Locyst 30 Tablets

L-Methylfolate is the active form of folate (vitamin B9) that is required for various biochemical processes in the body, including the synthesis of nucleic acids (DNA and RNA) and amino acids. It plays a crucial role in methylation processes, which involve the transfer of methyl groups to other molecules. L-Methylfolate acts as a cofactor for enzymes involved in the metabolism of homocysteine, converting it to methionine. By doing so, it helps maintain normal homocysteine levels, reducing the risk of cardiovascular diseases. Additionally, L-Methylfolate is essential for the proper functioning of the nervous system and for red blood cell production. It is commonly used in individuals with folate deficiency or to manage conditions related to low folate levels, such as certain types of anemia.

L-Methylfolate

Vitamin B9 (Folate) Supplement

Tablet

The following are the uses of L-Methylfolate Tablet:

• Management of folate deficiency and supplementation in individuals with inadequate folate intake.
• Treatment of certain types of anemia, especially megaloblastic anemia due to folate deficiency.
• Support in preventing neural tube defects during pregnancy by maintaining appropriate folate levels.
• Management of hyperhomocysteinemia by reducing elevated homocysteine levels, which can help reduce cardiovascular risk.
• Used in individuals with genetic variations, such as MTHFR mutations, which impair the conversion of folic acid to its active form.

Following are the doses of L-Methylfolate Tablet:

• The usual dose for adults with folate deficiency or to manage hyperhomocysteinemia is 400 mcg to 1,000 mcg daily, depending on the severity of the deficiency or the condition being treated.
• For pregnancy, especially in individuals with a history of neural tube defects, the recommended dose is 800 mcg to 1,000 mcg daily, or as advised by a healthcare provider.
• In cases of MTHFR mutations, the dose may be adjusted by the healthcare provider, typically starting at 400 mcg to 800 mcg per day.
• Dosing should be individualized based on specific medical needs and the recommendation of a healthcare provider.

In case of an overdose of L-Methylfolate Tablet, immediate medical attention should be sought. While L-Methylfolate is generally considered safe even at higher doses, excessive intake may result in unwanted effects like nausea, irritability, or sleep disturbances. If you suspect an overdose, do not take any further doses and seek guidance from a healthcare provider.

If you miss a dose of L-Methylfolate Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed dose, as this could increase the risk of side effects. Always follow the dosing instructions provided by your healthcare provider and consult them if you're unsure about how to proceed after missing a dose.

To use L-Methylfolate Tablet, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken once daily with a meal. Swallow the tablet whole with a glass of water. Do not chew, crush, or break the tablet. It's important to take the medication at the same time each day to help you remember and maintain consistent levels in your body.

Following are the situations when L-Methylfolate Tablet should not be used:

• Should not be used in individuals with a known allergy to L-Methylfolate or any of the components of the tablet.
• Contraindicated in patients with a history of hypersensitivity reactions to folic acid or other vitamin supplements.
• Caution is advised in individuals with a history of vitamin B12 deficiency, as this may indicate an underlying condition that should be addressed separately.

The side effects of L-Methylfolate Tablet may include:

• Nausea
• Headache
• Dizziness
• Stomach upset
• Bloating or gas
• Skin rash (in rare cases)

Following are the precautions and warnings for L-Methylfolate Tablet:

• Should be used with caution in individuals with a history of hypersensitivity to folic acid or any of its components.
• Caution is advised in patients with certain vitamin B12 deficiency, as the symptoms can be masked by folate supplementation.
• It is important to follow the prescribed dose, as high doses may cause side effects such as gastrointestinal discomfort.
• Consult your healthcare provider before using if you are pregnant, planning to become pregnant, or breastfeeding.
• L-Methylfolate may interact with certain medications, including anticonvulsants or methotrexate. Always inform your doctor of all medications you are taking.

Following are the drug interactions for L-Methylfolate Tablet:

• Concomitant use with certain anticonvulsants (e.g., phenytoin, carbamazepine) may reduce the effectiveness of L-Methylfolate.
• Methotrexate, when used with L-Methylfolate, can alter folate metabolism, and it is important to monitor levels and adjust doses as needed.
• High doses of folic acid can mask vitamin B12 deficiency, which may lead to neurological damage if left undiagnosed.
• L-Methylfolate may interact with some medications used in cancer treatments (e.g., fluorouracil), so it is crucial to discuss your treatment regimen with your healthcare provider.
• Certain medications that alter folate metabolism (e.g., sulfasalazine) may interfere with the absorption or action of L-Methylfolate.

Following are the food interactions for L-Methylfolate Tablet:

• There are no known significant food interactions with L-Methylfolate, but it is recommended to maintain a balanced diet that includes foods rich in folate, such as leafy greens, legumes, and fortified cereals, to support overall health.
• Excessive alcohol consumption may interfere with folate absorption and utilization, so it is advisable to limit alcohol intake while taking L-Methylfolate.
• Consuming large amounts of foods that are very high in vitamin B12, such as animal products, may obscure the effectiveness of L-Methylfolate if vitamin B12 deficiency is also present. Therefore, a balanced approach is recommended.

L-Methylfolate Tablet should be stored in a cool, dry place away from direct sunlight and moisture. It is important to keep the medication in its original container, tightly closed, to prevent contamination and degradation. Store it at room temperature, ideally between 15°C and 25°C (59°F and 77°F), and keep it out of reach of children and pets. Do not store the tablets in the bathroom, as the humidity can affect their effectiveness. If you have expired or unused tablets, dispose of them properly by following local regulations or through a medication take-back program. Never flush medications down the toilet or throw them in the trash unless instructed to do so by a healthcare provider or pharmacist.

Following are the quick tips for L-Methylfolate Tablet:

• Take L-Methylfolate as prescribed by your healthcare provider for the best results.
• Follow the dosage instructions carefully and do not take more than the recommended dose.
• It's usually best to take the tablet with or without food, as per your doctor’s instructions.
• Store the medication in a cool, dry place to maintain its effectiveness.
• If you experience any side effects or have concerns, contact your healthcare provider.
• Keep regular follow-ups with your doctor to monitor your progress.