Ketro (0.5%) 5ml Eye Drops

Ketorolac tromethamine, a non-steroidal anti-inflammatory drug (NSAID), exerts its analgesic and anti-inflammatory effects through the inhibition of prostaglandin synthesis. It primarily targets cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are crucial in the production of prostaglandins. By blocking these enzymes, ketorolac tromethamine reduces the formation of inflammatory mediators, thereby alleviating pain and inflammation. This mechanism of action is particularly effective in managing postoperative ocular pain and reducing ocular pruritus associated with allergic conjunctivitis.

Ketorolac Tromethamine

Nonsteroidal anti-inflammatory drug (NSAID)

Drop

The following are the uses of Ketorolac Tromethamine Drop:

• Used for relieving eye itching and reducing eye redness caused by seasonal allergies.
• Used for treating pain and inflammation after eye surgery.
• Used for reducing swelling and irritation in the eye.
• Used for managing eye pain and discomfort due to minor injuries or irritants.
• Used for treating inflammation and pain associated with eye conditions like uveitis.
• Used for alleviating eye discomfort and irritation caused by contact lens wear.
• Used for controlling eye inflammation and pain in certain eye diseases.

To be used as per doctor's advice

In the case of an overdose of Ketorolac Tromethamine Drops, it is important to act swiftly. Symptoms may include severe drowsiness, confusion, and gastrointestinal bleeding. Promptly seek medical assistance and inform healthcare professionals about the suspected overdose. They will provide necessary guidance and treatment to manage the situation effectively. Remember, quick action can make a significant difference in ensuring the best possible outcome.

In the case of a missed dose of Ketorolac Tromethamine Drops, it is recommended to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare professional for advice on how to safely resume your medication.

To administer Ketorolac Tromethamine Eye Drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper close to the eye without touching it; then, squeeze the prescribed number of drops into the pocket, and gently close your eye for 1-2 minutes to allow the medication to absorb.

Following are the conditions/situations when Ketorolac Tromethamine Eye Drops should not be used:

• Do not use if you have a known allergy or hypersensitivity to Ketorolac, aspirin, or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Not recommended for individuals with active peptic ulcer or a history of gastrointestinal bleeding.
• Avoid using if you have severe kidney disease or are at risk of renal impairment.
• Contraindicated in patients with severe liver impairment or active liver disease.
• Do not use if you have recently undergone heart bypass surgery (CABG).
• Not suitable for individuals with uncontrolled hypertension (high blood pressure).
• Should not be used in patients with bleeding disorders or those taking anticoagulant medications.
• Avoid using if you have a history of asthma or allergic reactions triggered by aspirin or other NSAIDs.
• Contraindicated in women who are in the third trimester of pregnancy.
• Do not use in children and adolescents under 16 years of age.

The side effects of Ketorolac Tromethamine Eye Drops may include:

• Eye burning or stinging
• Eye redness or irritation
• Blurred vision or changes in vision
• Eye itching or swelling
• Headache
• Dizziness
• Nausea
• Increased sensitivity to light

Following are the precautions and warnings for Ketorolac Tromethamine Eye Drops:

• Avoid using these drops if you have a known allergy to Ketorolac, aspirin, or other NSAIDs.
• Not recommended for long-term use; prolonged use may increase the risk of eye complications.
• If you have existing eye conditions like glaucoma or corneal ulcers, use with caution and under medical supervision.
• Patients with a history of bleeding disorders should use these drops with caution due to potential increased bleeding risk.
• Not recommended for individuals with a history of stomach ulcers or gastrointestinal bleeding.
• Discontinue use and seek medical attention if you experience severe eye pain, vision changes, or signs of an allergic reaction.
• Keep out of reach of children and pets; accidental ingestion can be harmful.

Following are the drug interactions for Ketorolac Tromethamine Drop:

• Aspirin, other NSAIDs, or corticosteroids can increase the risk of gastrointestinal bleeding and ulcers when used with Ketorolac.
• Lithium levels may be increased, potentially leading to lithium toxicity.
• Anticoagulants like warfarin or heparin may have their effects enhanced, increasing bleeding risk.
• Diuretics and angiotensin-converting enzyme (ACE) inhibitors can decrease the renal excretion of Ketorolac, potentially increasing its levels in the body.
• Probenecid can reduce the renal excretion of Ketorolac, leading to increased drug levels and potential toxicity.
• The blood pressure-lowering effects of beta-blockers and angiotensin II receptor blockers (ARBs) may be diminished by Ketorolac.
• Ketorolac may decrease the effectiveness of antihypertensive medications, including diuretics and beta-blockers.

Following are the food interactions for Ketorolac Tromethamine Drop:

• Avoid alcohol consumption during the use of these drops as it may increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of the drug, leading to increased blood levels and potential side effects.
• Caffeine-rich beverages like coffee and energy drinks may enhance the drug's effects, causing increased alertness and potential insomnia.
• High-sodium foods should be limited as Ketorolac can cause sodium retention, impacting individuals with hypertension or heart conditions.
• Foods rich in vitamin K (e.g., leafy greens, broccoli) might affect blood clotting, especially in patients on anticoagulant therapy.
• Spicy foods may exacerbate stomach irritation and increase the risk of gastrointestinal side effects.
• Dairy products may slightly reduce the absorption of Ketorolac, but this interaction is generally not considered clinically significant.
• Always consult a healthcare professional for personalized advice, especially if you have specific dietary concerns or medical conditions.

Ketorolac Tromethamine Drop should be stored with caution, ensuring it is kept in a secure location away from children's reach. Store the medication in a cool, dry place, preferably at room temperature, and protect it from exposure to direct sunlight and moisture. Maintain the integrity of the medication by keeping the bottle tightly sealed. Avoid placing it in the bathroom cabinet or near heat-emitting appliances, as temperature fluctuations can impact its effectiveness. Regularly check the expiration date, and when disposing of the drops, do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety.

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Following are the quick tips for Ketorolac Tromethamine Drops:

• Wash your hands before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and look up.
• Hold the dropper above your eye and squeeze a drop into the pocket between your lower lid and eye.
• Close your eyes gently and apply light pressure to the inner corner of your eye for 1-2 minutes.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Do not rinse the dropper; replace the cap after each use.
• Store the eye drops at room temperature, away from direct sunlight and moisture.