LANOXIN 0.25MG TAB (1S)

Digoxin 0.25mg tablets exert their therapeutic effects primarily through their interaction with the sodium-potassium ATPase pump in cardiac muscle cells. By inhibiting this pump, digoxin increases intracellular sodium levels, which subsequently leads to elevated intracellular calcium concentrations. This rise in calcium enhances cardiac contractility, making the heart muscle contract more forcefully with each heartbeat. Additionally, digoxin slows down the conduction of electrical impulses through the atrioventricular (AV) node, which can help regulate heart rate and improve the efficiency of cardiac contractions, particularly in conditions where the heart's pumping ability is compromised. The result is an overall improvement in cardiac output and a reduction in symptoms associated with heart failure.

Cardiac glycoside.

Tablet

The following are the uses of Digoxin 0.25mg Tablet:

• Used for treating heart failure, helping to improve heart function and reducing symptoms.
• Used for controlling the heart rate in conditions like atrial fibrillation, restoring a regular rhythm.
• Used for strengthening the heart's contractions to pump blood more efficiently.
• Used for managing symptoms like shortness of breath and swelling due to fluid retention.
• Used for improving exercise capacity and overall quality of life in heart failure patients.
• Used for preventing hospitalizations and reducing the progression of heart failure.
• Used for long-term management of chronic heart conditions under medical supervision.

In the case of an overdose of Digoxin 0.25mg Tablets, the primary concern is the potential for severe cardiac toxicity. Symptoms may include nausea, vomiting, irregular heartbeat, and in severe cases, cardiac arrest. Prompt medical intervention is essential, as treatment may involve administering digoxin-specific antibody fragments and managing cardiac complications. It is crucial to closely monitor vital signs and provide supportive care until the drug is eliminated from the body.

In the case of a missed dose of Digoxin 0.25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for a missed one, as this may lead to an overdose. If you miss several doses, contact your healthcare provider for advice on how to safely adjust your dosing schedule and ensure you receive the correct amount of medication.

To take Digoxin 0.25mg Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Here are the situations when Digoxin 0.25mg Tablet should not be used:

• Avoid using if you have a known allergy to Digoxin or similar medications like digitoxin.
• Do not take this medication if you have an irregular heart rhythm, such as ventricular fibrillation or ventricular tachycardia.
• Contraindicated in individuals with certain types of heart disease, such as sick sinus syndrome or AV block, without a pacemaker.
• Should not be used if you have recently had a heart attack and have certain types of heart damage.
• Avoid using Digoxin if you have untreated mineral imbalances, such as high calcium or low potassium levels in the blood.
• Not recommended for individuals with certain gastrointestinal disorders that affect digestion and absorption.
• Do not administer to infants under 12 months old due to potential increased sensitivity.
• Discontinue use if you experience visual disturbances, such as seeing yellow-green halos around lights.

The side effects of Digoxin 0.25mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Dizziness or lightheadedness
• Fatigue and weakness
• Visual disturbances, such as blurred vision or seeing halos around lights
• Confusion or disorientation
• Irregular heart rhythms (arrhythmias)

Following are the precautions and warnings for Digoxin 0.25mg Tablet:

• Patients with heart conditions like sick sinus syndrome, atrioventricular block, or ventricular fibrillation should be closely monitored as this medication can affect heart rhythm.
• Elderly patients may be more sensitive to the effects of this drug, so dosage adjustments might be necessary.
• Regular monitoring of digoxin levels in the blood is crucial to prevent toxicity, especially in patients with kidney or thyroid problems.
• Inform your doctor if you have a history of thyroid disorders, as this medication may require additional monitoring.
• Avoid taking herbal supplements like St. John's Wort concurrently, as it can affect the levels of digoxin in the body.
• Exercise caution when using this medication with diuretics or other heart medications, as it may increase the risk of side effects.
• Inform your healthcare provider if you experience any symptoms of an allergic reaction, such as rash, itching, or difficulty breathing.

Following are the drug interactions for Digoxin 0.25mg Tablet:

• Drugs that may cause digoxin toxicity include verapamil, amiodarone, and certain macrolide antibiotics like erythromycin, as they can increase digoxin levels in the body.
• Thiazide diuretics, such as hydrochlorothiazide, can raise calcium levels, which may increase the risk of digoxin-related arrhythmias.
• Combining digoxin with other drugs that affect heart rhythm, such as beta-blockers or calcium channel blockers, may require close monitoring due to potential additive effects on the heart.
• Antacids containing magnesium or aluminum can decrease the absorption of digoxin, reducing its effectiveness.
• Rifampicin, a potent enzyme inducer, can accelerate the metabolism of digoxin, leading to lower blood levels and reduced efficacy.
• Digoxin may interact with warfarin, a blood thinner, potentially altering its anticoagulant effects and requiring more frequent monitoring of blood clotting time.
• Certain medications used in chemotherapy, like cyclophosphamide, may increase the risk of digoxin toxicity, and close monitoring is necessary.

Following are the food interactions for Digoxin 0.25mg Tablet:

• Avoid consuming large amounts of green leafy vegetables like spinach, kale, and lettuce, as these are high in vitamin K, which can reduce Digoxin's effectiveness.
• Limit your intake of high-fiber foods such as bran cereals, whole grains, and legumes, as these may decrease Digoxin absorption.
• Potassium-rich foods like bananas, oranges, and tomatoes should be consumed in moderation as Digoxin can increase potassium levels.
• Avoid excessive use of salt substitutes or potassium supplements unless directed by your doctor.
• Grapefruit juice can affect Digoxin levels, so it's best to avoid or limit its consumption.
• Alcohol may increase the risk of side effects, so it's advisable to limit or avoid it during Digoxin therapy.
• Always inform your healthcare provider about your diet and any herbal supplements, as some may interact with Digoxin.
• Maintaining a balanced diet is essential for the effective management of your condition while taking Digoxin.

Digoxin 0.25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, ensuring the lid is tightly sealed to maintain their integrity. Avoid exposure to direct sunlight, moisture, or extreme temperatures, as these conditions can degrade the medication. It is crucial not to store the tablets in the bathroom or kitchen, where humidity and heat can affect their potency. Always check the expiration date on the packaging, and do not use the tablets past their expiry. When disposing of unused or expired tablets, do not flush them down the toilet or pour them into any water source. Instead, consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Digoxin 0.25mg Tablet:

• Always take the tablet as directed by your doctor; do not adjust the dosage on your own.
• Ensure you maintain a consistent schedule for taking the medication.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Take the tablet on an empty stomach, preferably 1 hour before or 2 hours after meals.
• Avoid consuming grapefruit or grapefruit juice while on this medication.
• Regularly monitor your heart rate and blood pressure as advised by your doctor.
• Store the tablets in a cool, dry place, away from direct sunlight.