Jentin-Met (50/500mg) 14 Tablets

Sitagliptin 50mg is a drug that inhibits the dipeptidyl peptidase-4 (DPP-4). It works by increasing the levels of hormones called incretins, which stimulate insulin release when blood sugar levels are high. Metformin Hydrochloride 1000mg is a biguanide-class drug that helps lower blood glucose levels. It does so by decreasing glucose absorption, improving insulin sensitivity and reducing glucose production by the liver. This medication is insulin-independent, meaning it does not rely on insulin to lower blood sugar. When used in conjunction, Sitagliptin 50mg and Metformin Hydrochloride 1000mg are able to lower serum glucose levels even more effectively than if they are used alone. This is because Sitagliptin increases the concentration of the incretin hormone GLP-1, which stimulates insulin release and decreases the presence of glucagon. Metformin works to lower glucose levels as well, and also enhances GLP-1 signaling, thereby increasing the effects of Sitagliptin. The combination of these mechanisms provides additive glucose lowering effects, making this combination an effective treatment for type-2 diabetes mellitus, helping to manage serum glucose levels.

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Biguanide, DPP-4 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Sitagliptin is used with diet and exercise in adults with type 2 diabetes who cannot control their blood sugar on metformin alone or in those who are already taking the maximum tolerated dose of metformin.
• Metformin Hydrochloride is used to manage type 2 diabetes and to reduce the risk of developing complications such as blindness, strokes, heart attacks, and kidney problems.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take Sitagliptin 50mg- Take one tablet with or without food, once a day, at the same time every day. For adequate control of diabetes, the dosage should be adjusted accordingly based on self-monitoring of blood glucose levels and clinical response. The maximum recommended dose is 100mg per day.
• Take Metformin Hydrochloride 1000mg- Take two tablets with or without food, once a day, at the same time every day
• It is important to adhere to the prescribed dosage and instructions given by your healthcare provider.

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An overdose of sitagliptin and metformin can lead to a dangerous condition called lactic acidosis, where there is a buildup of lactic acid in the blood. This condition can cause various symptoms including weakness, slow breathing, dizziness, confusion, muscle pain or cramps, nausea, slow heart rate, cold or clammy skin, convulsions, loss of consciousness, and blurry vision. If you experience any of these symptoms, it is important to seek medical attention immediately. In terms of treatment, inducing vomiting and administering activated charcoal can help to remove the toxic substances from the stomach and prevent further absorption. Fluids administered through IV can help flush the drugs out of the system and balance pH levels. Stomach pumping may also be necessary to ensure that all toxic residue is removed. Medications that reverse the effects of the overdose can also be prescribed, along with oxygen therapy to treat any breathing difficulties. In severe cases of metformin poisoning, kidney dialysis may be required. Hospitalization may be necessary for close monitoring and treatment of any ongoing symptoms. It is also vital to emphasize that you should not self-medicate or overdose on any medication, ever. It is important to note that the side effects and risks of overdose of these two drugs are manageable and rarely lead to fatalities if medical care is sought in time. However, it is essential to follow medical advice and ensure you communicate well with your healthcare provider should you be on these medications.

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If you have missed a dose of your medication, it is critical that you take it as soon as you can. If it is almost time for your next scheduled dose, it is recommended that you skip the missed dose and stick to your regular dosing schedule. It is not a good idea to double up on doses to make up for the missed one. If you are unsure about what to do, it is always best to reach out to your healthcare provider to determine the best course of action. To ensure the effective management of your health condition, it is essential to maintain a consistent dosing schedule as advised by your physician.

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The combination of sitagliptin and metformin should be taken orally as prescribed by a healthcare provider, typically once or twice daily with meals to reduce gastrointestinal side effects. The dose is based on the patient's current condition, renal function, and prior response to therapy.

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Discerning instances where this medication may not be appropriate:

• Existing Vitamin B12 Deficiency - Since Metformin affects the absorption of Vitamin B12, which can lead to deficiencies, individuals who are B12 deficient should not take Metformin to avoid worsening symptoms.
• Sodium-Containing Products - Metformin is known to cause sodium retention which is unsafe for individuals with certain cardiovascular conditions. Those with heart failure or who have had a recent myocardial infarction should avoid Metformin.

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Unraveling the side effects lurking behind this medications are as follows:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Joint pain
• Nausea
• Stomach upset
• Fatigue
• Muscle pain
• Tingling or numbness in hands and feet
• Reduced coordination
• Increased blood glucose levels
• Upper respiratory tract infection
• Diarrhea
• Vomiting
• Abdominal discomfort
• Loss of appetite
• Weight loss
• Severe muscle pain
• Slow healing wounds
• Unusual thirst or urination
• Confusion

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Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

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Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels)
• Metformin and sitagliptin generally have minimal interaction with other medications, but individual patient scenarios should always be reviewed for potential interactions.

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Sitagliptin 50mg and Metformin Hydrochloride 1000mg are important medications that should be stored in a safe and dry place at room temperature. Ensure that the medications are kept in an airtight container, away from children and pets. Physicians will provide specific guidelines for storage, and the medication label will provide any additional storage instructions specific to the medication. For any questions regarding the storage of these medications, or any other medications, it is recommended to consult with a medical professional for guidance. It is important to always follow the advice of your trusted medical professional.

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