Lyrica (75mg) 14 Capsules

Pregabalin, the active ingredient in the 75mg capsule, primarily exerts its therapeutic effects by binding to specific subunits of voltage-gated calcium channels in the central nervous system. This binding action leads to a reduction in the release of excitatory neurotransmitters, particularly glutamate, norepinephrine, and substance P. By modulating calcium channel activity, pregabalin decreases the hyperexcitability of neurons, thereby diminishing pain signaling and exerting an inhibitory effect on the transmission of pain signals in the brain and spinal cord. This mechanism of action contributes to pregabalin's effectiveness in managing neuropathic pain, seizures, and certain anxiety disorders by calming overactive nerve signals and promoting a more balanced neurotransmitter environment.

Anticonvulsant/Analgesic

Capsule

The following are the uses of Pregabalin 75mg Capsule:

• Used for managing neuropathic pain, often caused by conditions like diabetic neuropathy or shingles.
• Used for treating fibromyalgia, helping to alleviate widespread pain and improve overall quality of life.
• Used for controlling seizures in certain types of epilepsy, as an add-on therapy.
• Used for alleviating anxiety disorders, such as generalized anxiety disorder, by reducing excessive nerve activity.
• Used for managing spinal cord injuries, aiding in pain relief and reducing muscle spasms.
• Used for addressing nerve pain and discomfort following surgeries or injuries.
• Used for improving sleep disturbances associated with various conditions.
• Used for providing relief from chronic pain conditions, such as rheumatoid arthritis or migraine.

To be used as per doctor's advice

In the case of an overdose of Pregabalin 75mg Capsules, several symptoms may occur, including severe drowsiness, blurred vision, slurred speech, and impaired coordination. Individuals may also experience gastrointestinal issues like nausea, vomiting, and abdominal pain. It is important to note that an overdose can lead to more serious complications, such as respiratory depression, where breathing becomes slow and shallow. Prompt medical attention is necessary to manage these symptoms and prevent potential long-term effects.

In the case of a missed dose of Pregabalin 75mg Capsule, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time of your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to remind you to take your medication as prescribed.

To take Pregabalin 75mg Capsule, swallow the capsule whole with a full glass of water, usually 2-3 times a day, or as directed by your healthcare professional, and it can be taken with or without food, but maintaining a consistent routine is advisable.

Following are the conditions when Pregabalin 75mg Capsule should not be used:

• Must not be taken if you are allergic to Pregabalin or similar medications.
• Not suitable for individuals with a history of angioedema or severe allergic reactions.
• Should be avoided if you have uncontrolled or untreated diabetes.
• Contraindicated in patients with severe kidney disease or those on dialysis.
• Not recommended for individuals with a history of substance abuse or addiction.
• Avoid if you have a bleeding disorder or are taking blood thinners.
• Do not use if you have a heart condition such as heart failure or recent heart attack.

The side effects of Pregabalin 75mg Capsule may include:

• Dizziness and sleepiness
• Blurred vision or other visual disturbances
• Dry mouth
• Weight gain
• Swelling in hands and feet
• Difficulty in concentration
• Increased appetite
• Confusion or disorientation

Following are the precautions and warnings for Pregabalin 75mg Capsule:

• Do not start or stop the medication without consulting your doctor, as sudden discontinuation may cause withdrawal symptoms.
• This medication may cause dizziness and drowsiness, so avoid activities that require mental alertness like driving or operating machinery.
• Patients with a history of substance abuse or addiction should be closely monitored, as Pregabalin can be habit-forming.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments might be necessary.
• Pregabalin may cause vision changes and blurred vision; if affected, avoid activities that require clear vision until you know how this medication affects you.
• Inform your doctor about all your medical conditions, especially kidney or liver problems, as they may influence the dosage and effectiveness.
• Pregnant and breastfeeding women should consult their doctor before taking Pregabalin, as it may have potential risks to the fetus or infant.
• Keep this medication out of the reach of children and pets, and store it in a cool, dry place as directed.

Following are the drug interactions for Pregabalin 75mg Capsule:

• Alcohol and CNS depressants (e.g., opioids, benzodiazepines) may have additive effects on sedation and respiratory depression.
• Carbamazepine, a CYP enzyme inducer, can reduce Pregabalin levels, possibly requiring dose adjustments.
• When combined with Thioridazine, Pregabalin may increase Thioridazine levels, increasing the risk of cardiac arrhythmias.
• May increase the effects of Levothyroxine, requiring dose adjustments.
• Concomitant use with Angiotensin Converting Enzyme (ACE) inhibitors may increase the risk of angioedema.
• Pregabalin may elevate blood glucose levels, necessitating monitoring in diabetic patients.
• Can increase the sedative effects of certain antihistamines, such as Loratadine.

Following are the food interactions for Pregabalin 75mg Capsule:

• Alcohol consumption should be avoided or limited as it may increase the risk of side effects like dizziness, drowsiness, and impaired motor skills.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Pregabalin, potentially leading to increased drug levels in the body.
• High-fat meals might slightly increase the absorption of Pregabalin, but this effect is not considered clinically significant.
• Avoid caffeine or reduce intake as it may enhance the nervous system side effects of Pregabalin like anxiety, restlessness, and insomnia.
• Do not eat or drink products with high tyramine content (aged cheese, cured meats) as Pregabalin may interact, causing a spike in blood pressure.
• Consuming large amounts of chocolate or cocoa products should be avoided as they contain substances that can inhibit the breakdown of Pregabalin.
• Be cautious with herbal supplements like St. John's Wort, as it may reduce the effectiveness of Pregabalin by influencing its metabolism.
• Always consult your healthcare provider for personalized advice regarding specific food interactions.

Pregabalin 75mg capsules should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the medication in its original container, tightly sealed, to maintain its integrity and protect it from moisture and light. It is crucial not to store it in the bathroom or kitchen, as these areas can expose the capsules to heat and humidity. Always check the expiration date, and if the medication is past its prime, do not use it and dispose of it carefully. Proper disposal methods should be followed, such as returning it to a pharmacy or a drug take-back program, ensuring it is out of reach of children and pets.

No

Following are the quick tips for Pregabalin 75mg Capsule:

• Take the capsule as directed by your doctor; do not change the dosage without medical advice.
• Swallow the capsule whole with a full glass of water; do not crush, chew, or break it.
• Take the capsule at the same time each day to maintain consistent blood levels.
• If you experience mild dizziness, it may help to take the capsule with food.
• Do not stop taking the medication abruptly; consult your doctor for a proper tapering schedule.
• Avoid alcohol consumption as it may enhance side effects.
• Store the capsules in a cool, dry place, away from direct sunlight.