Isotrate (20mg) 60 Tablets

Isosorbide, the active ingredient in the 20mg tablet, primarily exerts its therapeutic effects by relaxing smooth muscle cells within blood vessels, thereby improving blood flow. This mechanism is attributed to its ability to inhibit phosphodiesterase type 3 (PDE3), an enzyme responsible for breaking down cyclic adenosine monophosphate (cAMP). By inhibiting PDE3, isosorbide leads to an increase in intracellular cAMP levels, which, in turn, activates protein kinase A (PKA). PKA phosphorylates various target proteins, resulting in the relaxation of smooth muscle cells, vasodilation, and reduced vascular resistance. This action is particularly beneficial in conditions where improved blood flow is required, such as in the management of angina pectoris or certain vascular disorders.

Isosorbide 20mg

Nitrate vasodilator.

Tablet

The following are the uses of Isosorbide 20mg Tablet:

• Used for preventing and treating heart pain (angina).
• Used to improve exercise capability in people with heart failure.
• Used for reducing the risk of death after a recent heart attack.
• Used to lower blood pressure in people with high blood pressure (hypertension).
• Used for managing chest pain in people who cannot take other angina medications.
• Used for its vasodilator properties, helping to widen blood vessels and improve blood flow.
• Used as a long-term treatment option for maintaining heart health.

To be taken as per doctor's prescription

In the case of an overdose of Isosorbide 20mg Tablets, individuals may experience symptoms such as severe headaches, dizziness, blurred vision, and a rapid or irregular heartbeat. It is crucial to seek medical assistance promptly if you suspect an overdose. Treatment may involve monitoring vital signs, providing supportive care, and administering medications to manage specific symptoms. Prompt action can help mitigate the potentially harmful effects of an overdose.

In the case of a missed dose of Isosorbide 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice, as they may recommend adjusting your dosage or provide further instructions to ensure the medication's effectiveness.

To take Isosorbide 20mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Isosorbide 20mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Isosorbide or other nitrates.
• Contraindicated in patients with severe hypotension (very low blood pressure).
• Not suitable for individuals with head trauma or increased intracranial pressure.
• Should not be used during acute myocardial infarction (heart attack).
• Contraindicated in patients with cardiac tamponade (fluid around the heart).
• Not recommended for individuals with constrictive pericarditis (inflammation of the heart lining).
• Should not be used in patients with aortic stenosis (narrowing of the aortic valve).
• Avoid use in patients with hypertrophic obstructive cardiomyopathy (thickened heart muscle).
• Not suitable for individuals with severe anemia.
• Should be avoided in patients with recent stroke.

The side effects of Isosorbide 20mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Fatigue or weakness
• Blurred vision
• Flushing (warmth or redness of the skin)
• Stomach pain or discomfort
• Increased heart rate

Following are the precautions and warnings for Isosorbide 20mg Tablet:

• Patients with known allergies to Isosorbide or other nitrates should not take this medication.
• Blood pressure should be monitored regularly, especially in patients with low blood pressure, as the medication can cause a significant drop in blood pressure.
• Caution is advised for patients with a history of heart problems, as it may cause an irregular heartbeat or increased heart rate.
• This medication can cause dizziness and lightheadedness, so patients should rise slowly from a sitting or lying position to prevent falls.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Patients should inform their doctor if they have a history of liver or kidney disease, as dosage adjustments may be necessary.
• Isosorbide may cause headaches, and if they become severe or persistent, medical advice should be sought.
• Not recommended for use in children, and elderly patients may require lower doses.

Following are the drug interactions for Isosorbide 20mg Tablet:

• Alcohol consumption may lead to increased side effects like dizziness and low blood pressure.
• Antihypertensive medications, such as beta-blockers or ACE inhibitors, can have additive effects on blood pressure, requiring close monitoring.
• Drugs metabolized by the liver, including certain antibiotics (e.g., erythromycin) and antifungal agents, may affect Isosorbide metabolism.
• Nitrates and phosphodiesterase inhibitors (e.g., sildenafil) can have additive vasodilatory effects, potentially causing excessive blood pressure drop.
• Tricyclic antidepressants and sympathomimetic amines may counteract the effects of Isosorbide.
• The hypotensive effects of Isosorbide may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Antacids can decrease the absorption of Isosorbide, leading to reduced effectiveness.

Following are the food interactions to be aware of when taking Isosorbide 20mg Tablet:

• Avoid consuming large amounts of grapefruits or grapefruit juice as they may interfere with the breakdown of Isosorbide, leading to increased drug levels in the body.
• Alcohol consumption should be limited as it can cause excessive lowering of blood pressure, especially when combined with Isosorbide.
• Avoid high-sodium foods as sodium can counteract the effects of Isosorbide and may lead to increased blood pressure.
• Limit the intake of foods rich in potassium such as bananas, oranges, and green leafy vegetables, as Isosorbide can increase potassium levels in the body.
• Caffeine-rich foods and beverages might interact with Isosorbide, so monitor your intake of coffee, tea, and energy drinks.
• Consuming a high-fat meal may affect the absorption of Isosorbide, so it is best to take the medication on an empty stomach or with a low-fat meal.
• Avoid excessive use of herbs like St. John's Wort, as it may reduce the effectiveness of Isosorbide.
• Always stay hydrated and drink plenty of water when taking Isosorbide to maintain blood volume and support the medication's action.

Isosorbide 20mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storing it in hot areas like near stoves or inside vehicles. Always check the expiration date, and for proper disposal, do not flush or pour the medication down the drain; instead, consult a pharmacist for safe disposal methods. Keep the tablets away from children to prevent accidental consumption.

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Following are the quick tips for Isosorbide 20mg Tablet:

• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication for best results.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor if you have a history of liver or kidney disease before taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.