Jentin Met (50/1000mg) 14 Tablets

Sitagliptin is a drug used in conjunction with Metformin to help treat patients with Type 2 diabetes. It works by inhibiting the breakdown of a peptide hormone called glucagon-like peptide 1 (GLP-1) which is involved in glucose regulation. This inhibition increases insulin production in the pancreas and decreases glucose absorption in the intestine, helping to balance abnormal blood sugar levels. Metformin is often used in conjunction with Sitagliptin as it acts through a different mechanism. It reduces glucose production in the liver, reduces glucose absorption from the digestive tract, and enhances glucose uptake in muscle tissues. When taken together, Sitagliptin and Metformin work synergistically to effectively control and manage blood sugar levels in those with Type 2 diabetes who require treatment. It's crucial to remember that these medications can only be prescribed by a medical professional and any concerns about the medication should be discussed with your healthcare provider.

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Biguanide, DPP-4 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus options and details of drugs that can be administered to manage the condition
• Main recommendation is to be used with insulinogenic substances
• How to manage hyperglycemia details
• Sitagliptin works by increasing the concentration of natural substances that can lower blood glucose levels
• Metformin works by increasing glucose uptake and utilization and decreasing glucose production in the liver
• Frequency of consumption of Sitagliptin 50mg tablets - once daily
• Metformin HCl 1000 mg tablets - extended-release tablets that require once-daily consumption preferably with food

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The recommended dose of Sitagliptin for treating type 2 diabetes is 50 mg once daily.
• The recommended dose of Metformin is 1000 mg once daily.
• Always take medications as prescribed by your doctor.
• Depending on the severity of your condition, your doctor will determine the best dosage and approach to managing your disease.
• For any specific concerns, questions, or alterations in your condition, contact your medical practitioner.

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An overdose of sitagliptin and metformin can lead to numerous unpleasant symptoms such as hypoglycemia, nausea, vomiting, dizziness, and headaches. It is important to seek immediate medical attention if an overdose is experienced. Hospital staff may choose to monitor vital signs, administer glucose if necessary, and provide detoxification or different medications as required. This is done to address both the symptoms and the cause, which may stem from a variety of factors including drug intake, diet, or underlying conditions. Furthermore, medical personnel may adjust the dosage or choose to switch to alternative treatments, taking into consideration the patient’s condition, lifestyle, and medication history.

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If you have missed a dose of your medication, it is critical to take it as soon as possible. However, if it is almost time for your next scheduled dose, it is advisable to skip the missed dose and return to your regular dosing schedule. It is best not to double up on doses. Should you have any doubts or concerns, please contact your doctor or pharmacist to clarify the instructions for your medication and determine the appropriate course of action. Keeping track of any missed doses and expressing your concerns with your healthcare provider at your next appointment is also highly recommended. You should consult your doctor or pharmacist for specific advice on managing a missed dose in your particular case.

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The combination of sitagliptin and metformin should be taken orally as prescribed by a healthcare provider, typically once or twice daily with meals to reduce gastrointestinal side effects. The dose is based on the patient's current condition, renal function, and prior response to therapy.

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Discerning instances where this medication may not be appropriate:

• Existing Vitamin B12 Deficiency - Since Metformin affects the absorption of Vitamin B12, which can lead to deficiencies, individuals who are B12 deficient should not take Metformin to avoid worsening symptoms.
• Sodium-Containing Products - Metformin is known to cause sodium retention which is unsafe for individuals with certain cardiovascular conditions. Those with heart failure or who have had a recent myocardial infarction should avoid Metformin.

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Unraveling the side effects lurking behind this medications are as follows:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Weakness
• Fatigue
• Muscle pain
• Glucosamine bone pain
• Joint pain
• Itchiness
• Low blood glucose levels • Weight loss
• Belly pain

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Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

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Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels)
• Metformin and sitagliptin generally have minimal interaction with other medications, but individual patient scenarios should always be reviewed for potential interactions.

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When storing Sitagliptin 50mg and Metformin 1000mg tablets, ensure they are kept in an airtight container in a cool, dry place, away from heat and direct light. These medications should be kept out of reach of children and pets. It is important to follow the instructions on the medication label and consult a healthcare professional if you have any questions. Optimal storage methods may vary, so it is always best to consult the specific product's instructions and a healthcare professional if you have any questions. In addition, it is important to note that Metformin should be kept in an airtight container to avoid exposure to moisture, which may affect its efficacy and safety. It is also important to discard any expired or unused medication according to the instructions of a knowledgeable professional or pharmacist.

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When taking both Sitagliptin and Metformin, it is important to undergo specific lab tests to ensure the medication is working effectively and to monitor for any potential side effects. These tests are crucial for individuals taking Metformin, as the medication can affect blood sugar, ketone, kidney, and thyroid levels. The first lab test, blood sugar monitoring, is essential for individuals taking Metformin, as it is a common medication for type 2 diabetes. This test determines fasting blood sugar levels and HbA1c levels, both of which are important for monitoring the average blood sugar levels over time. Normally, fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) tests are conducted to monitor these levels. The second lab test, ketone testing, is particularly important for individuals taking Metformin, as the medication can cause lactic acidosis in rare cases. This test allows for the presence of ketones in the blood, which can be a marker for diabetic ketoacidosis. The third lab test, kidney function tests, is critical for individuals taking Metformin. This is because Metformin is excreted by the kidneys; therefore, it is important to monitor kidney function. Serum creatinine and estimated glomerular filtration rate (eGFR) tests are conducted to assess kidney function and determine if the dosage needs to be adjusted. The fourth lab test, thyroid function tests, is important for individuals taking Metformin because hypothyroidism is a potential side effect of the medication. Periodic testing of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) is recommended for early detection and management. It is imperative to never miss or skip a lab test while taking medications like Sitagliptin and Metformin. These tests help in monitoring the effectiveness of the medicines and facilitate any necessary changes to a patient's

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