion, and rapid heartbeat. Prompt medical intervention is necessary to manage the overdose effectively. Treatment may involve administering intravenous glucose solutions to stabilize blood sugar levels and providing supportive care to address any associated symptoms. It is crucial to contact healthcare professionals or poison control centers for guidance on managing the overdose appropriately.

In the case of a missed dose of Sitagliptin 50mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to get back on track with your medication regimen. It is crucial to maintain a consistent routine with this medication for optimal effectiveness.

To take Sitagliptin 50mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the instructions provided by your healthcare professional, usually once daily with or without food.

Here are the conditions or situations when Sitagliptin 50mg Tablet should not be used:

• Do not take if you are allergic to Sitagliptin or any other DPP-4 inhibitor drugs.
• Avoid if you have a history of pancreatitis (inflammation of the pancreas).
• Not recommended for individuals with type 1 diabetes or diabetic ketoacidosis.
• Should not be used alone to treat type 2 diabetes if blood sugar is significantly high.
• Contraindicated in patients with severe kidney problems or end-stage renal disease.
• Not suitable for those who are breastfeeding, as it may pass into breast milk.
• Exercise caution if you have a history of kidney stones or gallstones.

The side effects of Sitagliptin 50mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Headache
• Dizziness
• Fatigue and weakness
• Skin rash or itching
• Upper respiratory tract infection

Following are the precautions and warnings for Sitagliptin 50mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Sitagliptin or any of its ingredients.
• Patients with a history of pancreatitis should exercise caution and inform their healthcare provider, as Sitagliptin may increase the risk of pancreatitis.
• Regular monitoring of kidney function is advised, especially in patients with a history of kidney disease, as Sitagliptin is primarily eliminated through the kidneys.
• Caution is warranted in patients with type 1 diabetes or diabetic ketoacidosis, as Sitagliptin is not recommended for these conditions.
• Patients should be aware of the potential risk of severe joint pain and discontinue the medication if this occurs, seeking medical advice promptly.
• It may cause dizziness or blurred vision; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Pregnant and breastfeeding women should consult their doctor before taking Sitagliptin, as the potential risks and benefits should be carefully considered.
• This medication should be used with caution in the elderly, as they may be more susceptible to certain side effects.

Following are the drug interactions for Sitagliptin 50mg Tablet:

• Sulfonylureas or insulin, when combined with Sitagliptin, may increase the risk of hypoglycemia, requiring careful monitoring of blood glucose levels.
• Thiazolidinediones, if used with Sitagliptin, can cause fluid retention and an increased risk of heart failure.
• The risk of kidney function impairment may increase when Sitagliptin is used with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs).
• When Sitagliptin is taken with digoxin, it may increase digoxin levels, requiring close monitoring of digoxin concentrations.
• Sitagliptin may increase the blood levels of certain anti-inflammatory drugs like diclofenac, potentially increasing the risk of side effects.
• Drugs that affect renal function, when used with Sitagliptin, may alter its elimination, requiring dosage adjustments.
• The efficacy of oral contraceptives may be reduced when taken with Sitagliptin, requiring additional contraceptive measures.

Following are the food interactions for Sitagliptin 50mg Tablet:

• Alcohol intake should be limited or avoided as it can increase the risk of pancreatitis, a potential side effect of Sitagliptin.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Sitagliptin, potentially leading to increased drug levels in the body.
• Avoid high-fat meals as they can delay the absorption of Sitagliptin, resulting in reduced effectiveness.
• Caffeine-containing beverages such as coffee and tea may reduce the absorption of Sitagliptin, so it's best to consume these beverages at least an hour before or after taking the medication.
• Dairy products like milk and yogurt can decrease the absorption of Sitagliptin, so it is advisable to separate their consumption from medication intake.
• Foods rich in fiber, such as whole grains, legumes, and vegetables, may enhance the glucose-lowering effect of Sitagliptin, aiding in better blood sugar control.
• A balanced diet with a variety of fruits, vegetables, lean proteins, and whole grains is generally recommended to support overall health and diabetes management while taking Sitagliptin.
• Always follow the dietary advice provided by your healthcare professional, as individual recommendations may vary based on your specific health condition.

Sitagliptin 50mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring it is protected from light and moisture. The tablets should be kept in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store the medication in the bathroom or near heat sources, as temperature fluctuations can impact its effectiveness. Regularly check the expiration date, and if the medication is expired or no longer needed, it should be disposed of responsibly. Avoid flushing or pouring it down the drain; consult a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the tablets out of children's reach to prevent accidental consumption.

Following are the quick tips for Sitagliptin 50mg Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Consume the tablet whole with a glass of water, preferably at the same time each day.
• You can take it with or without food, but be consistent with your choice.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose; in that case, skip the missed dose and continue with your regular schedule.
• Store the medication at room temperature, away from moisture and light.
• Regularly monitor your blood sugar levels as advised by your doctor.

When taking the medication Sitagliptin, it is important to be aware that it may cause injuries to your kidneys, affect your vitamin B12 levels, and your cholesterol levels. Because of this, it is important to have regular lab tests to monitor these levels to ensure that they are within a healthy range. Should any of these values be outside of the normal range, it is important to notify your prescribing doctor so they can adjust your dosage or switch you to a different medication to prevent further issues.