Jezeta (10/20mg) 10 Tablets

Ezetimibe 10mg and Atorvastatin 20mg work synergistically in the Ezetimibe 10mg, Atorvastatin 20mg Tablet. Atorvastatin belongs to the statin class of drugs and acts by inhibiting the enzyme HMG-CoA reductase in the liver, which is responsible for the production of cholesterol. By blocking this enzyme, Atorvastatin reduces the liver's ability to produce cholesterol, leading to lower levels of LDL (low-density lipoprotein) cholesterol in the blood. On the other hand, Ezetimibe has a unique mechanism of action, targeting cholesterol absorption in the intestine. It selectively inhibits the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for cholesterol absorption in the gastrointestinal tract. By blocking NPC1L1, Ezetimibe reduces the uptake of dietary and biliary cholesterol, resulting in decreased cholesterol absorption and lower levels of circulating LDL cholesterol. The combined effect of these two mechanisms helps to significantly lower LDL cholesterol levels, making the tablet effective in managing dyslipidemia and reducing cardiovascular risk.

Ezetimibe 10mg, Atorvastatin 20mg

Statin and cholesterol absorption inhibitor.

Tablet

The following are the uses of Ezetimibe 10mg, Atorvastatin 20mg Tablet:

• Used for lowering high cholesterol levels, especially in patients who have not responded well to other treatments.
• Used for managing conditions like familial hypercholesterolemia, where bad cholesterol levels are significantly elevated.
• Used to reduce the risk of heart attacks, strokes, and other cardiovascular issues by controlling cholesterol.
• Used to treat high cholesterol and triglyceride levels, improving overall heart health.
• Used to prevent the absorption of cholesterol from the diet, helping to lower overall cholesterol levels.
• Used for long-term management of cholesterol levels, often in combination with lifestyle changes.
• Used to stabilize cholesterol levels and prevent the formation of fatty deposits in the arteries.

Dosage is strictly to be determined by the doctor.

In the case of an overdose of Ezetimibe 10mg and Atorvastatin 20mg tablets, individuals may experience symptoms such as muscle pain, tenderness, or weakness, as well as increased liver enzyme levels. It is important to seek medical advice promptly if a person suspects they have taken an excessive amount of these medications. Treatment for overdose may involve supportive measures, monitoring of liver function, and managing any muscle-related complications that arise. Prompt recognition and medical intervention are crucial in managing potential adverse effects.

In the case of a missed dose of Ezetimibe 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Atorvastatin 20mg Tablet, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing routine. Do not double the dose to make up for a missed one. Consult your healthcare provider if you frequently miss doses or have concerns about your medication schedule.

To take the Ezetimibe 10mg, Atorvastatin 20mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions or situations when Ezetimibe 10mg, Atorvastatin 20mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ezetimibe, Atorvastatin, or any other similar cholesterol-lowering medications.
• Contraindicated in patients with active liver disease or persistent elevations in liver enzymes.
• Not recommended for individuals with uncontrolled hypothyroidism.
• Should not be used in pregnant or breastfeeding women.
• Avoid using this medication if you have a history of unexplained muscle pain or weakness.
• Contraindicated in patients with a history of serious adverse reactions to statins.
• Not suitable for individuals with a history of alcohol abuse or heavy drinking.

The side effects of Ezetimibe 10mg, Atorvastatin 20mg Tablet may include:

• Muscle pain and weakness
• Joint pain
• Constipation or diarrhea
• Nausea and vomiting
• Increased blood sugar levels
• Liver problems (rare)
• Skin rash or itching
• Fatigue

Following are the precautions and warnings for Ezetimibe 10mg, Atorvastatin 20mg Tablet:

• Do not start or continue the medication if you are allergic to Ezetimibe, Atorvastatin, or any other similar drugs.
• Patients with liver disease should exercise caution and consult a doctor, as this medication may affect liver function.
• Regular monitoring of liver function is necessary while taking this medication.
• This medication may increase blood sugar levels, so diabetic patients should monitor their blood glucose regularly.
• It may rarely cause muscle pain and weakness, and patients should seek medical attention if they experience these symptoms.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may have potential risks.
• Keep this medication out of reach of children and pets.
• Do not share this medication with others, even if their symptoms appear similar.

Following are the drug interactions for Ezetimibe 10mg, Atorvastatin 20mg Tablet:

• Ezetimibe may increase the absorption of statins, including Atorvastatin, potentially leading to increased side effects.
• Concomitant use with other lipid-lowering agents like fibrates (e.g., gemfibrozil) can increase the risk of muscle-related side effects and rhabdomyolysis.
• Taking Ezetimibe with immunosuppressants (e.g., ciclosporin) may increase the exposure to these drugs, requiring dosage adjustments.
• The effects of anticoagulants like warfarin may be altered, requiring monitoring of coagulation parameters.
• Ezetimibe can increase the concentration of certain medications metabolized by CYP3A4, such as cyclosporine and colchicine, potentially increasing side effects.
• Caution with macrolide antibiotics (e.g., erythromycin) as they may increase Ezetimibe and Atorvastatin levels, raising the risk of adverse reactions.
• Grapefruit juice should be avoided as it can increase the plasma concentrations of Atorvastatin, potentially leading to increased side effects.

Following are the food interactions for Ezetimibe 10mg, Atorvastatin 20mg Tablet:

• Consumption of grapefruit or grapefruit juice should be avoided as it can significantly increase the blood levels of Atorvastatin, leading to an increased risk of muscle-related side effects.
• Limit alcohol intake as it can increase the risk of liver-related issues when combined with Atorvastatin.
• Avoid high-fat meals, as they can increase the absorption of Ezetimibe, potentially leading to increased side effects.
• Dairy products, particularly those high in fat, may reduce the absorption of Ezetimibe. Consider separating dairy intake from medication by a few hours.
• Avoid eating large amounts of fiber-rich foods simultaneously with Ezetimibe, as fiber may interfere with its absorption.
• Do not consume Seville oranges or products containing them, as they can affect the metabolism of Atorvastatin.
• Be cautious with vitamin supplements, especially those containing beta-carotene, as Atorvastatin may increase beta-carotene levels in the body.

Ezetimibe 10mg, Atorvastatin 20mg tablets should be stored in a cool and dry place, preferably at room temperature (around 25°C) inside a medicine cabinet or a storage box. Keep the tablets in their original packaging, ensuring the container is tightly sealed to protect them from moisture and light. It's crucial not to expose the medication to extreme temperatures, so avoid storing it in the refrigerator, freezer, or near heat sources like ovens or heaters. Always check the expiration date, and do not use the tablets if they are past their expiry. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult a pharmacist for safe disposal options, ensuring they are kept away from children and pets.

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Following are the quick tips for Ezetimibe 10mg, Atorvastatin 20mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablet whole; do not crush, chew, or break it.
• Take the tablet at the same time each day to maintain consistent blood levels.
• It can be taken with or without food, but taking it with a meal can reduce the risk of stomach upset.
• Inform your doctor about all medications you are currently taking to avoid potential drug interactions.
• Do not stop taking the medication abruptly; consult your doctor for a proper tapering plan.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.